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Japanese scientists develop vaccine to eliminate cells behind aging

japantimes.co.jp

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Re: Japanese scientists develop vaccine to eliminate cells behind aging

#231

Post by zemvpferreira »

gumby wrote: post #229
obblekk wrote: post #194

1. Removing senescent cells extends life by 30-40% with huge quality of life improvements in the last 25% of the life (relative to control), in mice. This isn't an elimination of all aging, but quite a valuable thing regardless. Eventually, other causes of aging would kick in and still cause death, without a single senescent cell in your body (e.g. DNA methylation). 2. I believe all governments should create Warpspee…

> I believe all governments should create Warpspeed for this approach. What would that mean in practice?

Lots of money and no red tape.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#232

Post by slickrick216 »

freen wrote: post #196
slickrick216 wrote: post #165

Earlier quoted context omitted.

I hope this is satire. The medical industry doesn’t always have your best intentions at heart. From talcum powder to thalidomide. Be careful.

You assume thalidomide was intentional?

Not fully but it’s fair to say. greed plays a role in all human interactions. Organisational failure is a hard thing to pin down. Mix in the banality of evil and strange things can happen. Felix Hoffman the scientist at Bayer who is credited (somewhat disputed now) as discovering heroin and aspirin in the same week. He was just a chemist. The company was just out to make a profit. Crack epidemics in almost every country were the effect. Bit of a long winded way to say it doesn’t have to be black or white and to also that we can’t tell for sure the full effects of anything until well after.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#233

Post by bpodgursky »

gumby wrote: post #229
obblekk wrote: post #194

1. Removing senescent cells extends life by 30-40% with huge quality of life improvements in the last 25% of the life (relative to control), in mice. This isn't an elimination of all aging, but quite a valuable thing regardless. Eventually, other causes of aging would kick in and still cause death, without a single senescent cell in your body (e.g. DNA methylation). 2. I believe all governments should create Warpspee…

> I believe all governments should create Warpspeed for this approach. What would that mean in practice?

Accelerated FDA approvals (willingness to grant EUAs), fewer blocks around human trials, even just having the FDA respond faster and more definitively would be a huge improvement over their current opaque processes (waiting weeks to even get a response to an email).

Not to mention... funding.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#234

Post by [deleted] »

q1w2 wrote: post #223
obblekk wrote: post #194

1. Removing senescent cells extends life by 30-40% with huge quality of life improvements in the last 25% of the life (relative to control), in mice. This isn't an elimination of all aging, but quite a valuable thing regardless. Eventually, other causes of aging would kick in and still cause death, without a single senescent cell in your body (e.g. DNA methylation). 2. I believe all governments should create Warpspee…

This is essentially creating an auto-immune disease in old age - by having the body target it's own cells. It's also not clear how the researchers prevented the immune cells from dying in the Thymus (who's function is specifically to prevent immune cells from being coded to attack cells in the body - it's like a UAT environment). ...but the bigger question would be - If this protein encoded a protein that identified…

[deleted]

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#235

Post by 6510 »

majkinetor wrote: post #104
CorrectHorseBat wrote: post #85

Earlier quoted context omitted.

We are very risk averse of taking vaccines, while they are incredibly safe and barely have any risk associated with them. Probably more harm is done because people are too afraid of taking a vaccine than the opposite (not only looking at covid19 vaccines). The biggest harm done by taking vaccines you don't really need is probably that the money could have been used for something more useful.

Barely have any acute risk. Its almost impossible to find out what happens after long time, say a decade, with the current approach. > The biggest harm done by taking vaccines you don't really need is probably that the money could have been used for something more useful. What kind of nonsense is that? Its the same as saying "there is no problem in taking any drug, the worst it can get is lose some money". You can't…

It makes a truly boring person if everything that is unknown must QUICKLY be asserted to be true or false.

One should actively question all things again and again. Most things we believe to be true are just true because we have no reason to think they are false.

Hell, most here write some code, look at it, it looks fine? Then it doesn't run because there are one or more typos. Note here how the whole thing doesn't work. If you organize your life like that the whole thing wont work.

I so often told people to ask anyway in stead of already "knowing" what someone is going to say. Even if you are 95% certain you are still 100% wrong. If you do life like that you will never find a book you like, a job, a partner, a place to vacation, an interesting new food, a pet, a study. There is no need to bother, you already "know", they are all just going to disappoint you.

God might be real, Trump might be a woman, Aliens might walk the earth, people might be living on mars, someone might have a working antikythera mechanism in their private collection, King Enmen-lu-ana might have ruled for 43,200 years, he might have visited the martians in his Vimana.

What would I know about it?

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#236

Post by cblconfederate »

majkinetor wrote: post #114
netizen-936824 wrote: post #57

Earlier quoted context omitted.

Really? Because they get experimented on and then slaughtered by the thousands

You forgot tiny detail that they live in prison for entire life eating equivalent of Mc Donalds or worse.

by mouse life standards, they live like kings

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#237

Post by cblconfederate »

kevinalexbrown wrote: post #66
pezzana wrote: post #32

> The team, including Juntendo University professor Toru Minamino, confirmed that mice administered with the vaccine showed decreases in the zombie cells, medically known as senescent cells, and in areas affected by arterial stiffening. By now this has become a trope. "Researchers develop new treatment for {UNTREATED_DISEASE}" ... in mice. Mouse models of human disease are very limited in their predictive ability. Th…

Yes and this response has also become a trope. It’s generically universal to nearly any early result.

developers expect scaling up to be like Ctrl-C Ctrl-V

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#238

Post by Synaesthesia »

obblekk wrote: post #194

1. Removing senescent cells extends life by 30-40% with huge quality of life improvements in the last 25% of the life (relative to control), in mice. This isn't an elimination of all aging, but quite a valuable thing regardless. Eventually, other causes of aging would kick in and still cause death, without a single senescent cell in your body (e.g. DNA methylation). 2. I believe all governments should create Warpspee…

Maybe instead of maximising GDP we should maximise happiness and there's plenty of low hanging fruit. I mean people are still starving to death and dying of preventable diseases...

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#239

Post by cblconfederate »

_ph_ wrote: post #159
pezzana wrote: post #32

> The team, including Juntendo University professor Toru Minamino, confirmed that mice administered with the vaccine showed decreases in the zombie cells, medically known as senescent cells, and in areas affected by arterial stiffening. By now this has become a trope. "Researchers develop new treatment for {UNTREATED_DISEASE}" ... in mice. Mouse models of human disease are very limited in their predictive ability. Th…

I keep wondering if future generations will assume we had a special worship for mice considering how many diseases we tried to cure in mice :p

the first engineered superintelligent mouse will discover that humans have solved all his problems and will make a mouse pharma empire out of their discoveries.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#240

Post by cblconfederate »

pcrh wrote: post #208
Waterluvian wrote: post #58

Earlier quoted context omitted.

This is well known and very well established. We don’t like experimenting on humans. It’s kind of ghoulish and evil. I get what you’re saying but it’s safe to assume that this concept is already baked into almost everyone’s discussion on matters like this.

>It’s kind of ghoulish and evil. Experiments on humans happen very frequently. They're called "clinical trials".

or A/B tests
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