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Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

medrxiv.org

11–20 of 207 posts

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#11

Do they know why the shot skyrockets myocarditis risk mostly among young men? Like what's the mechanism?

"Although the mechanisms for development of myocarditis are not clear, molecular mimicry between the spike protein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and self-antigens, trigger of preexisting dysregulated immune pathways in certain individuals, immune response to mRNA, and activation of immunologic pathways, and dysregulated cytokine expression have been proposed."

https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA....

"An potential avenue for vaccine-associated myocarditis may be a nonspecific innate inflammatory immune response, or perhaps an interaction between the encoded viral spike protein of the mRNA and an as-yet undetermined cardiac protein. Studies have hypothesized that the antibodies generated in response to the mRNA spike protein may react with surface antibodies of the cardiomyocytes of susceptible hosts, provoking an inflammatory reaction and associated tissue damage."

https://www.tandfonline.com/doi/full/10.1080/14760584.2022.2...

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#12

This paper essentially argues that the risk of myocarditis in under-40 males getting 2 shots is greater (perhaps much greater) than the risk of getting it from COVID. There have been similar studies before, but none (that I saw) broken down by age and sex like this. It reads: > Despite more myocarditis events occurring in older persons, the risk following COVID-19 vaccination was largely restricted to younger males a…

Thanks for the explanation.

> argues that the risk of myocarditis in under-40 males getting 2 shots is greater (perhaps much greater) than the risk of getting it from COVID

The way I read this is the risk of myocarditis is greater with vaccination, but this does not tell me about the overall risk of serious illness/death from Covid for vaxed VS unvaxed.

So - risk of myocarditis goes up - but is it still overall safer to be vaccinated for the under 40 males, or not?

Not pushing any angle or side here - just looking for clarity (as much as possible).

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#14
An animal study found that aspiration during injection could reduce the risk of vaccine induced myocarditis. It hasn't been reproduced in humans but this seems like something worthy of further research.

https://academic.oup.com/cid/advance-article/doi/10.1093/cid...

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#15
post #14

An animal study found that aspiration during injection could reduce the risk of vaccine induced myocarditis. It hasn't been reproduced in humans but this seems like something worthy of further research. https://academic.oup.com/cid/advance-article/doi/10.1093/cid...

Can you define 'aspiration' in this case? The link is rather dense to the layperson.

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#16

Yeah but what's my risk of actually catching covid-19 vs. 100% if I just walk into my pharmacy and ask for the shot.

Over the long run your risk of catching a SARS-CoV-2 infection approaches 100%. The virus can never be eradicated and we'll all be exposed to it occasionally. Vaccination — and other measures to strengthen your immune system — can reduce the risk of serious COVID-19 symptoms to fairly low levels.

https://www.medpagetoday.com/opinion/vinay-prasad/94646

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#17
Wow, I just got the Pfizer booster a few days ago and I'm an under-40 male who has previously had pericarditis... I was worried about the risk being greater than the reward for my age group but didn't have the age-stratified data to prove it. Kind of regretting it now, especially since I only got it at the urging of my wife. I just needlessly increased the odds of a giving myself a heart issue for absolutely no reason.

Edit: somebody else pointed out that the significantly elevated risk was only observed for Moderna (mRNA-1273). Pfizer (BNT162b2) only has a slightly elevated risk after the 2nd and 3rd doses. Looks like I'll be okay after all :)

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#18
post #16

Yeah but what's my risk of actually catching covid-19 vs. 100% if I just walk into my pharmacy and ask for the shot.

Over the long run your risk of catching a SARS-CoV-2 infection approaches 100%. The virus can never be eradicated and we'll all be exposed to it occasionally. Vaccination — and other measures to strengthen your immune system — can reduce the risk of serious COVID-19 symptoms to fairly low levels. https://www.medpagetoday.com/opinion/vinay-prasad/94646

The risk of serious COVID-19 symptoms are already at quite low levels in the < 40 male group.

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#19
post #14

An animal study found that aspiration during injection could reduce the risk of vaccine induced myocarditis. It hasn't been reproduced in humans but this seems like something worthy of further research. https://academic.oup.com/cid/advance-article/doi/10.1093/cid...

Can you define 'aspiration' in this case? The link is rather dense to the layperson.

It is apparently a means to double check and make sure you are injecting into a muscle and not into a blood vessel by seeing if you can draw blood at that site before you actually inject anything.

https://askinglot.com/what-does-it-mean-to-aspirate-an-injec...

Re: Risk of myocarditis following sequential COVID-19 vaccinations by age and sex [pdf]

#20
A bit off-topic but why does PDF export sometimes produce these incredibly, seemingly gratuitously fugly font renderings? The size and spacing of the letters seems to be random. Like, here's a giant d in the middle of a word for no reason.
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