I don't yet know enough about the single founder bit, but there is one unrelated sentence that you write that gives me great pause in the way you chose to write it: "But, if you want to do something big in the tech sector, you absolutely must be in SV for the connections, money, talent, etc." Really? You "absolutely must" be in SV? Seems like Groupon, Foursquare, Groupme, Bitly, Grubhub, Gawker, Gilt, Kickstarter, Am…
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Sidebar: Of course, if you're going to go for a different type of startup than YC's particular brand, you can do it from anywhere (central Japan, for instance). The article refers to such startups as a "lifestyle businesses". I find this terminology hilarious considering the most prominent example of a "lifestyle business" in our field has funded a racecar build by advanced beings for one of its founders.