New cancer therapy holds potential to switch off major cancer types
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Re: New cancer therapy holds potential to switch off major cancer types
#2Here is the research:
Small-molecule inhibitors that disrupt the MTDH–SND1 complex suppress breast cancer progression and metastasis https://www.nature.com/articles/s43018-021-00279-5
Pharmacological disruption of the MTDH–SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer https://www.nature.com/articles/s43018-021-00280-y
Re: New cancer therapy holds potential to switch off major cancer types
#3> “You can’t find a drug target better than this: MTDH is important for most major human cancers, not important for normal cells, and it can be eliminated with no obvious side effects,” said Kang.
Re: New cancer therapy holds potential to switch off major cancer types
#4So what is, or are, the "small-molecule inhibitors"? (I don't have access to the full texts of the papers.)
Also, what makes them confident these inhibitors "suppress breast cancer progression and metastasis"? Does this mean only in the mouse model? Because the original article says "will be ready for human trials in a few years".
Re: New cancer therapy holds potential to switch off major cancer types
#5Nicely written, well explained and let’s hope that the MTDH will help in suppressing cancer. Not yet available, but their hard work will soon pay out.
> “I hope we’ll be ready for clinical trials in human patients in two to three years,”
Re: New cancer therapy holds potential to switch off major cancer types
#6"Because while it’s important to show that mice born without MTDH are resistant to cancer, that doesn’t help patients, whose genes can’t be rewritten."
...yet
Wonder if we'll look back at this and think "how quaint".
Re: New cancer therapy holds potential to switch off major cancer types
#7"Because while it’s important to show that mice born without MTDH are resistant to cancer, that doesn’t help patients, whose genes can’t be rewritten ." ...yet Wonder if we'll look back at this and think "how quaint".
Epigenetics are very easy to alter with peptides
Re: New cancer therapy holds potential to switch off major cancer types
#8"Because while it’s important to show that mice born without MTDH are resistant to cancer, that doesn’t help patients, whose genes can’t be rewritten ." ...yet Wonder if we'll look back at this and think "how quaint".
Actually, we can: I think we already have working gene therapy for several diseases.
Just look at the current list on wikipedia: https://en.wikipedia.org/wiki/Gene_therapy#Treatment_of_gene...
Re: New cancer therapy holds potential to switch off major cancer types
#9"Because while it’s important to show that mice born without MTDH are resistant to cancer, that doesn’t help patients, whose genes can’t be rewritten ." ...yet Wonder if we'll look back at this and think "how quaint".
Neo: “Are you trying to tell me that I can alter DNA?”
Morpheus: “no Neo, I’m trying to tell you that when you’re ready you won’t have to”
Altering the DNA is unnecessary if you can control the expression of genes or add additional genetic material later in the DNA->RNA->protein process. mRNA vaccines are already a great example of this. Another example might be the cystic fibrosis therapy Trikafta.
Re: New cancer therapy holds potential to switch off major cancer types
#10The Chinese military are spending vast vast sums on gene therapy.
They call it precision medicine.