Japanese scientists develop vaccine to eliminate cells behind aging • Hacker News Board

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#181

Post by cipheredStones » Sun, Dec 12, 2021, 9:20 PM UTC

tux3 wrote: post #155

pas wrote: post #151

Earlier quoted context omitted.

Do we know how exactly this happens? How fast this process "converges"? How big is the search space and how fast new candidates are generated?

About 3e11 combinations are possible, about 10 billions different antibodies will be generated by a human body (numbers I just sourced from Wikipedia). The shuffling is done by recombination, which means joining segments of DNA in a random fashion (a similar recombination process is actually used for DNA repair, though with somewhat less randomness!) There's a lot more to say about all of this, but I don't know how m…

(10 billion (1e9) / 3e11 ~= 3%, for those like me who don't have powers of 10 memorized.)

Does that imply that there's a good chance someone's immune system will just fail to generate any appropriate antibodies against a novel intruder? Or does the "fuzzy matching" aspect mean that exploring a small percentage of the space mean you're very likely to get at least some degree of success?

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#182

Post by saltyfamiliar » Sun, Dec 12, 2021, 9:21 PM UTC

hasmolo wrote: post #9

kiba wrote: post #4

Earlier quoted context omitted.

It's probably not a good idea to get every single vaccines that's not recommended to you by the CDC/your doctor. Vaccines could potentially trigger some dangerous side effects, however rare it is.

don't drive cars, they can crash and it can be fatal while having other side effects, however rare they are.

Cars are the worst. Side effects include air pollution, cancer, death of nearby pedestrians, municipal neglect of sidewalks, extreme inefficiency of resources resulting from rolling around a 2000 pound hunk of metal for every 180 pound person that wants get anywhere, sprawling asphalt deserts, weight gain and death. Don't bother contacting anyone if you experience one or more of these symptoms.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#183

Post by bavell » Sun, Dec 12, 2021, 9:24 PM UTC

mlyle wrote: post #152

NullPrefix wrote: post #109

Earlier quoted context omitted.

Wouldn't that make you an antivaxxer? You surely don't want to be mixed up with that crowd, do you?

If someone has a demonstrated reaction to the vaccine -- e.g. much worse blood sugar levels -- they can rationally decide that they may not want to get another dose based on an earnest assessment of the risk from not getting dosed vs. the risk of getting dosed. People with e.g. allergies to polysorbate choosing not to get vaccinated are not "antivaxxers".

I completely agree with you but I think OP is poking fun at the overzealousness of some people accusing others of being anti-vax when the covid vaccines are the only ones those people oppose. Of course there are actual antivaxxers out there who believe in microchips, etc but now even people who have gotten the vaccine but oppose mandates are labelled "antivaxxers" by dictionaries these days: https://www.merriam-webster.com/dictionary/anti-vaxxer

I wish we could have a rational discussion around these topics without accusations being fired back and forth in bad faith. It just drives people further into their existing positions and hardens them to criticism.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#184

Post by devmunchies » Sun, Dec 12, 2021, 9:28 PM UTC

dr_dshiv wrote: post #26

JohnJamesRambo wrote: post #2

Sign me up for this the second it is available. As an aside, to spite anti vaxxers I’m on a mission to get every vaccine I can. I want my bloodstream to be like the Library at Alexandria before it burned down.

I’m with you. I’ve gotten vaccinated for everything my doctor lets me. Japanese Encephalitis? Pshaw. I don’t even know what it is, but good luck with my immune system. It’s like getting a superpower in a video game! And, vaccines have general positive effects of health: https://ec.europa.eu/research-and-innovation/en/horizon-maga...

> It’s like getting a superpower in a video game

It’s more like rare candy in Pokémon, which isn’t as good as naturally leveling up your Pokémon.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#185

Post by junon » Sun, Dec 12, 2021, 9:29 PM UTC

bavell wrote: post #178

junon wrote: post #174

Earlier quoted context omitted.

I wish I had the time to make a chrome extension that replaced all usages of "big pharma" with "a thing I don't personally understand but hand-wave away because I refuse to do proper research on my own". It would make such comments much more meaningful and honest.

Does this apply to all usages of "Big Tech" as well? Or is that different?

Depends on the context. "Big Tech" can mean working for a large, often FAANG company. But there are markedly less conspiracies cooked up about big tech than there are about big pharma.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#186

Post by userbinator » Sun, Dec 12, 2021, 9:31 PM UTC

hasmolo wrote: post #9

kiba wrote: post #4

Earlier quoted context omitted.

It's probably not a good idea to get every single vaccines that's not recommended to you by the CDC/your doctor. Vaccines could potentially trigger some dangerous side effects, however rare it is.

don't drive cars, they can crash and it can be fatal while having other side effects, however rare they are.

I don't know anyone who finds getting vaccinated to be pleasurable, unlike driving.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#187

Post by mlyle » Sun, Dec 12, 2021, 9:32 PM UTC

bavell wrote: post #183

mlyle wrote: post #152

Earlier quoted context omitted.

If someone has a demonstrated reaction to the vaccine -- e.g. much worse blood sugar levels -- they can rationally decide that they may not want to get another dose based on an earnest assessment of the risk from not getting dosed vs. the risk of getting dosed. People with e.g. allergies to polysorbate choosing not to get vaccinated are not "antivaxxers".

I completely agree with you but I think OP is poking fun at the overzealousness of some people accusing others of being anti-vax when the covid vaccines are the only ones those people oppose. Of course there are actual antivaxxers out there who believe in microchips, etc but now even people who have gotten the vaccine but oppose mandates are labelled "antivaxxers" by dictionaries these days: https://www.merriam-webst…

> I wish we could have a rational discussion around these topics without accusations being fired back and forth in bad faith. It just drives people further into their existing positions and hardens them to criticism.

Well, trying to "poke fun" like this, with Poe's law being what it is, does nothing to bring the temperature down.

Our choices are:

* "Poking fun" is intended and this is likely to provoke people who label others as antivax without adding anything to the discussion.

* or this is sincere.

Neither is a great look.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#188

Post by Glench » Sun, Dec 12, 2021, 9:32 PM UTC

junon wrote: post #174

ekianjo wrote: post #94

Earlier quoted context omitted.

> And, vaccines have general positive effects of health: https://ec.europa.eu/research-and-innovation/en/horizon-maga ... If you believe that vaccines may have potentially positive effects beyond their original scope, you must also be ready for the opposite, potential negative effects beyond their original scope. If you don't, you are just being brainwashed by big Pharma.

I wish I had the time to make a chrome extension that replaced all usages of "big pharma" with "a thing I don't personally understand but hand-wave away because I refuse to do proper research on my own". It would make such comments much more meaningful and honest.

Here you go chief: https://chrome.google.com/webstore/detail/replacerator/gaajh...

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#189

Post by devmunchies » Sun, Dec 12, 2021, 9:33 PM UTC

postsantum wrote: post #35

JohnJamesRambo wrote: post #2

Sign me up for this the second it is available. As an aside, to spite anti vaxxers I’m on a mission to get every vaccine I can. I want my bloodstream to be like the Library at Alexandria before it burned down.

That's tribal thinking, "us vs them". You want to spite "them", who ostensibly don't know a thing about vaccine, but you never bothered to learn it yourself

The worse part is that anti-vax can just mean anti-mandate. Spiting in that context doesn’t make any sense since anti-vaxers still believe in effectiveness of vaccines.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#190

Post by germinalphrase » Sun, Dec 12, 2021, 9:38 PM UTC

InvaderFizz wrote: post #122

ogwh wrote: post #67

Earlier quoted context omitted.

Tell that to my hair follicles.

I started supplementing testosterone for reasons unrelated to hair loss. It has completely stopped and even reversed my thinning on top after just a few months.

Presumably under the direction of a doctor?