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Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

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Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#171
post #121

Earlier quoted context omitted.

South Africa has extremely low vaccination rates, correct? Edit: Yes, your premise seems to be quite wrong. South Africa has only 26% vaccination rate.

But South Africa has a lot of previously infected people with some degeree of natural immunization.

Sure, but so does America and the UK and so on.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#172
post #86

Earlier quoted context omitted.

And this means... ?

It means that if (big ifs!) (a) the South African peak is truly a peak and (b) vaccine-acquired immunity staves off severe illness to the same extent that infection-acquired immunity does[*], Europe is not in for “quite a ride.” As in South Africa, cases will briefly peak at a very high level, but without a corresponding high level of hospitalizations or deaths. [*] while only ~30% of SA’s population has been vaccina…

The likely higher transmissibility in combination with a generally more elderly population and vaccination gaps among older individuals in some European countries (e.g. Germany) could still spell trouble.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#173

Earlier quoted context omitted.

Thank you. I'm not aware of the complications of developing an anti-viral for this disease (and I'm not going to go into the debate around existing anti-virals). I did not intend to be dismissive of the effort involved. I'm coming at it from a place of real frustration. I can't see how this pandemic ends without an effective treatment.

It may not end. We missed the 'golden window' early on in the epidemic when (for instance like SARS-CoV) it could have been contained. But now we have a real problem. The big difference between SARS-CoV and COVID-19 is that the former first gives you symptoms and then makes you contagious and with COVID-19 it is the other way around. That simple fact alone possible made it impossible to contain this. But we never rea…

Yeah, I had a real hard time with this at the beginning, knowing how people behave.

Trying to be as apolitical as possible here, but the leadership flopped hard and wrong here, and…well…welcome to the endemic reality.

As an aside: the World of Warcraft model was more accurate than most would have expected.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#174

If my net worth is 1 cent, and I pick up 37 cents on the street, I’ve increased my net worth over 37-fold. But I’m still worth only 38 cents. Maybe I can buy a gumball. Maybe. 37-fold is meaningless. Unfortunately this press release doesn’t have anything more useful either.

It's the only solid metric they can report on quantitatively. What else could they report on? There's no way to measure T/B-cell immunity.

Plus you can understand that if 2 shots give a low immunity level of like 30%, the increase is substantial which would put 3 shots easily above 50% which is solid.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#175

Meta: Let say I'm 30 years old, healthy, vaccinated with JJ over 6 months ago. Denmark, Sweden, Finland have banned Moderna for younger than 30. Some countries were recommending it to people over 50. Whole communication is a mess. Should I get a booster shot? What are the pros and cons? Is there any data on that? I asked a friend doctor and she said that I should get a test for antibody count (a lab one, not garbage…

The risk of getting a myocarditis from Covid19 is 4 times higher, than from the vaccine. Billions of people got mRNA vaccines in the last year. Probably hundreds of millions of people got Covid19 last year. Can you find an overall number of deaths by vaccination versus deaths by Covid19 somewhere? Germany recommends a second vaccine shot with an mRNA vaccine for everybody who JJ as their first shot. That is only 4 we…

Generally yes, but for young men, it looks like the risks of getting myocarditis is higher from the Moderna vaccine than from covid. It is not the case for Pfizer/BioNTech.

In every case, the benefits still seem to outweigh the risks but it is recommended that young men get the Pfizer/BioNTech shot over Moderna.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#176
post #105

Earlier quoted context omitted.

Us sheep will put up with this one, if it’s the last one. Just this one last booster. Now if we tread into the 4th or 5th booster for the n-th variant, then that’s my breaking point and I will have to call out the shenanigans. Moderna’s revenue since 2016: https://www.statista.com/statistics/1107794/revenue-and-net-... These companies certainly don’t mind the state of things.

Good luck. I already reached my breaking point with omicron. I am not taking a booster at all. It is quite clear that this will never end. We have to send a message to the authorities.

The point is they gotta get boosters in people before the hospitals get overcrowded (only then people will realize they should've gotten a booster or the shots). People can't figure this out, so they need to use the media to get the message out.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#177

Earlier quoted context omitted.

Cons: you might be sick for a day. (Had very bad reactions to the shots and this one lasted 1 day - but I caught something else before/after...) Pros: seems to help against Omikron. And given the speed at which it spreads you don't have time to wait for updated shots or alike. JJ was particularly bad in not catching it, and even worse after 6 months. Get a booster or have a close to 100% chance to catch Omikron. Offi…

The lack of transparency since day one of the pandemic is, in my opinion, the main reason for so many people to be against all measures, including vaccination mandates. From making assertions about the virus before the science was out (science rarely ever speaks in certainty), to straight out lies. From science, to pharma, to state medical officers, to government, to media, we're stuck in a terrible game of phone.

What did they lie about? lol. Cherry-picking everything

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#178

Earlier quoted context omitted.

800 million in revenue seems really reasonable for having developed one of the best, it not the best, COVID 19 vaccines in the world. Consider that Apple's annual revenue from just airpods is over 10 billion.

Wasn't the Moderna COVID vaccin funded by the German taxpayers?

BioNTech is a German company, so it seems more likely that the Pfizer/BioNTech vaccine was at least partially funded that way.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#179

Earlier quoted context omitted.

You’re thinking about the booster wrong. Having a vaccine for the ancestral strain is actually pretty great, because it confers (or has to this point) some level of protection against all child strains due to there being at least enough similarity still. If you make some highly specific omicron booster, it might not do anything against whatever variant comes next. As long as the original shot keeps working, it’s the…

With how much more contagious omicron is, I wonder what the odds are that future strains will come from it or an earlier strain? In particular, I assume there is some zero-sum competition going on between strains—if someone gets infected with Omicron it becomes very unlikely that they would later contract Delta—thus at a certain point Omicron is everywhere and less contagious strains largely die out? This has happene…

It’s sort of interesting to think about. One epidemiologist I follow mused that we could end up with delta and omicron co-existing, with omicron hitting the vaccinated (but not boosted) while delta continues to wreak havoc among the unvaccinated. It’s hard to tell if omicron is actually more contagious than delta, or if it just appears to be because of its immunity evasion.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#180
post #170
post #160

Earlier quoted context omitted.

>But what if 50% of people could avoid covid if they fixed their zinc deficiency? That's a truly absurd exaggeration. We're talking about a marginal effect on at best a marginal proportion of the population. >So why are they not letting people get tested for nutritional deficiencies? "they' (whoever "they" may be) are preventing people from getting tested for mineral deficiencies? Really? How are 'they' doing this? I…

>We're talking about a marginal effect on at best a marginal proportion of the population. You have no evidence for this statement because it is not being tested. When they test patients with severe covid they find a high level of zinc deficiency. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482607/ "The study data clearly show that a significant number of COVID-19 patients were zinc deficient. These zinc deficient…

It's bee extensively, directly tested by randomised controlled trials using vitamin supplements and no effect was found:

https://www.health.harvard.edu/blog/do-vitamin-d-zinc-and-ot...

"The researchers found that people receiving the supplements, whether individually or combined, had no improvement in symptoms or a faster recovery when compared with otherwise similar patients receiving neither supplement."

Also it's just an absurd fantasy to say that 'they' are stopping people taking supplements or being tested.

"Despite questions about the overall benefit of these supplements, many doctors began prescribing them routinely in the early days of the COVID-19 pandemic..."

So some doctors have been doing this and all the options have been explored, and the kind of evidence you'd need to push this at the population level just isn't there. Look, the information is out there, these supplements are available, you can get tested for deficiencies any time you like, go for it. There is no conspiracy, it's just that overall many medical professionals feel that this has been studies and they just don't agree with you that this is a significant factor, that's all.

Why do you think they disagree, if not a genuine difference of opinion? What's the alternative narrative? The entire medical profession across many disciplines and diverse political opinions and different nationalities is united against humanity?

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