Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Japanese scientists develop vaccine to eliminate cells behind aging

japantimes.co.jp

Post reply on HN
Print view View original

171–180 of 382 posts

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#171

Post by brutuscat »

mmastrac wrote: post #87
tux3 wrote: post #64

Earlier quoted context omitted.

You have antibodies that will bind to just about anything foreign, including viruses that your body has never seen before, M-type immunoglobulin (IgM). It's the kind of antibodies that responds in the first phases of an infection. The problem is that IgMs are not very specific. They bind to a lot of things, but they bind poorly. In the library of Alexandria analogy, it's like a book that happens to mention a subject…

Is there a good resource to learn more about this without a Biology degree? I always assumed the body generated matching snippets at random and the law of large numbers would result in a match eventually.

This book was written by makers of the Kurzgesagt's YouTube channel recently.

https://www.amazon.com/-/es/gp/aw/d/0593241312/ref=tmm_hrd_s...

Pretty cool illustrations too.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#172

Post by junon »

BurningFrog wrote: post #131
blip54321 wrote: post #7

Earlier quoted context omitted.

You already have the Library of Alexandria. That's your lymph nodes. What vaccines do is move some books to the front of the building, so your dentritic cells don't have to spend a few days finding them. You want the right books at the front. A mission to move all the books to the front is perhaps misguided.

That implies that each new vaccine diminishes other immunities, making it a zero sum game. Is that actually how it works in any sense?

No, the analogy doesn't really stand up tbh.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#173

Post by contravariant »

blip54321 wrote: post #7
JohnJamesRambo wrote: post #2

Sign me up for this the second it is available. As an aside, to spite anti vaxxers I’m on a mission to get every vaccine I can. I want my bloodstream to be like the Library at Alexandria before it burned down.

You already have the Library of Alexandria. That's your lymph nodes. What vaccines do is move some books to the front of the building, so your dentritic cells don't have to spend a few days finding them. You want the right books at the front. A mission to move all the books to the front is perhaps misguided.

The lymph nodes are more like the library of babel, endlessly toiling to find those rare 'books' that actually contain meaningful information.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#174

Post by junon »

ekianjo wrote: post #94
dr_dshiv wrote: post #26

Earlier quoted context omitted.

I’m with you. I’ve gotten vaccinated for everything my doctor lets me. Japanese Encephalitis? Pshaw. I don’t even know what it is, but good luck with my immune system. It’s like getting a superpower in a video game! And, vaccines have general positive effects of health: https://ec.europa.eu/research-and-innovation/en/horizon-maga...

> And, vaccines have general positive effects of health: https://ec.europa.eu/research-and-innovation/en/horizon-maga ... If you believe that vaccines may have potentially positive effects beyond their original scope, you must also be ready for the opposite, potential negative effects beyond their original scope. If you don't, you are just being brainwashed by big Pharma.

I wish I had the time to make a chrome extension that replaced all usages of "big pharma" with "a thing I don't personally understand but hand-wave away because I refuse to do proper research on my own".

It would make such comments much more meaningful and honest.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#175

Post by natded »

JohnJamesRambo wrote: post #2

Sign me up for this the second it is available. As an aside, to spite anti vaxxers I’m on a mission to get every vaccine I can. I want my bloodstream to be like the Library at Alexandria before it burned down.

We are going to see just how much people love The Science when they make mRNA vaccine to cure homosexuality.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#176

Post by tux3 »

dr_dshiv wrote: post #170
tux3 wrote: post #76

Earlier quoted context omitted.

I'm not going to tell you that you're wrong, but I would be more careful than that. Infections can be the trigger for auto-immune diseases. We're not sure precisely how, but there seems to be a complex combination of genetic and environmental factors. Your immune system is very much not playing games, it's in the business of reacting on a hair trigger, and doing more damage to foreign bodies than it does to your own…

This would be like being worried about playing outside and being exposed to germs. Yes, it’s true that every new infection has the possibility of killing you. But, now we have evidence that exposure to diverse mild pathogens actually makes your immune system less dangerous to the self. Otherwise it would be safer to live in a clean room.

I agree you should not try to live in a clean room, and you shouldn't be worried about being exposed to normal amount of germs.

When you say "exposure to diverse mild pathogens actually makes your immune system less dangerous to the self", I suspect you're referring to the hygiene hypothesis that has become part of popular culture.

It's important to know that that hypothesis, nowadays, is about early exposure to benign microbes. Meaning from in utero exposure to early childhood at the latest.

I have seen no evidence that voluntarily exposing yourself to pathogens is a good idea. The point to my post was that you shouldn't understand the immune system like an RPG element that needs training to level up.

Please do get vaccinated for relevant diseases, but I would not go too far in the direction of treating your immune system like a safe thing to play with.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#177

Post by sova »

mmastrac wrote: post #87
tux3 wrote: post #64

Earlier quoted context omitted.

You have antibodies that will bind to just about anything foreign, including viruses that your body has never seen before, M-type immunoglobulin (IgM). It's the kind of antibodies that responds in the first phases of an infection. The problem is that IgMs are not very specific. They bind to a lot of things, but they bind poorly. In the library of Alexandria analogy, it's like a book that happens to mention a subject…

Is there a good resource to learn more about this without a Biology degree? I always assumed the body generated matching snippets at random and the law of large numbers would result in a match eventually.

Tangentially relevant is the way CRISPR works, and I would recommend the Nobel acceptance speeches by Jennifer Doudna and Charpentier.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#178

Post by bavell »

junon wrote: post #174
ekianjo wrote: post #94

Earlier quoted context omitted.

> And, vaccines have general positive effects of health: https://ec.europa.eu/research-and-innovation/en/horizon-maga ... If you believe that vaccines may have potentially positive effects beyond their original scope, you must also be ready for the opposite, potential negative effects beyond their original scope. If you don't, you are just being brainwashed by big Pharma.

I wish I had the time to make a chrome extension that replaced all usages of "big pharma" with "a thing I don't personally understand but hand-wave away because I refuse to do proper research on my own". It would make such comments much more meaningful and honest.

Does this apply to all usages of "Big Tech" as well? Or is that different?

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#179

Post by speedcoder »

eezurr wrote: post #135

The day we escape death will begin the descent into the longest dark age humanity will ever experience. Death is necessary to allow new ideas and change to be brought into the world. Death is necessary to prevent wealth and power accumulating into fewer hands. Death is necessary for others to enjoy the right to bear and raise children. EDIT: 2 minutes go by and this comment has already been downvoted 3+ times. At lea…

Hmm. Do you mean to imply an external Dorian Gray effect may happen: https://en.m.wikipedia.org/wiki/The_Picture_of_Dorian_Gray? Wonder if there would be any other biological intra-cellular or inter-cellular Dorian Gray effects that may happen? Or, if this may really be a new free lunch.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#180

Post by mmastrac »

sova wrote: post #177
mmastrac wrote: post #87

Earlier quoted context omitted.

Is there a good resource to learn more about this without a Biology degree? I always assumed the body generated matching snippets at random and the law of large numbers would result in a match eventually.

Tangentially relevant is the way CRISPR works, and I would recommend the Nobel acceptance speeches by Jennifer Doudna and Charpentier.

I found a speech by Jennifer Doudna here: https://www.youtube.com/watch?v=KSrSIErIxMQ

Listening now, thanks!

Post reply on HN