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Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

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11–20 of 198 posts

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#11
post #7

But how does this reduce over time?

This concerns omicron, and omicron is a quick worker. The British measured its doubling time to 1.5 days in London, which means that it goes from one infectee to a million in just a month. What happens later is not really significant.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#12

Seems from this case in Norway ( https://www.eurosurveillance.org/content/10.2807/1560-7917.E... ) that Moderna is a tad bit better at preventing infection from Omicron, but when you see the overall number of cases among fully vaccinated people I'm not very optimistic that vaccine with do something at limiting the spread of infection, however I'm optimistic that they will still be efficient to prevent severe disease.

> When asked to grade the severity of symptoms on a scale from 1 (no symptoms) to 5 (significant symptoms), 42% (33/79) reported level 3 symptoms, whereas 11% (9/79) reported level 4 symptoms. None of the cases required hospitalisation up to 13 December 2021.

I am extremely optimistic.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#13

Earlier quoted context omitted.

Shame you’re being downvoted and people don’t get that there might be just a small conflict of interest for the Pfizer ceo to be the one dictating that we need a fourth vaccine. [1] [1] https://www.google.com/amp/s/www.cnbc.com/amp/2021/12/08/omi...

Us sheep will put up with this one, if it’s the last one. Just this one last booster. Now if we tread into the 4th or 5th booster for the n-th variant, then that’s my breaking point and I will have to call out the shenanigans. Moderna’s revenue since 2016: https://www.statista.com/statistics/1107794/revenue-and-net-... These companies certainly don’t mind the state of things.

Why? We get a flu booster every year, and that’s fine. I’m happy to get a shot every so often if it means I can go about my life like normal.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#14
post #4

sounds like vaccine marketing is crossing into the "25% more nuts and 8g protein per serving" territory. I suppose that regular consumer isnt ready to evaluate all the aspects of the difference between say 20-fold and 37-fold antibody levels beside the "bigger is better" (is it? does high antibody levels come for free? i remember a study where methotrexate treatment to kill B-cells which were of high levels after flu…

I’ve been on the other side of these types of press releases and you’re exactly right. Always report the most “impressive” numbers even if you know they don’t actually translate to a difference in outcome (usually because you don’t have that data yet).

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#15

Earlier quoted context omitted.

Us sheep will put up with this one, if it’s the last one. Just this one last booster. Now if we tread into the 4th or 5th booster for the n-th variant, then that’s my breaking point and I will have to call out the shenanigans. Moderna’s revenue since 2016: https://www.statista.com/statistics/1107794/revenue-and-net-... These companies certainly don’t mind the state of things.

Why? We get a flu booster every year, and that’s fine. I’m happy to get a shot every so often if it means I can go about my life like normal.

You don’t lose your job for not getting the flu vaccine. Again, it’s an unprecedented situation and I’ll accept the mandate for the three shots, but this has to have an end at some point.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#16

Seems from this case in Norway ( https://www.eurosurveillance.org/content/10.2807/1560-7917.E... ) that Moderna is a tad bit better at preventing infection from Omicron, but when you see the overall number of cases among fully vaccinated people I'm not very optimistic that vaccine with do something at limiting the spread of infection, however I'm optimistic that they will still be efficient to prevent severe disease.

> When asked to grade the severity of symptoms on a scale from 1 (no symptoms) to 5 (significant symptoms), 42% (33/79) reported level 3 symptoms, whereas 11% (9/79) reported level 4 symptoms. None of the cases required hospitalisation up to 13 December 2021. I am extremely optimistic.

in terms of covid hospitalisations overwhelming our hospitals: i‘m optimistic as well that this might not happen at scale.

but in terms of a large part of society getting sick (level 3 still makes you stick in bed) at the same time - this will lead to worker shortage - i’m kind of neutral-pessimistic.

in terms of longterm long covid effect on our demographic - i’m fearful.

in terms of society getting their act together to avert anything of this: absolutely pessimistic.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#17
post #11
post #7

But how does this reduce over time?

This concerns omicron, and omicron is a quick worker. The British measured its doubling time to 1.5 days in London, which means that it goes from one infectee to a million in just a month. What happens later is not really significant.

No, I meant how does the booster effect reduces over time.

The effectiveness of the first two over time went down much quicker than initially anticipated. The question is if the 3rd shot is somehow different.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#18

Earlier quoted context omitted.

Shame you’re being downvoted and people don’t get that there might be just a small conflict of interest for the Pfizer ceo to be the one dictating that we need a fourth vaccine. [1] [1] https://www.google.com/amp/s/www.cnbc.com/amp/2021/12/08/omi...

Us sheep will put up with this one, if it’s the last one. Just this one last booster. Now if we tread into the 4th or 5th booster for the n-th variant, then that’s my breaking point and I will have to call out the shenanigans. Moderna’s revenue since 2016: https://www.statista.com/statistics/1107794/revenue-and-net-... These companies certainly don’t mind the state of things.

As an investor in Pfizer I really love it when there are new variants and we all need more vaccines. It’s more money for me. As a human being, I worry about the (currently unknown) long term effects on my health.

Re: Moderna booster increased neutralizing antibody levels against Omicron ~37-fold

#19

Earlier quoted context omitted.

Why? We get a flu booster every year, and that’s fine. I’m happy to get a shot every so often if it means I can go about my life like normal.

You don’t lose your job for not getting the flu vaccine. Again, it’s an unprecedented situation and I’ll accept the mandate for the three shots, but this has to have an end at some point.

Why is it three? Why can’t they make it effective with one vaccine? Hmm maybe because three vaccines is 3x the revenue they get vs. from one vaccine. They’re just not incentivized for our long term health and well being. It is a pure capitalism.
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