I swear I’ve read a hundred articles saying “here’s what we should’ve done to prevent this pandemic”. Let’s see if any lessons have been really learned; a new variant is practice for the next virus that comes on the scene. With the testing tech we have now, proper tracing, quarantines, and travel restrictions, could a variant be bottled up?
Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern
221–230 of 337 posts
Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern
#222Earlier quoted context omitted.
A study in Nature had previously shown that >= 20 amino acid mutations on the spike protein was sufficient to cause immune escape from the vaccine or previous infection, but that individuals who were both previously infected and vaccinated were still able to neutralize the mutant virus. [1] The omicron variant has >30 AA mutations on the spike protein, so it remains to be seen how effective vaccines are in response t…
> individuals who were both previously infected and vaccinated were still able to neutralize the mutant virus. Mainly because of the infection, not the vaccination. Infection trains your immune response to detect multiple factors of the virus, the mRNA vaccines are only for the spike protein which has considerable mutations in later variants like this one. Arguably, traditional dead-virus vaccines might provide bette…
That argument sounds good in theory, but we have data we can look at to assess — Sinovac is inactivated virus and it's efficacy was 50% against the early strains. Also, work has shown that spike antigen vaccines broaden the range of antibodies produced by previously infected immune system to increase neutralisation against later variants, even though the vaccines were of course based on ancestral spike protein sequence..
Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern
#223Earlier quoted context omitted.
Imagine being given almost 2 years to build capacity to put that fire out so the community could go back to normal life but instead zero additional capacity was built? Hospitals had almost 2 years to build capacity. Where is it? Why is society being asked to continue bailing out institutions that have had an enormous amount of time to prepare?
You just don't build capacity against something that grows exponentially until it hits a substantial part of the overall population. Say a country like the UK, at the peak of the curve, would have 1% of their population getting sick everyday for a week or two, and 1% of that getting in a hospital (very conservative since 1% is the IFR and lots of people get out of the hospital on their legs) You might have built the…
but then it didn't happen, did it? it never fucking happened, anywhere, lockdown or no. I remember a giant emergency field hospital that got built in the middle of london, and it sat there completely fucking bone idle. my initial numbers were wrong, and so were the experts'.
I remember a terrifyingly huge bell curve for hospitalizations assuming no lockdown, with a piddling little horizontal line just above the x-axis representing bed capacity. that apocalypse never happened for sweden or the numerous other places which never locked down. I remember watching the sweden case graph intently around May, smugly predicting a self-inflicted genocide. It never came. Then there was a US state (I forget which one) that ended its lockdown and opened up back to normal. I very confidently predicted a disaster that never arrived.
eventually (much later than I should have) I woke up from the mass hallucination. turns out covid, like other coronaviruses, is strongly seasonal, it waxes and wanes for reasons we don't quite understand. the exponential curve always burns itself out well short of what the hammer-and-dance people said, no matter what we do.
do you expect us to forget all that? do you really think we can be fooled twice? do you honestly think people will sit down and take another wave of lockdowns when we're in the middle of a supply chain and inflation crisis caused by the first one?
Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern
#224Twitter thread from a vaccine developer: https://threadreaderapp.com/thread/1464222680731820043.html A lot of speculation still, but it's not all bad so far.
His argument is fallacious. He's saying that since there all other variants we're susceptible to the vaccine, it's unlikely that this one is. ...and goes on to list the high number of different markers the vaccines target. Unfortunately, vaccines largely target the spike proteins, and sequencing of omicron is demonstrating that every single protein marker on the spike is changed. Vaccines will likely have a very smal…
Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern
#225Earlier quoted context omitted.
A heck of a lot of people really don't want to move on from all this. Life is way too short to be wasted living the way some of society seems to think is necessary "in order to take this serious". Disease and death have been a part of humanity since time began. All we can do is try to make the most out of the short time we have here on this earth. Playing this covid theater game for 2+ years is, in my opinion, an ins…
"some of you may have to die, but that is a sacrifice I'm willing to make"
(and really the piles won't be that high. they'll be of low-to-medium height, consisting mostly of the old and fat.)
Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern
#226Earlier quoted context omitted.
I know 5 people personally that have died of this virus, forgive me if I take offense at your hand waving of it
That doesn't mean any of these NPI's work, are ethical, or are worth their immense cost to society. It is entirely possible to "take this serious" but feel that society is causing itself far more harm with all these measures than it would have by doing absolutely nothing at all. None of these thing were in any playbook prior to march of 2020. And here we are almost a month from 2022 still working from this unwritten,…
Which things do you think are wild new tactics for trying to contain a pandemic? Social distancing? Lockdowns? Wearing masks in public? Because if you think any of those are untested wacky "nobody's ever tried anything like this before!" approaches, you need to spend a few more minutes with your favorite search engine.
Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern
#227Earlier quoted context omitted.
> individuals who were both previously infected and vaccinated were still able to neutralize the mutant virus. Mainly because of the infection, not the vaccination. Infection trains your immune response to detect multiple factors of the virus, the mRNA vaccines are only for the spike protein which has considerable mutations in later variants like this one. Arguably, traditional dead-virus vaccines might provide bette…
Somatic Hypermutation works on vaccine antigens as well, and diversifies B-cells so that the B-cells will recognize many spike mutations. Anyone who has been vaccinated or recovered probably has some B-cells which match this spike, even if they're not amplified and expressed into circulating neutralizing antibodies. T-cells on the other hand don't diversify as much but they recognize primarily the host MHC section of…
I don’t know why you bother explaining basic concepts when the other side is just looking for reasons to freak out.
Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern
#228Earlier quoted context omitted.
His argument is fallacious. He's saying that since there all other variants we're susceptible to the vaccine, it's unlikely that this one is. ...and goes on to list the high number of different markers the vaccines target. Unfortunately, vaccines largely target the spike proteins, and sequencing of omicron is demonstrating that every single protein marker on the spike is changed. Vaccines will likely have a very smal…
A study in Nature had previously shown that >= 20 amino acid mutations on the spike protein was sufficient to cause immune escape from the vaccine or previous infection, but that individuals who were both previously infected and vaccinated were still able to neutralize the mutant virus. [1] The omicron variant has >30 AA mutations on the spike protein, so it remains to be seen how effective vaccines are in response t…
It ignores any benefits that other vaccines or natural immunity might have compared to the mrna vaccines "spike-only" approach.
Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern
#229Earlier quoted context omitted.
“Mild” in this case means you don’t go to the hospital (and/or the morgue). It doesn’t rule out long COVID or extremely severe (from a layman’s perspective) symptoms. And that’s the same as other “mild” COVID infections, yep. The ones where you don’t die. You ignorant dipshit.
Well that last bit sure came out of left field.
Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern
#230My current take (not a virologist, doctor): At this point, if you are not immunocompromised and you have the first vaccination and a booster. You should be able to easily recover regardless of the mutation(s). The virus would need to completely diverge from SARS-CoV-2 in order to fully defeat the countermeasures of the current vaccinations.
> The virus would need to completely diverge from SARS-CoV-2 in order to fully defeat Yeah, you shouldnt be making these claims if you don't have specific background or understanding of what you are talking about All current vaccines target few/couple specific proteins and protein groups on the virus spikes which interact with our cells, if these couple spikes/protein groups change then the vaccines stop being effect…