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New Concerning Variant: B.1.1.529

yourlocalepidemiologist.substack.com

251–260 of 432 posts

Re: New Concerning Variant: B.1.1.529

#251
post #91

Earlier quoted context omitted.

All current evidence is that masks have a minor effect, measured in tiny fractions of a percent. https://vinayprasadmdmph.substack.com/p/do-masks-reduce-risk ... To date, I'm aware of no study that has quantified a difference in infection, hospitalization or death that is attributable to travel bans.

> To date, I'm aware of no study that has quantified a difference in infection, hospitalization or death that is attributable to travel bans. Why would you need a study to tell you that if nobody with covid travels to a country, that country remains covid-free? Perhaps you are unaware, but there are countries on this planet that covid hasn't gotten to, and those countries have travel bans.

Yup, this is such a huge pet peeve of mine. Throwing away science in the name of empiricism. What I mean by that is that science is about understanding the world by being able to make certain empirically verified models (mathematical usually), and then using the validated models (such as the germ theory of disease) to predict what the results would be even if we haven’t already measured that exact thing.

Like, because of an experiment done on Wednesday, a piece of meat kept carefully covered with metal is not going to sprout maggots and flies. Because maggots and flies are caused by flies laying eggs. That same piece of knowledge can then be used to predict with decent certainty that you’re still not going to sprout maggots and flies if you cover it with glass instead of metal and do it on a Tuesday.

Germ theory of diseases says if you quarantine travel, you can prevent (or reduce probability of) novel COVID diseases sprouting up in your country. Because the disease is caused by germs carried by infected people during the few weeks they’re contagious. You don’t need an exact study to prove that, although it’d certainly be nice.

Seriously. Empiricism is great. Using a kind of mindless empiricism (“models don’t tell you anything, so unless every situation is measured, you have no idea”) to throw doubt on science is not.

Re: New Concerning Variant: B.1.1.529

#253

Earlier quoted context omitted.

I don't disagree with you on the effectiveness of masks but tuberculosis bacterial cells are far larger than coronavirons.

Coronavirus itself isn't airborne, it travels in aerosolized water droplets, which are significantly larger than coronavirus itself.

But which are in the airbourne size range.

Re: New Concerning Variant: B.1.1.529

#254
post #203
post #199

Earlier quoted context omitted.

We cannot do the science, because such a randomized test would be deeply unethical. Compare to having pregnant women smoke cigarettes to study effect on the fetus. You do this only afterwards with observational data. Next to politization there is also public health, which is more of a management science than an emperical science. And economic concerns. From all the data worldwide, you only reduce risk of hospitalizat…

> We cannot do the science, because such a randomized test would be deeply unethical. Thank you for perfectly illustrating the problem. I was actually sort of worried that people wouldn't take me seriously when I said that science has become so political that we actually can't do any . It sounds conspiratorial, doesn't it? But, alas: 1) I post results of RCTs showing that masks do little, if anything. 2) Someone repl…

It is unethical. All your accusations of narrow-mindedness, but you can't see the obvious, glaring ethical problems with such a trial.

Not the least because it would be completely infeasible. You may pretend that we can "simply" do a "controlled experiment" but you ignore how impossible it is to tell any sizeable group of people to behave in a certain way and report honestly about it.

"Randomised control trials" are the platonic ideal but in the real world, you can't endanger people for your curiosity, and you will have greatest problems to actually enforce your test protocol. It's more than "tricky". Unless you have access to some spherical people in a vacuum.

Re: New Concerning Variant: B.1.1.529

#255
post #124

Earlier quoted context omitted.

Except there's hope of finding a more effective treatment against this virus while we are on pause. So lives can be saved potentially.

We did. We have multiple vaccines and treatments. That was the end game. If those didn’t work, we have no choice but either live in some dystopian hellscape to save people from exactly one illness at the cost of literally all other issues… or we accept the risks and move on with our lives. 2 years of this is a non trivial amount of time.

We do have another choice, continuing to buy time to add to the arsenal of weapons we have against the virus. Things are only simple when you frame the issue simply; reality is complicated. You need only imagine yourself flickering out to see the value in doing what you can to keep someone from the same fate.

We are all alive in our heads just like you are in yours.

Re: New Concerning Variant: B.1.1.529

#256

> We know that B.1.1.529 is not a “Delta plus” variant. The figure below shows a really long line, with no previous Delta ancestors. So this likely means it mutated over time in one, likely immunocompromised, individual (see my P.S. note at the end of the post). How does that work ? Virus mutate inside the host until either death or the immune system stops it ? Why is the absence of selective pressure producing a vir…

Genome replication mistakes occur rarely but naturally. The covid virus has a proofreading enzyme, but it isn't foolproof. Selective pressure is selective, not creative.

With more complex organisms, its more, well, complex because they can do things like horizontal gene transfer. [EDIT]: But even here selective pressures just impose consequences, they don't cause HGT

Re: New Concerning Variant: B.1.1.529

#257
post #221

Earlier quoted context omitted.

And that's why I'm unironically for banning cars in the long term. They're a terrible mode of transport, trains and bikes are all we need.

Hmmm, I take it you live in a city? You may not need anything other than a train or bike but other people have different needs.

So I actually live in a small town of 800 people somewhere in Europe. I can take the train if i need to get anywhere further than is comfortable by bike.

I understand that's not currently the case in a lot of the world, which is why I think cars need to be banned eventually, not right now.

Re: New Concerning Variant: B.1.1.529

#258
post #100

Earlier quoted context omitted.

Masks are 100% effective at inconveniencing people’s lives and building a false sense of security.

I could say the same thing about pants but I still have to wear them in public.

You might be wearing pants wrong.

Re: New Concerning Variant: B.1.1.529

#260
post #248
post #170

Earlier quoted context omitted.

Mutations are happening in vaccinated people. It's similiar to what happens when you spray a new poison on an insect group. Most die but the bugs with mutations live replicate and quickly spread making that poison useless.

South Africa, where this strain originated, has a vaccination rate of 25%. Though I'm also curious why this only happens for this virus, and not any of the others we've destroyed with vaccination like smallpox, or reduced to nothingness like polio or measles. (short version: you don't know what you're talking about).

Mutations are happening in both populations. Specific mutation that make the vaccine ineffective are happening in vaccinated people.

This vaccine doesn't prevent covid the way the smallpox vaccine does. This is a new type of vaccine trying to reduce deaths. Calling the same is a marketing trick.

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