BNT162b2 Vaccine Booster and Mortality Due to Covid-19
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Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19
#2TLDR it works as expected.
Participants who received a booster at least 5 months after a second dose of BNT162b2 had 90% lower mortality due to Covid-19 than participants who did not receive a booster.
Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19
#3Here's a summary, quoted from the article:
> RESULTS
> A total of 843,208 participants met the eligibility criteria, of whom 758,118 (90%) received the booster during the 54-day study period. Death due to Covid-19 occurred in 65 participants in the booster group (0.16 per 100,000 persons per day) and in 137 participants in the nonbooster group (2.98 per 100,000 persons per day). The adjusted hazard ratio for death due to Covid-19 in the booster group, as compared with the nonbooster group, was 0.10 (95% confidence interval, 0.07 to 0.14; P> CONCLUSIONS
> Participants who received a booster at least 5 months after a second dose of BNT162b2 had 90% lower mortality due to Covid-19 than participants who did not receive a booster.
This paper can't take omicron into account, but, it's definitely good news. I'll take a 90% lower mortality rate any day.
Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19
#4Is the control group composed of fully (2 dose) vaccinated individuals only? Or do they put non vaccinated people in there as well? I couldn't figure it out.
Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19
#5Given that boosters are an attempt to counteract waning vaccine vaccine effectiveness, there are two fundamental questions:
1. Do boosters work at all?
2. Do boosters wane over time, just like the original shots did?
They answer only 1. They didn't even attempt to shed light on 2, which is a serious letdown. Given known waning vaccine effectiveness, at a minimum claims on booster effectiveness should be bracketed by time since boosting event.
Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19
#6TLDR it works as expected. Participants who received a booster at least 5 months after a second dose of BNT162b2 had 90% lower mortality due to Covid-19 than participants who did not receive a booster.
Although the 3 per 100,000 death rate after 2 vaccinations is already very low. It's great that an additional vaccination would reduce it further, but after 2 vaccinations does it make sense to mandate a booster with these risk profiles?
Especially given that there are rare heart inflammation issues caused by the vaccine, I can see people having a difference of opinion about whether the booster is worth it compared to the risk, until the error bars on the risk measurement are narrowed down a bit.
Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19
#7Is the control group composed of fully (2 dose) vaccinated individuals only? Or do they put non vaccinated people in there as well? I couldn't figure it out.
> We obtained data for all members of Clalit Health Services who were 50 years of age or older at the start of the study and had received two doses of BNT162b2 at least 5 months earlier.
Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19
#8Is it too early to conclude whether booster effectiveness will also wane in 6 months?
I had some mild but persistent side effects from the second Pfizer dose (ear ringing and Eustachian tube dysfunction). It's gotten about 98% better - but not 100% - and I'm a bit nervous about the booster given that many people are reporting the side effects are somewhat more intense than the second shot.
If the booster is the final answer, maybe I'll take the risk. Not sure what I'll do though, if the new status quo is a booster required every 6 months, and you become a pariah in polite society if you're not "fully vaccinated"...
Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19
#9Is it too early to conclude whether booster effectiveness will also wane in 6 months? I had some mild but persistent side effects from the second Pfizer dose (ear ringing and Eustachian tube dysfunction). It's gotten about 98% better - but not 100% - and I'm a bit nervous about the booster given that many people are reporting the side effects are somewhat more intense than the second shot. If the booster is the final…
Data is showing T cell response is great from 2 doses so you won’t be a burden on the hospital. Looking like cases will diverge from hospitalizations soon and vaccinations will move to flu-like in “strongly encouraged and taken up by the responsible”
Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19
#10Given that boosters are an attempt to counteract waning vaccine vaccine effectiveness, there are two fundamental questions: 1. Do boosters work at all? 2. Do boosters wane over time, just like the original shots did? They answer only 1. They didn't even attempt to shed light on 2, which is a serious letdown. Given known waning vaccine effectiveness, at a minimum claims on booster effectiveness should be bracketed by…
It hasn't been long enough, they will probably do another paper in six months once that data is available.