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Omicron largely evades immunity from past infection or two vaccine doses

imperial.ac.uk

31–40 of 161 posts

Re: Omicron largely evades immunity from past infection or two vaccine doses

#31

Does anyone understand why a third dose of the same vaccine improves immunity to Omicron? I'm willing to believe the empirical evidence that boosters make a meaningful difference, but I can't figure out intuitively why the same mRNA a third time helps to address this new spike.

[deleted]

Re: Omicron largely evades immunity from past infection or two vaccine doses

#32

Does anyone understand why a third dose of the same vaccine improves immunity to Omicron? I'm willing to believe the empirical evidence that boosters make a meaningful difference, but I can't figure out intuitively why the same mRNA a third time helps to address this new spike.

Maybe it is less about it being the 2nd or 3rd shot and more about how recently you received your last shot? I got my 2nd shot 7 months ago and we've already heard that protection fades over time, so maybe the booster just works because it boosts, not because it is really any different than my 2nd shot.

> Maybe is ... about how recently you received your last shot .. not because it is really any different than my 2nd shot.

No. That appears not be the situation. Immunity shortly after the thirds shot is substantially higher than shortly after the second

https://twitter.com/PaulMainwood/status/1460191035531878405

https://twitter.com/PaulMainwood/status/1458026852249919490

Re: Omicron largely evades immunity from past infection or two vaccine doses

#33

Does anyone understand why a third dose of the same vaccine improves immunity to Omicron? I'm willing to believe the empirical evidence that boosters make a meaningful difference, but I can't figure out intuitively why the same mRNA a third time helps to address this new spike.

In other industries they call this "sales": getting rid of current perishable stock before buying fresh one. It's there, we might as well use it.

I was going to call it “marketing.”

I am amazed to see people discuss what are essentially the marketing claims of a corrupt industry as if they had scientific validity.

Substitute the word “immunity” with “blockchain” or “Artificial Intelligence” and maybe more people would see through it.

Re: Omicron largely evades immunity from past infection or two vaccine doses

#34
post #20

Does anyone understand why a third dose of the same vaccine improves immunity to Omicron? I'm willing to believe the empirical evidence that boosters make a meaningful difference, but I can't figure out intuitively why the same mRNA a third time helps to address this new spike.

Is it not just timing? I thought the effectiveness of the vaccines only lasted around 6 months. In the US 18+ were able to get it 7 or 8 months ago.

Vaccines can last your entire lifetime, but their effectiveness decays over time it largely depends on the disease and your risk of infection. Booster shots for various vaccines have been common for example, it’s recommended people take a Tdap booster every 10 years, Tetanus every 4-6 etc.

The flu vaccine is a special case as it’s changed every year.

Re: Omicron largely evades immunity from past infection or two vaccine doses

#36

Does anyone understand why a third dose of the same vaccine improves immunity to Omicron? I'm willing to believe the empirical evidence that boosters make a meaningful difference, but I can't figure out intuitively why the same mRNA a third time helps to address this new spike.

In other industries they call this "sales": getting rid of current perishable stock before buying fresh one. It's there, we might as well use it.

You really think the CDC and other govt and NGO organizations, as an international coordinated group effort, are in bed with pharma companies, plotting with them to falsify data and craft false recommendations, just so those farma companies can make more $$? I mean, I actually do think that pharma companies are vile, have successfully gained significant regulatory capture, and can influence policy through their own messaging and lobbying, but this wouldn't be influence, this would be coordinated and crafted disinformation across many many parties, most of whom don't work for pharma at all.

Honestly this theory seems like absolute crazy talk. Especially when perfectly reasonable explanations exist like the fact that immunity from vaccines wanes over time.

When given option 1 (crazy, complicated, far fetched, zero evidence) and option 2 (simple, makes sense, lots of independent scientific parties agreeing), and you pick options 2... ???? I'm confused about how you pick #1.

Re: Omicron largely evades immunity from past infection or two vaccine doses

#37

Earlier quoted context omitted.

In other industries they call this "sales": getting rid of current perishable stock before buying fresh one. It's there, we might as well use it.

I was going to call it “marketing.” I am amazed to see people discuss what are essentially the marketing claims of a corrupt industry as if they had scientific validity. Substitute the word “immunity” with “blockchain” or “Artificial Intelligence” and maybe more people would see through it.

It isn't just pharma companies saying the booster is needed. Your framing seems willfully misleading.

Re: Omicron largely evades immunity from past infection or two vaccine doses

#38

Does anyone understand why a third dose of the same vaccine improves immunity to Omicron? I'm willing to believe the empirical evidence that boosters make a meaningful difference, but I can't figure out intuitively why the same mRNA a third time helps to address this new spike.

> Does anyone understand why a third dose of the same vaccine improves immunity to Omicron?

From what I've read, 2 doses in 8-12 weeks is a small separation, as these things go.

A third dose 6 months after the second is not just a third revision of the lesson (metaphorically), but a more appropriate spacing to re-enforce it.

Re: Omicron largely evades immunity from past infection or two vaccine doses

#39
post #15

This news came out shortly after the UK mandated proof of two vaccine doses (or a negative test, though there's some suspicion this option will be removed like in many other European countries) for access to nightclubs and other large events. It is also not surprising and was expected when the decision was taken. Between this and other recent news I don't think trust in the establishment is exactly high right now.

The sooner they mandate a third does the better. Not sure why this news would lower trust in the government, can you elaborate on that?

Re: Omicron largely evades immunity from past infection or two vaccine doses

#40

Earlier quoted context omitted.

In other industries they call this "sales": getting rid of current perishable stock before buying fresh one. It's there, we might as well use it.

I was going to call it “marketing.” I am amazed to see people discuss what are essentially the marketing claims of a corrupt industry as if they had scientific validity. Substitute the word “immunity” with “blockchain” or “Artificial Intelligence” and maybe more people would see through it.

Agreed. Came right from the CEO. What else was he suppposed to say? "Skip the booster, it barely helps."? Imagine the public panic, as well as the stock market panic.
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