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Omicron largely evades immunity from past infection or two vaccine doses

imperial.ac.uk

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Re: Omicron largely evades immunity from past infection or two vaccine doses

#91

Post by mygoodaccount »

sdeframond wrote: post #83
mygoodaccount wrote: post #72

What about both? I have both past infection and I'm double vaxxed. Based on the data, should I get boosted? From what I'm reading the answer is yes but does anybody have an estimation of my protection right now?

What do you have to loose?

Well I had a pretty bad second dose response. I was bedridden for a week. That said, my COVID infection was far worse and I'm still struggling with long COVID today.

I guess I'm going to have trouble taking a shot (active decision) I know I'll respond badly, albeit temporarily, to. As opposed to waiting around (passive decision) and trying my chances with COVID a second time.

Now that I'm writing this all out, I think I'll get my booster, maybe a fourth if I can weasel my way in.

Re: Omicron largely evades immunity from past infection or two vaccine doses

#92

Post by abduhl »

snewman wrote: post #86
abduhl wrote: post #63

Earlier quoted context omitted.

What you’re saying sounds correct, but is there any evidence that shows omicron is resulting in less serious illness/death because of the vaccines? The reports seem to indicate that the overall risk profile of omicron is lower including for unvaccinated people. Are we just parroting the same fact as for the alpha/delta variants without any substantial evidence here when we say vaccination helps avoid serious illness…

Hard information regarding serious illness / death from Omicron is scanty; it's still early. I've read indications that the vaccines (and/or previous infection with another variant, such as Delta) do seem to provide substantial protection against serious illness/death, but I don't have a link handy. IIRC at least some of the data we're working with is based on lab experiments of how various immune system components r…

Your argument boils down to “well the body learns what it looks like and so discriminates against similar looking viruses with more exposure allowing more targeted responses.” Under this theory, shouldn’t a natural immunity (as obtained from prior infection with alpha/delta) result in better immune response because it has learned “more” way to discriminate than the spike protein? Boosters seem inappropriate if the theory is to provide a wide database against which the immune system can check for similarities and associated response because they are targeted at the spike protein.

Re: Omicron largely evades immunity from past infection or two vaccine doses

#93

Post by jwineinger »

ugjka wrote: post #79
mygoodaccount wrote: post #72

What about both? I have both past infection and I'm double vaxxed. Based on the data, should I get boosted? From what I'm reading the answer is yes but does anybody have an estimation of my protection right now?

It is called hybrid immunity and it is much longer lasting https://www.news-medical.net/news/20211202/Hybrid-immunity-p... "The overall protection provided by two doses of ChAdOX1 was considerably lower than that given by BNT162b2. However, infection-acquired immunity boosted with vaccination-induced immunity remained high over a year after infection. Based on these observations, the authors recommend the strategic u…

Is there any indication if double-vax + exposure carries similar benefit?

My wife had 2x Pfizer and then she and our kids got delta. I had 2x Moderna and never had symptoms and tested negative 3 times. No quarantining whatsoever -- slept in the same bed as my wife, the kids still crawled all over me. I still got boosted a few weeks ago, but I've been curious if living in a sick-house with 100% certainty of exposure would carry its own booster effect.

Re: Omicron largely evades immunity from past infection or two vaccine doses

#94

Post by Retric »

dsmnd wrote: post #61
Retric wrote: post #34

Earlier quoted context omitted.

Vaccines can last your entire lifetime, but their effectiveness decays over time it largely depends on the disease and your risk of infection. Booster shots for various vaccines have been common for example, it’s recommended people take a Tdap booster every 10 years, Tetanus every 4-6 etc. The flu vaccine is a special case as it’s changed every year.

The 'T' in Tdap stands for tetanus

Yes, though to be clear your supposed to get a both.

“It is recommended that adults get a Tdap shot for one of their tetanus boosters.” https://www.verywellhealth.com/booster-shots-1298291

It simply reduces the number of injections when you get multiple vaccines at the same time.

Re: Omicron largely evades immunity from past infection or two vaccine doses

#95

Post by [deleted] »

marcosdumay wrote: post #90
throwaway_2009 wrote: post #66

Earlier quoted context omitted.

So they "mandate" a third dose, nothing happens long term, so they do a fourth lockdown, close some businesses again, do some travel bans, tell people to put things on their faces, nothing happens long term, so they "mandate" a fourth dose, do a fourth lockdown... And then the virus is still everywhere, it's still significantly more dangerous to be outside than it was in February 2020, and now it's a tremendous admin…

> everyone is terrified due to your big marketing campaign Yeah, a lot of people dying tends to terrify people.

[deleted]

Re: Omicron largely evades immunity from past infection or two vaccine doses

#96

Post by 13years »

marcosdumay wrote: post #90
throwaway_2009 wrote: post #66

Earlier quoted context omitted.

So they "mandate" a third dose, nothing happens long term, so they do a fourth lockdown, close some businesses again, do some travel bans, tell people to put things on their faces, nothing happens long term, so they "mandate" a fourth dose, do a fourth lockdown... And then the virus is still everywhere, it's still significantly more dangerous to be outside than it was in February 2020, and now it's a tremendous admin…

> everyone is terrified due to your big marketing campaign Yeah, a lot of people dying tends to terrify people.

The data has only trended in one direction since the beginning. The response continues to trend in exactly the opposite direction.

This is increasing apparent with Omicron.

Re: Omicron largely evades immunity from past infection or two vaccine doses

#97

Post by [deleted] »

marcosdumay wrote: post #90
throwaway_2009 wrote: post #66

Earlier quoted context omitted.

So they "mandate" a third dose, nothing happens long term, so they do a fourth lockdown, close some businesses again, do some travel bans, tell people to put things on their faces, nothing happens long term, so they "mandate" a fourth dose, do a fourth lockdown... And then the virus is still everywhere, it's still significantly more dangerous to be outside than it was in February 2020, and now it's a tremendous admin…

> everyone is terrified due to your big marketing campaign Yeah, a lot of people dying tends to terrify people.

[deleted]

Re: Omicron largely evades immunity from past infection or two vaccine doses

#98

Post by 13years »

triactual wrote: post #75
figaroniguzo wrote: post #5

Anecdotal but I currently have Omicron. I had COVID in March 2021 and got vaccinated in September. I have no symptom except back pain.

While anecdotal data isn’t very useful, it is good to remember that people actually do get this disease. It seems like it’s always at arms length in online discussions; that someone else will get it surely, probably due to some implied moral failing, but not OP. Thanks for sharing and I hope you get better soon.

> good to remember that people actually do get this disease.

Why does it continue to be significantly important to call this out when the trajectory places Omicron and possible future variants within the realms of cold/flu ?

Re: Omicron largely evades immunity from past infection or two vaccine doses

#100

Post by Mountain_Skies »

makomk wrote: post #15

This news came out shortly after the UK mandated proof of two vaccine doses (or a negative test, though there's some suspicion this option will be removed like in many other European countries) for access to nightclubs and other large events. It is also not surprising and was expected when the decision was taken. Between this and other recent news I don't think trust in the establishment is exactly high right now.

It's suspicious when "the science" suddenly aligns with long standing political dictates. That doesn't mean that it is wrong but certainly is justification for a heavy dose of additional skepticism. Governments have been especially flustered by naturally acquired immunity and now "the science" gives them what they have long desired to be able to dismiss natural immunity. That doesn't mean that "the science" is wrong but it sure is suspicious how often politics proceeds science when throughout most of history, it has reacted to it instead.

Omicron will do what it is going to do regardless of what "the science" or politicians have to say on the matter but politicians and those involved with "the science" have no one to blame but themselves for the public skepticism after they've indulged in many "noble" lies and misleading statements throughout the pandemic. The gaslighting after they're called out on previous lies or poorly thought out promises and predictions don't help either. Maybe they can try out "I was wrong" for once and get some of the credibility back instead of constructing even more elaborate excuses for their failures.

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