Live data from Hacker News

Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

investors.modernatx.com

191–198 of 198 posts

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#191
post #102

Earlier quoted context omitted.

Why do people keep saying this? I have literally never received a flu shot, they have always been reserved for the sick and elderly Why not, instead of shots, do these pharmaceutical companies not prioritise developing an effective at home treatment for the symptoms of Covid-19? It's very hard to see light at the end of this tunnel, which appears to be becoming a booster merry-go-round.

In my country (USA) flu vaccines are certainly not "reserved for the sick and elderly," they are emphatically recommended for almost everyone. https://www.cdc.gov/flu/prevent/flushot.htm >CDC recommends use of any licensed, age-appropriate influenza vaccine during the 2021-2022 influenza season. >Everyone 6 months of age and older should get an influenza (flu) vaccine every season with rare exception. CDC’s Advisory…

Rates of flu vaccination in the US are a little over 50%. I've never been vaccinated for it, nor my family.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#192

Earlier quoted context omitted.

Sickness from the shot is not my main concern. I'd love to see the whole risk profile for my case. I have a feeling that governments are doing "booster for everybody" for political reasons. They don't want to single out particular age group.

Can you elaborate on these "political reasons"? I've heard other people say this, too, but I can't follow the reasoning. What is the government's ulterior end result of "booster for everybody" besides increased public health? The only conspiracy I can at least follow along is the one where government is funneling money to their buddies at evil BigPharma, however there are plenty of easier ways to do this than a natio…

All the restrictions that were imposed in my country hit everybody equally. Which doesn't make sense from the risk reward perspective. For people in age group 0-30 the risk of death is close to zero. For age group 80+ is more than 15%. Orders of magnitude difference. The government tried to do a lock down for 65+, but there was a huge backlash (why they can go out but I cannot?), so the ordinance only said it's a recommendation for 65+ to stay indoors. Only thing they did is "Hours for Seniors". Only 65+ can go to shops in morning hours - 10-12 am, even though it was illegal.

There is a strong argument that boosters are pointless for young people (or even bad due to small myocarditis risk for young males), but politicians are scared of making mandatory vaccinations for 50+ only.

(Based on an interview with a well known sociologist)

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#193

Earlier quoted context omitted.

Wasn't the Moderna COVID vaccin funded by the German taxpayers?

BioNTech is a German company, so it seems more likely that the Pfizer/BioNTech vaccine was at least partially funded that way.

Oh, you're right, Moderna was funded by the US taxpayers:

https://www.forbes.com/sites/judystone/2020/12/03/the-people...

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#194

Meta: Let say I'm 30 years old, healthy, vaccinated with JJ over 6 months ago. Denmark, Sweden, Finland have banned Moderna for younger than 30. Some countries were recommending it to people over 50. Whole communication is a mess. Should I get a booster shot? What are the pros and cons? Is there any data on that? I asked a friend doctor and she said that I should get a test for antibody count (a lab one, not garbage…

The risk of getting a myocarditis from Covid19 is 4 times higher, than from the vaccine. Billions of people got mRNA vaccines in the last year. Probably hundreds of millions of people got Covid19 last year. Can you find an overall number of deaths by vaccination versus deaths by Covid19 somewhere? Germany recommends a second vaccine shot with an mRNA vaccine for everybody who JJ as their first shot. That is only 4 we…

Do you have any source? I couldn't find data that would show it by the age group.

One that I found

Norway

Total vaccinated with mRNA vaccine = 3.765.354

Total myocarditis + pericarditis = 274 (0.0073%)

One case in 13,743

Not published yet https://youtu.be/YdVymGK3OzM?t=1095

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#195
post #29

Earlier quoted context omitted.

> When asked to grade the severity of symptoms on a scale from 1 (no symptoms) to 5 (significant symptoms), 42% (33/79) reported level 3 symptoms, whereas 11% (9/79) reported level 4 symptoms. None of the cases required hospitalisation up to 13 December 2021. I am extremely optimistic.

All this talk about "mild" cases with Omicron are failing to grasp the whole situation at two very important corners: - countries affected so far have excellent immunization rates, i.e. if I take these populations as a reference, I'm just checking how immunized people are affected. Not every country has had either a lot of cases or large/successful immunization programs - if the transmission rate in South Afrika and…

It is already 2 weeks for "Omicron" hogging the news. If it is as deadly as Delta, by now you should have heard a lot of death and not "number of infected". Even if there is a delay in death due to better care, hospitals in SA should have full of patients in ICU rooms with pictures showing rows and rows of patients on ventilations. Even if you use the arguments lots of them are vaccinated, there are stil many not vaccinated especially outside of 1st world categories. SA isn't exactly at western EU level. I think this isn't as severe as most healthcare professional have expected. I would speculate this would be nature's way to confer us with some immunity.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#196
post #134

Earlier quoted context omitted.

Cons: you might be sick for a day. (Had very bad reactions to the shots and this one lasted 1 day - but I caught something else before/after...) Pros: seems to help against Omikron. And given the speed at which it spreads you don't have time to wait for updated shots or alike. JJ was particularly bad in not catching it, and even worse after 6 months. Get a booster or have a close to 100% chance to catch Omikron. Offi…

Could you cite exactly where "they announced that Moderna is way better"? All official sources I can find say that Moderna and BioNTech are "gleichwertig" (equivalent).

E.g. "Das Vakzin von BioNTech sei der Mercedes und der von Moderna der Rolls-Royce, sagte Spahn."

> https://www.tagesschau.de/inland/corona-booster-spahn-modern...

This came out the moment that the deliveries of BionTech were low. Weekly estimates are available at

> https://www.bundesgesundheitsministerium.de/fileadmin/Dateie...

The recommendations usually follow that curve. And given the current availability: good luck getting a BionTech shot.

Related: I am pretty happy how open the underlying data is. Data quality is sometimes shit (hey RKI/Gesundheitsämter, looking at you) but overall the stuff is open.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#197
post #134

Earlier quoted context omitted.

Could you cite exactly where "they announced that Moderna is way better"? All official sources I can find say that Moderna and BioNTech are "gleichwertig" (equivalent).

E.g. "Das Vakzin von BioNTech sei der Mercedes und der von Moderna der Rolls-Royce, sagte Spahn." > https://www.tagesschau.de/inland/corona-booster-spahn-modern... This came out the moment that the deliveries of BionTech were low. Weekly estimates are available at > https://www.bundesgesundheitsministerium.de/fileadmin/Dateie... The recommendations usually follow that curve. And given the current availability: good l…

Ah, and...

KW49, 2021-12-06 until 2021-12-12 had originally 3M BionTech shots available, with KW50 blocked for kids. At the same time 10M Moderna shots were available, or 20M booster shots.

2 weeks earlier, when those order volumes became clear, Spahn advertises for Moderna.

A few weeks later and we got an extra 3M BionTech shots.

Official medical sources have been clear. But StiKo & politicians an thus media communication is skewed.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#198

Earlier quoted context omitted.

Lol you get the booster. I’ve never had a flu shot and don’t intend to get one unless I’m forced to. I’ve never been accused of killing anyone or putting anyones life at risk like the case with the current virus.

I honestly don't know what this adds to the discussion though. Like....good for you? And of course you didn't get accused of such things, because it would have made zero sense in context.

Of course it makes zero sense, same with COVID vaccinations.
Post reply on HN