Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

investors.modernatx.com

Post reply on HN
Print view View original

141–150 of 198 posts

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#141

Post by ed_balls »

kypro wrote: post #109
ed_balls wrote: post #87

Earlier quoted context omitted.

I really hard to compare UK and SA. - average age 28 SA vs 40 UK - a lot of immunocompromised people in SA (AIDS) - UK has most of it immunity from vaccination which was mainly targeting AC2 receptor. It's possible that natural immunity or Sinovac (attenuated virus) has better protection than mRNA vaccines - not confirmed. - SA is doing fewer tests.

> average age 28 SA vs 40 UK I think this is definitely part of the explanation. > A lot of immunocompromised people in SA (AIDS) Wouldn't this mean more deaths or am I missing something? Are COVID deaths in AIDS patients attributed to AIDS not COVID? > UK has most of it immunity from vaccination which was mainly targeting AC2 receptor. It's possible that natural immunity or Sinovac (attenuated virus) has better prot…

> Wouldn't this mean more deaths or am I missing something? Are COVID deaths in AIDS patients attributed to AIDS not COVID?

That's the thing, it's really hard to compare. There is no standardisation. You can have a person dying from AIDS counted as a COVID death. The other extreme is that someone with AIDS, in theory, could have a COVID infection for decades and be tested n times.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#142

Post by codr7 »

jokowueu wrote: post #91
podgaj wrote: post #58

Earlier quoted context omitted.

I have never heard of a population wide mandate for a flu vaccine however. And since 2004 the average effectiveness for the flu vaccine is about 40% so I guess if you are in a high risk group it might increase your survival a bit, but not enough effectiveness for a national mandate. The death rate of the flu is about 0.01% for all populations. I mean, would you get a surgery that had a 40% success rate if your chance…

That's a false equivalence . A jab isn't as evasive as surgery, it doesn't carry the same risks,costs,time etc

How can you be so sure?

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#143

Post by astura »

nradov wrote: post #128
dahfizz wrote: post #82

Earlier quoted context omitted.

By letting people die. If covid came around in the 1200s, then everyone would have gotten it and ~3% of the world population would have died. Definitely suboptimal but nowhere near an extinction event.

The infection fatality rate was never as high as 3%. The CDC estimated it at 0.6% back when almost no one was vaccinated.

Nobody said it was?

The question was about a world without modern medicine. It's totally reasonable to speculate there would be a higher fatality rate without medical intervention keeping people from dying.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#144

Post by throwawayfear »

massysett wrote: post #115

If my net worth is 1 cent, and I pick up 37 cents on the street, I’ve increased my net worth over 37-fold. But I’m still worth only 38 cents. Maybe I can buy a gumball. Maybe. 37-fold is meaningless. Unfortunately this press release doesn’t have anything more useful either.

No post body was provided.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#145

Post by cracell »

massysett wrote: post #115

If my net worth is 1 cent, and I pick up 37 cents on the street, I’ve increased my net worth over 37-fold. But I’m still worth only 38 cents. Maybe I can buy a gumball. Maybe. 37-fold is meaningless. Unfortunately this press release doesn’t have anything more useful either.

"Salesman says product he's selling is great!"

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#146

Post by astura »

ed_balls wrote: post #99

Meta: Let say I'm 30 years old, healthy, vaccinated with JJ over 6 months ago. Denmark, Sweden, Finland have banned Moderna for younger than 30. Some countries were recommending it to people over 50. Whole communication is a mess. Should I get a booster shot? What are the pros and cons? Is there any data on that? I asked a friend doctor and she said that I should get a test for antibody count (a lab one, not garbage…

FWIW your reaction to previous vaccines/doses doesn't predict your reaction to future vaccines/doses.

Up until my second COVID vaccine I had never had any reaction to any vaccine other than a bit of pain in the injection site. My first COVID shot caused zero symptoms. So I was surprised when my second shot caused a day of flu-like symptoms. My booster, however, caused no symptoms other than swollen lymph nodes in one armpit.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#147

Post by peteradio »

skuhn wrote: post #51
NomeChomsky wrote: post #36

Quoted post unavailable.

Your claim is directly contradicted by the abstract of the paper you linked to: "We estimated an extra two (95% confidence interval (CI) 0, 3), one (95% CI 0, 2) and six (95% CI 2, 8) myocarditis events per 1 million people vaccinated with ChAdOx1, BNT162b2 and mRNA-1273, respectively, in the 28 days following a first dose and an extra ten (95% CI 7, 11) myocarditis events per 1 million vaccinated in the 28 days afte…

He's referring to the under 40 group which is indeed supported by the paper to say there's double the number of myocarditus events per pop group among those who were double moderna vacc vs sars-cov2 infected.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#148

Post by podgaj »

simonh wrote: post #98
podgaj wrote: post #32

Earlier quoted context omitted.

I want to know why they never fully investigate why there is such a disparity of outcomes between people who catch SARS2. One can say obesity, but what does that mean physiologically? Is it just they already how too much inflammation? https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.119.... Of is it that they are deficiency in some nutrient that causes the inflammation? https://www.sciencedirect.com/science/ar…

>I want to know why they never fully investigate why there is such a disparity of outcomes between people who catch SARS2. It's been, and is being very intensively investigated. We know an awful lot about some aspects of it, but the factors that lead to different immune system responses are very difficult to figure out despite many decades of research into the mechanisms. In the first instance, the specific sites and…

> the factors that lead to different immune system responses are very difficult to figure out despite many decades of research into the mechanisms.

I totally disagree with this. It is not difficult, they are ignoring it.

Zinc deficiency is a well known risk for immunological dysfunction, yet where is all the zinc testing and research during this pandemic?

https://www.nature.com/articles/1601479

https://www.annualreviews.org/doi/abs/10.1146/annurev.nutr.2...

And Why is all this not front page news?

https://www.sciencedirect.com/science/article/pii/S221454002...

https://sljch.sljol.info/articles/abstract/10.4038/sljch.v50...

https://wjpr.s3.ap-south-1.amazonaws.com/article_issue/800cc...

https://www.cambridge.org/core/journals/british-journal-of-n...

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#149

Post by Arnt »

zibzab wrote: post #17
Arnt wrote: post #11

Earlier quoted context omitted.

This concerns omicron, and omicron is a quick worker. The British measured its doubling time to 1.5 days in London, which means that it goes from one infectee to a million in just a month. What happens later is not really significant.

No, I meant how does the booster effect reduces over time. The effectiveness of the first two over time went down much quicker than initially anticipated. The question is if the 3rd shot is somehow different.

I see. It has to be an improvement AIUI, but how large is an open question still.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#150

Post by simonh »

podgaj wrote: post #148
simonh wrote: post #98

Earlier quoted context omitted.

>I want to know why they never fully investigate why there is such a disparity of outcomes between people who catch SARS2. It's been, and is being very intensively investigated. We know an awful lot about some aspects of it, but the factors that lead to different immune system responses are very difficult to figure out despite many decades of research into the mechanisms. In the first instance, the specific sites and…

> the factors that lead to different immune system responses are very difficult to figure out despite many decades of research into the mechanisms. I totally disagree with this. It is not difficult, they are ignoring it. Zinc deficiency is a well known risk for immunological dysfunction, yet where is all the zinc testing and research during this pandemic? https://www.nature.com/articles/1601479 https://www.annualrevi…

The correlation, if it exists, is marginal and there's even some reason to suspect there's a slight negative correlation.

https://www.frontiersin.org/articles/10.3389/fimmu.2021.6993...

I have an aunt who's adamantly ant-vax. She goes on and on about how we should all be 'boosting our immune systems' to naturally protect us against the virus. The fact is there's no such thing as boosting a naturally healthy immune system. You can mitigate deficiencies to strengthen a compromised immune system, yes, but load up excessively on supplements and such and you can quickly end up suffering from toxicities to no measurable advantage. Nutrition is best left to being managed by doctors and nutritionists using the established health service mechanisms for that discipline (well, here in the UK anyway).

Nutrition may well play an important role for individuals based on their specific needs, but it's just not at all appropriate to push it as a mitigation at a population level. For the vast majority of people it's either a complete distraction or could even do more harm than good. People need specific guidance based on their health circumstances - if there even are any significant benefits at all which isn't even entirely clear.

Post reply on HN