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Viagra Is Linked to Almost 70% Lower Risk of Alzheimer's

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Re: Viagra Is Linked to Almost 70% Lower Risk of Alzheimer's

#12

Post by fer »

waterhouse wrote: post #9
galaxyLogic wrote: post #4

Earlier quoted context omitted.

Having a partner might lower the risk of Alzheimer's because having someone to talk to keeps your mind in a working condition. But also, taking Viagra means you are more likely to have sex and having sex might be the thing brain needs for "exercise". I find it somewhat hilarious to think that soon the Covid vaccine infomercials might be extended with "To keep you safe also remember to have sex" .

Or: Developing Alzheimer's makes you less interested in sex, makes your partner less interested in sex with you (possibly via creating problems with the relationship), and/or otherwise creates obstacles to sex.

That was actually my first thought.

The link talks about 70% decrease of Alzheimer risk over a 6 year period of Viagra use (vs lack thereof).

But early Alzheimer signs have been shown to appear up to 18 years before diagnosis. Memory and thinking tests for these signs from 13 to 18 years before diagnosis show 85% higher risk in those failing. [0]

So 6 years is actually a very short window to claim causality, especially when it can be guessed through other means with (my guess) higher accuracy.

[0] https://www.alzheimers.org.uk/research/care-and-cure-researc...

Re: Viagra Is Linked to Almost 70% Lower Risk of Alzheimer's

#13

Post by raducu »

version_five wrote: post #2

This is very interesting. The article points out twice that there is no evidence it's causal, but does proposr some potential causal mechanisms, all told a pretty reasonable summary of the finding. I'm curious to know if there is any info related to alzheimers and sex drive. The 70% is based on chance developing alzheimers in the next six years, I wonder if there is any relation between a profile who would seek Viagr…

I have a funny/sad/gross anecode: my flat neighbor had alzheimer's and I helped his wife for a few years, but really nothing much/special -- just getting him out of bed or off the toilet when he wouldn't budge (I can only imagine what his wife went through).

But very frequently when he was on the toilet he would play with his erm... sword and unsheathe it (Easter Europe, I'm cut, he wasn't) and his wife asked me why he did that?

And I was like.... "erm.... I think that question is overdue by about 40 years.."

Re: Viagra Is Linked to Almost 70% Lower Risk of Alzheimer's

#14

Post by perth »

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036338/

Viagra increases testosterone?

I wonder if this relates to other things that increase late-life testosterone like red meat (unprocessed)?

https://www.alzdiscovery.org/cognitive-vitality/blog/does-ea...

I've always thought about how big of a role testosterone plays in later-life health and I wonder why doctors don't prescribe it to restore testosterone levels to a normal (for a younger person) level to prevent osteoporosis and other hormone-linked diseases. Not saying this conclusion in the article is related to testosterone, but I have to speculate on it.

Re: Viagra Is Linked to Almost 70% Lower Risk of Alzheimer's

#15

Post by JamesBarney »

Most of the time these correlation studies are bunk. But I'm cautiously optimistic about this one because

1. The effect is huge.

2. Phospodiesterase is heavily expressed in neural and glial cells

3. There are a ton of alzheimers rodent RCTs with positive results.

Re: Viagra Is Linked to Almost 70% Lower Risk of Alzheimer's

#16

Post by swader999 »

Red light on your nutsack for ten minutes with wavelengths of 660nm and or 850nm a few times a week is just as effective for the getting old, decreasing boner issues.

Another trick is to form a fist and put it between your legs at your knees and squeeze your legs as hard as you can trying to crush your fist. You might feel a slight pop and things should work better after a few seconds of squeezing your fist.

Re: Viagra Is Linked to Almost 70% Lower Risk of Alzheimer's

#18

Post by JamesBarney »

perth wrote: post #14

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036338/ Viagra increases testosterone? I wonder if this relates to other things that increase late-life testosterone like red meat (unprocessed)? https://www.alzdiscovery.org/cognitive-vitality/blog/does-ea... I've always thought about how big of a role testosterone plays in later-life health and I wonder why doctors don't prescribe it to restore testosterone levels to a…

They do, but they're reluctant because there is evidence it increases risk of stroke and bad cardiovascular outcomes.

And most of the apparent benefits of testosterone look to be more correlational than causational. (except osteoporosis, and sarcopenia)

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