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Omicron variant more resistant to vaccine but causes less severe Covid: study

washingtonpost.com

261–270 of 1001 posts

Re: Omicron variant more resistant to vaccine but causes less severe Covid: study

#261
post #13

The title is misleading. It is possible that Omicron is just as severe and that the effect in the study is because a large percentage of the population had some immunity from a previous infection or vaccine. > South Africa has a quite high seroprevalence of prior infection, particularly after delta, and in some parts of South Africa up to 80 percent of people were exposed to previous infection. We don’t think it’s a…

The study adjusted for vaccine status [0] but was still comparing things to the initial wave in 2020, which is strange and I would like to know their justification for that. For a bit more of an apples-to-apples comparison they should be comparing omicron hospitalization & fatality rates to those of non-omicron variants over the same period of time. It doesn't look like they've done that, and I'm not aware of a study…

Did they also adjust for previous infection?

Re: Omicron variant more resistant to vaccine but causes less severe Covid: study

#262
post #165
post #21

I have a question for anyone who has a serious level of knowledge on virus evolution: As viruses evolve over time is there any correlation to severity - do they have trade offs as they evolve? I am hoping that it would be some kind of trade off that the virus makes in that it can spread more easily but not be as severe (I understand that it is unlikely nature requires a trade-off). I ask as my concern is that while t…

Play with Plague Inc. ( https://www.ndemiccreations.com/en/22-plague-inc ) Every single press title the last two years can be related somehow to a single Game. New variants, new mutations, spreading faster vs killing more people, ... All these tradeoffs are quite well modeled. Building a resistance to vaccines ("the cure") is also one areas where your virus can evolve, and -to be honnest- I prefer it to fight vaccine…

It's a game, not a model. Real mutations aren't directed or instantly spread to all infected people like in the game. Iirc people also don't get better once infected.

Re: Omicron variant more resistant to vaccine but causes less severe Covid: study

#263

Earlier quoted context omitted.

We are maybe a couple months from Pfizer's new antiviral becoming widely available, and it will probably work for immune compromised people. There's also a recent EUA for a long-acting antibody PrEP injection that should help immune compromised people avoid infection in the first place. Both of these may be widely available in the US quite soon.

This is a good response and I think would be something that should be taken into account. I am still not going to start masking again unless a much more severe variant rises but I can understand setting a firm deadline based on an emerging technologies. Issue is that there will never be a 100% solution and some states more willing than others to let mandates run forever. What happens if those emerging technologies ar…

The Pfizer data on their new pill Paxlovid is very good. It's not emerging, it's here and will be available to people very soon. We will probably all get covid, wouldn't it be better if we all got it after treatments that cut deaths by 90% are widely available?

https://www.washingtonpost.com/health/2021/12/14/does-pfizer...

Re: Omicron variant more resistant to vaccine but causes less severe Covid: study

#264
post #46

Earlier quoted context omitted.

I havent seen any evidence covid is seasonal. it may become seasonal. but nothing in the past 2 years as indicated it is.

Have you seen infection/death charts? It peaks in winter and at its minimum in summer.

Have you seen the charts for India?

Re: Omicron variant more resistant to vaccine but causes less severe Covid: study

#265
post #13

The title is misleading. It is possible that Omicron is just as severe and that the effect in the study is because a large percentage of the population had some immunity from a previous infection or vaccine. > South Africa has a quite high seroprevalence of prior infection, particularly after delta, and in some parts of South Africa up to 80 percent of people were exposed to previous infection. We don’t think it’s a…

I don't think that it is misleading. The severity of a disease is relative to the current situation.

For example, it could be the case that Omicron is actually less infectious than the original variant, when compared in the setting of 2020. It spreads faster today because, (i) because of preexisting immunity most cases are very mild, and so lots of people become unwitting carriers, (ii) people have gone back to normal behavior after vaccination, and (iii) the vaccines inhibit the other variants much more than Omnicron. So Omicron gets more opportunities to infect and spread. Of course, all this is just conjecture and could be true or false.

What matters from a practical point of view is that, Omnicron is less severe in the general population today(for various reasons), as compared to the original strain back in 2020.

Re: Omicron variant more resistant to vaccine but causes less severe Covid: study

#266
post #219

Earlier quoted context omitted.

In the mean time we should do whatever we can to avoid filling hospitals to capacity.

Sounds good. 2 years on with enough vaccines and antiviral pills on the way if you still believe hospitals are "filled to capacity", I'd like what you're smoking.

I’m smoking a wadded-up copy of that Rolling Stone article about gunshot victims waiting for the ER.

Re: Omicron variant more resistant to vaccine but causes less severe Covid: study

#267
post #202

Earlier quoted context omitted.

It's interesting how Scotland, which kept a mask mandate, and England, which dropped it, affected cases. From start to end of October, cases per 100k, 7 day average Glasgow -- 300->220 Edinburgh -- 210->250 Manchester -- 290->220 Birmingham -- 250->280 4 similar cities, two with mask mandates, two without. And smaller ones Aberdeen -- 267->330 Southampton -- 300->410 Perth -- 320->260 Hereford -- 290->580 So there ma…

There are plenty of scientific studies showing that masks work.

But do they show how much mask mandates work in the real world, do they explain why Edinburgh and Glasgow are indistingishable from Mancehster and Birmingham in numbers of cases detected?

Re: Omicron variant more resistant to vaccine but causes less severe Covid: study

#268
post #224

This is honesty good news. The best case scenario is a new less deadly highly contagious strain that become the most dominant and spreads worldwide. Way too many comments and articles that try and keep the fear train running full steam. A mild strain of covid that is contagious, leads to natural immunity and doesn’t require a vaccine is an absolute win win for the world.

I agree. Maybe COVID has changed to be more cooperative with humanity (it's a good strategy for parasites to not kill their hosts).

How can a virus have a "strategy" when all which occurs are random mutations during replication? I wonder about this a lot.

Re: Omicron variant more resistant to vaccine but causes less severe Covid: study

#269

Earlier quoted context omitted.

I live in a state where mask mandates are essentially gone. Very few people wear masks here and they are not required in schools so only ~5% of kids are wearing them at my children's elementary school. Everything seems pretty good so far, no marked rise in cases and almost no cases in my kids school over the last year, maybe 25 total, all mild. I am in no way saying masks don't work, in fact I think that they do. Wit…

It's interesting how Scotland, which kept a mask mandate, and England, which dropped it, affected cases. From start to end of October, cases per 100k, 7 day average Glasgow -- 300->220 Edinburgh -- 210->250 Manchester -- 290->220 Birmingham -- 250->280 4 similar cities, two with mask mandates, two without. And smaller ones Aberdeen -- 267->330 Southampton -- 300->410 Perth -- 320->260 Hereford -- 290->580 So there ma…

There's already data that shows masks work.

https://med.stanford.edu/news/all-news/2021/09/surgical-mask...

Re: Omicron variant more resistant to vaccine but causes less severe Covid: study

#270
post #168

Earlier quoted context omitted.

Would you attend the game if it were 11 people? Because that's what you do every time you drive. 11 crash fatalities per 100,000 people. https://www.iihs.org/topics/fatality-statistics/detail/state...

Driving has benefits. Getting infected with COVID does not.

Yes. Pollution. Destruction of land. Serious injury. Noise. Urban sprawl.

So many benefits.

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