Live data from Hacker News

Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

investors.modernatx.com

111–120 of 198 posts

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#111

Meta: Let say I'm 30 years old, healthy, vaccinated with JJ over 6 months ago. Denmark, Sweden, Finland have banned Moderna for younger than 30. Some countries were recommending it to people over 50. Whole communication is a mess. Should I get a booster shot? What are the pros and cons? Is there any data on that? I asked a friend doctor and she said that I should get a test for antibody count (a lab one, not garbage…

Another pro you might not hear about much is sleep. I slept like a baby the night I had each shot.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#112

Earlier quoted context omitted.

>>Why do people keep saying this? Because the population on HN is not homogeneus and different regions in the world approach the flu vaccine differently? In some countries it's completely free and it's normal to get it every year, and even in some countries where it isn't, there's only a nominal cost and usually the employer covers it - so most people get the flu shot too. Not a big deal at all. >> they have always b…

>>Or would you rather that they stopped the development of vaccines completely and focused just on the treatment of symptoms? No, but surely it would be easier to produce an antiviral for home use that would alleviate the symptoms of Covid-19, rather than relying on the development of a vaccine, and then demanding almost universal uptake for it to work? Then we could have had vaccines for the sick, elderly, immunocom…

That's the equivalent of 'a mere matter of engineering'. Developing anti-viral drugs is hard, for plenty of viruses we have vaccines but no anti-virals, for RNA based viruses (which mutate rapidely) anti-virals are even harder.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#113
post #29

Earlier quoted context omitted.

> When asked to grade the severity of symptoms on a scale from 1 (no symptoms) to 5 (significant symptoms), 42% (33/79) reported level 3 symptoms, whereas 11% (9/79) reported level 4 symptoms. None of the cases required hospitalisation up to 13 December 2021. I am extremely optimistic.

All this talk about "mild" cases with Omicron are failing to grasp the whole situation at two very important corners: - countries affected so far have excellent immunization rates, i.e. if I take these populations as a reference, I'm just checking how immunized people are affected. Not every country has had either a lot of cases or large/successful immunization programs - if the transmission rate in South Afrika and…

Yeah, Omicron is is still potentially a huge threat to countries which both have low vaccine uptake amongst the most at risk and avoided people being infected by previous variants. I think that might only apply to Germany, Austria and China at this point though - almost everywhere on the planet had widespread infection in past waves, and the exceptions generally have high vaccination rates by now.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#114

Earlier quoted context omitted.

You don’t lose your job for not getting the flu vaccine. Again, it’s an unprecedented situation and I’ll accept the mandate for the three shots, but this has to have an end at some point.

Quoted post unavailable.

Except of course that it isn't. If you look closely at the available data you'll see that since the start of the vaccination campaigns the ratio of people dying/being hospitalized versus the number of people infected has steadily improved. Without the vaccines it would be a completely different ballgame.

There is plenty wrong with big pharma, but right now they are doing a reasonably good job at helping us all.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#115
If my net worth is 1 cent, and I pick up 37 cents on the street, I’ve increased my net worth over 37-fold.

But I’m still worth only 38 cents. Maybe I can buy a gumball. Maybe.

37-fold is meaningless. Unfortunately this press release doesn’t have anything more useful either.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#116
post #105

Earlier quoted context omitted.

Us sheep will put up with this one, if it’s the last one. Just this one last booster. Now if we tread into the 4th or 5th booster for the n-th variant, then that’s my breaking point and I will have to call out the shenanigans. Moderna’s revenue since 2016: https://www.statista.com/statistics/1107794/revenue-and-net-... These companies certainly don’t mind the state of things.

Good luck. I already reached my breaking point with omicron. I am not taking a booster at all. It is quite clear that this will never end. We have to send a message to the authorities.

What is the exact message? I agree this is frustrating but I don’t understand what message not getting a booster will send.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#117

Quoted post unavailable.

A double shot of moderna more than halved myocarditis vs getting covid according to your link? >> We estimated an extra … six (95% CI 2, 8) myocarditis events per 1 million people vaccinated with … mRNA-1273 … in the 28 days following a first dose and an extra ten (95% CI 7, 11) myocarditis events per 1 million vaccinated in the 28 days after a second dose of mRNA-1273 >> This compares with an extra 40 (95% CI 38, 41…

That's the average, but if you look at the under 40 cohort, the risk is doubled (Figure 2). The Myocarditis cases from vaccination overwhelmingly affect males in the younger age groups.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#118

Meta: Let say I'm 30 years old, healthy, vaccinated with JJ over 6 months ago. Denmark, Sweden, Finland have banned Moderna for younger than 30. Some countries were recommending it to people over 50. Whole communication is a mess. Should I get a booster shot? What are the pros and cons? Is there any data on that? I asked a friend doctor and she said that I should get a test for antibody count (a lab one, not garbage…

I'd get it -- J&J is already known to be weaker coverage, and Omicron spreads so easily that the odds you get COVID are fairly high if you interact with people regularly. If you're looking at it from a sickness perspective, the expected value of sickness without the shot is probably higher (lower chance of many days of feeling bad vs high chance of a single day). Single person anecdote: I was quite sick from J&J and…

Same for me. I had J&J and now moderna booster. Other than mild body pain and tiredness, booster was pretty smooth. Maybe because it's a half dosage

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#119
post #93

Earlier quoted context omitted.

OPs comment is deleted, so I can't see the paper. Is there a reason to believe the risk of myocarditis will continue to rise with each booster?

The comment is flagged by the "community", not deleted. You can see it by turning on "showdead" in the settings.

Cool, thanks!

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#120

Meta: Let say I'm 30 years old, healthy, vaccinated with JJ over 6 months ago. Denmark, Sweden, Finland have banned Moderna for younger than 30. Some countries were recommending it to people over 50. Whole communication is a mess. Should I get a booster shot? What are the pros and cons? Is there any data on that? I asked a friend doctor and she said that I should get a test for antibody count (a lab one, not garbage…

Cons: you might be sick for a day. (Had very bad reactions to the shots and this one lasted 1 day - but I caught something else before/after...) Pros: seems to help against Omikron. And given the speed at which it spreads you don't have time to wait for updated shots or alike. JJ was particularly bad in not catching it, and even worse after 6 months. Get a booster or have a close to 100% chance to catch Omikron. Offi…

The lack of transparency since day one of the pandemic is, in my opinion, the main reason for so many people to be against all measures, including vaccination mandates. From making assertions about the virus before the science was out (science rarely ever speaks in certainty), to straight out lies. From science, to pharma, to state medical officers, to government, to media, we're stuck in a terrible game of phone.
Post reply on HN