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Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

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Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#21

Post by mattrighetti »

zibzab wrote: post #17
Arnt wrote: post #11

Earlier quoted context omitted.

This concerns omicron, and omicron is a quick worker. The British measured its doubling time to 1.5 days in London, which means that it goes from one infectee to a million in just a month. What happens later is not really significant.

No, I meant how does the booster effect reduces over time. The effectiveness of the first two over time went down much quicker than initially anticipated. The question is if the 3rd shot is somehow different.

Nobody knows for now since I haven't read any official study/data on that.

One thing for sure is that it is likely to follow the path of the previous two shots: antibodies are going to fade with time but you will still be protected against severe illness.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#22

Post by amznbyebyebye »

beervirus wrote: post #13
crate_barre wrote: post #10

Earlier quoted context omitted.

Us sheep will put up with this one, if it’s the last one. Just this one last booster. Now if we tread into the 4th or 5th booster for the n-th variant, then that’s my breaking point and I will have to call out the shenanigans. Moderna’s revenue since 2016: https://www.statista.com/statistics/1107794/revenue-and-net-... These companies certainly don’t mind the state of things.

Why? We get a flu booster every year, and that’s fine. I’m happy to get a shot every so often if it means I can go about my life like normal.

Lol you get the booster. I’ve never had a flu shot and don’t intend to get one unless I’m forced to. I’ve never been accused of killing anyone or putting anyones life at risk like the case with the current virus.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#23

Post by throwawayxmas »

crate_barre wrote: post #15
beervirus wrote: post #13

Earlier quoted context omitted.

Why? We get a flu booster every year, and that’s fine. I’m happy to get a shot every so often if it means I can go about my life like normal.

You don’t lose your job for not getting the flu vaccine. Again, it’s an unprecedented situation and I’ll accept the mandate for the three shots, but this has to have an end at some point.

Of course it ends, when the hospitals aren't a mess? Until then, we have to keep getting vaccines. It's clear that the wave after wave it's getting easier in the hospitals.

Remember, that hospital systems in pretty much all countries has collapsed. They have to move surgeries and some patients are even afraid to go to hospitals at this point.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#24

Post by zrail »

crate_barre wrote: post #15
beervirus wrote: post #13

Earlier quoted context omitted.

Why? We get a flu booster every year, and that’s fine. I’m happy to get a shot every so often if it means I can go about my life like normal.

You don’t lose your job for not getting the flu vaccine. Again, it’s an unprecedented situation and I’ll accept the mandate for the three shots, but this has to have an end at some point.

This isn't something that can be willed away. Your acceptance means nothing to a virus.

What's likely to happen is a covid vax will get rolled in with the quadrivalent annual flu vax so most people will just get one annual booster.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#25

Post by DrAwdeOccarim »

crate_barre wrote: post #15
beervirus wrote: post #13

Earlier quoted context omitted.

Why? We get a flu booster every year, and that’s fine. I’m happy to get a shot every so often if it means I can go about my life like normal.

You don’t lose your job for not getting the flu vaccine. Again, it’s an unprecedented situation and I’ll accept the mandate for the three shots, but this has to have an end at some point.

Maybe at your place of employment you won't get fired for not keeping your vaccinations up to spec, but there are many employees that have had vaccine mandates for decades...nearly every hospital, most research laboratories (especially ones that handle human biological specimens), nearly every school...

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#26

Post by CrazyCatDog »

crate_barre wrote: post #15
beervirus wrote: post #13

Earlier quoted context omitted.

Why? We get a flu booster every year, and that’s fine. I’m happy to get a shot every so often if it means I can go about my life like normal.

You don’t lose your job for not getting the flu vaccine. Again, it’s an unprecedented situation and I’ll accept the mandate for the three shots, but this has to have an end at some point.

Clinics routinely require staff and physicians to be vaccinated against the flu lest there be an exemption on file.

Granted this article shared that the rate is low, it also surfaced mandates for healthcare:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020194/

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#27

Post by zrail »

pixiemaster wrote: post #16
beervirus wrote: post #12

Earlier quoted context omitted.

> When asked to grade the severity of symptoms on a scale from 1 (no symptoms) to 5 (significant symptoms), 42% (33/79) reported level 3 symptoms, whereas 11% (9/79) reported level 4 symptoms. None of the cases required hospitalisation up to 13 December 2021. I am extremely optimistic.

in terms of covid hospitalisations overwhelming our hospitals: i‘m optimistic as well that this might not happen at scale. but in terms of a large part of society getting sick (level 3 still makes you stick in bed) at the same time - this will lead to worker shortage - i’m kind of neutral-pessimistic. in terms of longterm long covid effect on our demographic - i’m fearful. in terms of society getting their act togeth…

> in terms of covid hospitalisations overwhelming our hospitals: i‘m optimistic as well that this might not happen at scale.

I see no reason for this optimism. Every hospital that I know of in SE Michigan has been over capacity for several weeks. We have gotten regular emails from both hospital systems in Ann Arbor begging everyone to get vaccinated.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#28

Post by mjfl »

beervirus wrote: post #13
crate_barre wrote: post #10

Earlier quoted context omitted.

Us sheep will put up with this one, if it’s the last one. Just this one last booster. Now if we tread into the 4th or 5th booster for the n-th variant, then that’s my breaking point and I will have to call out the shenanigans. Moderna’s revenue since 2016: https://www.statista.com/statistics/1107794/revenue-and-net-... These companies certainly don’t mind the state of things.

Why? We get a flu booster every year, and that’s fine. I’m happy to get a shot every so often if it means I can go about my life like normal.

I don't get a severe fever from flu shots.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#29

Post by bipson »

beervirus wrote: post #12
greatpatton wrote: post #9

Seems from this case in Norway ( https://www.eurosurveillance.org/content/10.2807/1560-7917.E... ) that Moderna is a tad bit better at preventing infection from Omicron, but when you see the overall number of cases among fully vaccinated people I'm not very optimistic that vaccine with do something at limiting the spread of infection, however I'm optimistic that they will still be efficient to prevent severe disease.

> When asked to grade the severity of symptoms on a scale from 1 (no symptoms) to 5 (significant symptoms), 42% (33/79) reported level 3 symptoms, whereas 11% (9/79) reported level 4 symptoms. None of the cases required hospitalisation up to 13 December 2021. I am extremely optimistic.

All this talk about "mild" cases with Omicron are failing to grasp the whole situation at two very important corners:

- countries affected so far have excellent immunization rates, i.e. if I take these populations as a reference, I'm just checking how immunized people are affected. Not every country has had either a lot of cases or large/successful immunization programs

- if the transmission rate in South Afrika and GB is any indication (reminder, both have quite good immunization rates), there will still be enough severe cases, because there will be just an unbelievable amount of overall cases in a very short timeframe and even with Omicron and a well immunized population, some remaining x% will land in the hospital.

I would argue that at the rate Omicron currently growing in GB, NL, DK, NO, etc. this thing will go on a rampage all over Europe. The amount of spread virus is so much not comparable to Delta getting to populations that were so far better protected, i.e. child care, elderly care, etc.

Countries like Germany and Austria are seriously in for a ride. Yes, I'm quite pessimistic here and I really hope I am wrong.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#30

Post by forgotmyoldname »

beervirus wrote: post #13
crate_barre wrote: post #10

Earlier quoted context omitted.

Us sheep will put up with this one, if it’s the last one. Just this one last booster. Now if we tread into the 4th or 5th booster for the n-th variant, then that’s my breaking point and I will have to call out the shenanigans. Moderna’s revenue since 2016: https://www.statista.com/statistics/1107794/revenue-and-net-... These companies certainly don’t mind the state of things.

Why? We get a flu booster every year, and that’s fine. I’m happy to get a shot every so often if it means I can go about my life like normal.

Flu shots are “updated” every year for new variants.

I might be wrong, but I think covid boosters so far are all just extra doses of the same old material. I don’t think anyone would get flu shots if we were expected to get 4 doses of the same thing with demonstrated lower efficacy.

I’m perfectly fine with getting boosters if they’re adjusted to be more effective against new strains. Getting a third, fourth, or fifth dose of the same old strain that’s basically been evolutionarily eliminated seems off to me.

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