201–210 of 337 posts
Earlier quoted context omitted.
Which is funny because I've heard that feature branching isn't the cool way to go about things now.
Covid uses trunk based development.
Earlier quoted context omitted.
A study in Nature had previously shown that >= 20 amino acid mutations on the spike protein was sufficient to cause immune escape from the vaccine or previous infection, but that individuals who were both previously infected and vaccinated were still able to neutralize the mutant virus. [1] The omicron variant has >30 AA mutations on the spike protein, so it remains to be seen how effective vaccines are in response t…
> individuals who were both previously infected and vaccinated were still able to neutralize the mutant virus. Mainly because of the infection, not the vaccination. Infection trains your immune response to detect multiple factors of the virus, the mRNA vaccines are only for the spike protein which has considerable mutations in later variants like this one. Arguably, traditional dead-virus vaccines might provide bette…
T-cells on the other hand don't diversify as much but they recognize primarily the host MHC section of the MHC-antigen complex, so they're already somewhat insensitive to mutations in the protein. The T-cells stimulated by vaccine or virus aren't special in that regard.
Arguably it doesn't really matter. If you get infected with this spike it is still going to have pretty much the same shape as the spike in the vaccine (after all even the mutated versions still need to bind to ACE2 and can't vary that broadly) and your vaccine-trained T-cells will still bind fine to the antigen-MHC complex that the spike forms.
There's this idea that antibodies and immune responses are like a key fitting perfectly into a lock where any pin being wrong doesn't unlock the lock, and that's just false. The immune system has a need to fuzzy match against antigens because it evolved against adversaries which mutate and attempt to reinfect.
You're pushing a narrative that spike-only vaccines are worse in the face of mutation, and there's just no evidence of that. On the other hand mRNA spike-only vaccines allow creating a very strong humoral response to the spike protein in the absence of significant side effects and their efficacy has been so far across the board superior to inactivated virus or viral-vector vaccines.
Earlier quoted context omitted.
You mean like we learned to live with the far more deadly (at least initially) influenza? As your body increasingly comes in contact with it you’ll build a solid immunity. Similar to the other mRNA viruses such as RSV (dangerous to babies, but almost no one else).
If Covid had occurred in 1918, it would likely have had a much higher CFR than H1N1 - no supplemental oxygen available at that time.
Earlier quoted context omitted.
Compassionate people should have a problem with being enslaved, mentally and physically, by a disease that, according to your stats has killed 0.06% of the world population - albeit, it's debatable how many people died as a direct result of it.
then you should also have problem with capitalism/plutocracy.
Earlier quoted context omitted.
> However, Dr Angelique Coetzee, chair of the South African Medical Association and a practising GP based in Pretoria, said it was “premature” to make predictions of a health crisis. “It’s all speculation at this stage. It may be it’s highly transmissible, but so far the cases we are seeing are extremely mild,” she said. “Maybe two weeks from now I will have a different opinion, but this is what we are seeing. So are…
"the cases we are seeing are extremely mild" So, like most COVID infections?
And that’s the same as other “mild” COVID infections, yep. The ones where you don’t die. You ignorant dipshit.
Will people ever get over sensationalism and learn to live with it? It will continue to mutate and spread for years to come. Putting life on pause should've never been an option because of the toxic precedent it created.
Imagine there was a fire near where you live, constantly spreading and endangering lives in your community. Would you say people can just "learn to live it"?
Obviously we would react differently to completely different things. What is even the point of this analogy?
Earlier quoted context omitted.
A heck of a lot of people really don't want to move on from all this. Life is way too short to be wasted living the way some of society seems to think is necessary "in order to take this serious". Disease and death have been a part of humanity since time began. All we can do is try to make the most out of the short time we have here on this earth. Playing this covid theater game for 2+ years is, in my opinion, an ins…
"some of you may have to die, but that is a sacrifice I'm willing to make"
Everyone behaves as if this is true every single day, regardless of how mad they get when it’s stated explicitly.
Earlier quoted context omitted.
Can you point to a single policy that has demonstrated (in an intellectually honest way) ANY efficacy in slowing covid? One?? Vax passports, cloth masks, N95 masks, face shields, closing schools, cohorts, WFH, clean/dirty pen jars (my fave), plexiglass, 6 feet, travel bans... The grim reality is that there hasn't been a single policy that's been shown to have made any difference at all. NONE. There's literally nothin…
>The grim reality is that there hasn't been a single policy that's been shown to have made any difference at all. NONE. BULLSHIT. How delusional can you be? There is plenty of evidence that masks and contact reduction in various forms have a massive effect on how quickly the virus spreads. Infection numbers and their development over time varied wildly between countries, clearly correlated with such measures, long be…
The comment you responded to asked for an honest, intellectual response but your response was reactionary, rude, and provided no insight.
The links you supplied in your other comment do not show a clear causal effect of mandates and restrictions on case rates. Outbreaks are known to follow a pretty clear 45 day cycle; the onset of restrictions usually occur as rates are exponentially increasing and theres no evidence that such restrictions taper infections to a degree discernible from the normal cycle.
Furthermore, observational evidence from states like Florida, a state that has zero restrictions or mandates and yet currently has the lowest case rate in the United States, make the idea that such measures have a “massive effect” on spread dubious at best.
Earlier quoted context omitted.
>vaccine developer >Chair of ...Maryland's Newest Anthropomorphic Convention! Not sure how I feel about this. Are many vaccine developers also furries?
There's an expose available on the pseudononymous author.[1] According to that, she is a Moderna employee. [1] https://www.inputmag.com/features/furry-scientist-vaccines-c...