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Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern

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Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern

#161

Post by Eliezer »

brandmeyer wrote: post #143
reindeer76 wrote: post #128

Earlier quoted context omitted.

Narrowness of immune response: >The mRNA and viral vector vaccines induced ONLY spike protein antibodies in the inoculated test subjects >In comparison, whole inactivated virus and natural infection induce antibodies to many parts of the virus Original antigenic sin: >Subjects injected with the old formulations have locked their immune response to only a few antibodies >Any new formulation of the injection will ampli…

Curious edit history. This pile of garbage originally used "vaxtard", "sin", and "purebloods". You really shouldn't take anything seriously from a source that uses those trigger phrases.

> Curious edit history. This pile of garbage originally used "vaxtard", "sin", and "purebloods". You really shouldn't take anything seriously from a source that uses those trigger phrases.

There's no edit histories on HN, unless I missed something.

Never forget the windowless buildings in Russia, where people are working to make you hate each other. At least make it harder for them than simple semiautomated tricks like this.

Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern

#162

Post by bmakdbd »

op00to wrote: post #88
sp332 wrote: post #71

Earlier quoted context omitted.

This does have quite a few mutations, including several that are pretty rare. https://github.com/cov-lineages/pango-designation/issues/343

Are people getting sicker with it?

> However, Dr Angelique Coetzee, chair of the South African Medical Association and a practising GP based in Pretoria, said it was “premature” to make predictions of a health crisis.

“It’s all speculation at this stage. It may be it’s highly transmissible, but so far the cases we are seeing are extremely mild,” she said. “Maybe two weeks from now I will have a different opinion, but this is what we are seeing. So are we seriously worried? No. We are concerned and we watch what’s happening. But for now we’re saying, ‘OK: there’s a whole hype out there. [We’re] not sure why.’”

https://www.theguardian.com/world/2021/nov/26/south-africa-b...

Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern

#163

Post by PicassoCTs »

jacquesm wrote: post #139
azeirah wrote: post #127

Earlier quoted context omitted.

I'd imagine many people in power have various hobbies you'd consider odd if you knew about them. (nevermind fetishes, oh my god!)

Never mind religion, oh your god!

Fetish, religion and bears, oh my!

Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern

#164

Post by [deleted] »

leegraham wrote: post #135
cblconfederate wrote: post #69

Earlier quoted context omitted.

I suppose Nu might be dangerously confusing with Mu , and Xi was politically untenable. The next one is going to be Pi

'Nu' also has the problem of sounding like 'new', so phrases like 'the Nu variant' are confusing if spoken aloud.

[deleted]

Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern

#165

Post by PicassoCTs »

mdni007 wrote: post #132
reindeer76 wrote: post #125

Earlier quoted context omitted.

>vaccine developer >Chair of ...Maryland's Newest Anthropomorphic Convention! Not sure how I feel about this. Are many vaccine developers also furries?

And he's a scientist but believes in horoscopes. I don't think I've seen someone living a more hypocritical lifestyle

https://webapp1.dlib.indiana.edu/newton/project/about.do

Its actually pretty common to venture outside the box in every regard, if you have the ability to venture outside the box.

Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern

#166

Post by fartattack »

koheripbal wrote: post #159
malepoon wrote: post #93

Twitter thread from a vaccine developer: https://threadreaderapp.com/thread/1464222680731820043.html A lot of speculation still, but it's not all bad so far.

His argument is fallacious. He's saying that since there all other variants we're susceptible to the vaccine, it's unlikely that this one is. ...and goes on to list the high number of different markers the vaccines target. Unfortunately, vaccines largely target the spike proteins, and sequencing of omicron is demonstrating that every single protein marker on the spike is changed. Vaccines will likely have a very smal…

Your argument is fallacious. You clearly lack even an elementary education in immunology. Exposure to the antigen teaches your immune memory cells what the antigen looks like.

Quit your job, stay home, live in fear. The rest of society doesn't need cowards like you.

The pandemic is over, except for paranoid people. There will be endless variants. It's an RNA virus. No amount of vaccination will be perfect, but life will go on.

Get vaccinated and go expose yourself to the existing endemic variants; it's the best defense there is.

Live your life. If you think you can wait until there are no more variants, you'll be locked inside wearing a mask forever. Some of us have lives to lead.

Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern

#167

Post by f38zf5vdt »

koheripbal wrote: post #159
malepoon wrote: post #93

Twitter thread from a vaccine developer: https://threadreaderapp.com/thread/1464222680731820043.html A lot of speculation still, but it's not all bad so far.

His argument is fallacious. He's saying that since there all other variants we're susceptible to the vaccine, it's unlikely that this one is. ...and goes on to list the high number of different markers the vaccines target. Unfortunately, vaccines largely target the spike proteins, and sequencing of omicron is demonstrating that every single protein marker on the spike is changed. Vaccines will likely have a very smal…

A study in Nature had previously shown that >= 20 amino acid mutations on the spike protein was sufficient to cause immune escape from the vaccine or previous infection, but that individuals who were both previously infected and vaccinated were still able to neutralize the mutant virus. [1]

The omicron variant has >30 AA mutations on the spike protein, so it remains to be seen how effective vaccines are in response to it. Even if it is unable to prevent infection, it's still likely that the vaccines will provide some attenuation of severity, especially with a booster. We also now have pharmaceutical means to treat infections, so any notions that this will bring us back to March 2020 seem unrealistic.

https://www.nature.com/articles/s41586-021-04005-0

Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern

#168

Post by tigershark »

nostromo wrote: post #121
malepoon wrote: post #93

Twitter thread from a vaccine developer: https://threadreaderapp.com/thread/1464222680731820043.html A lot of speculation still, but it's not all bad so far.

This image really puts it in context: https://images.app.goo.gl/13amCWF8aJ8q2eZAA The red portion of the graph on the far right is the new variant.

It started from an extremely low base. And extrapolating that curve is completely wrong as you can see from today numbers. 2.8k compared to yesterday 2.4K. It’s obviously still early to know anything conclusive but the relatively small increase today is a very good sign. We’ll know something more next week.

Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern

#169

Post by ASalazarMX »

PicassoCTs wrote: post #165
mdni007 wrote: post #132

Earlier quoted context omitted.

And he's a scientist but believes in horoscopes. I don't think I've seen someone living a more hypocritical lifestyle

https://webapp1.dlib.indiana.edu/newton/project/about.do Its actually pretty common to venture outside the box in every regard, if you have the ability to venture outside the box.

But horoscopes, my god. They're not outside the box, they're outside reality. It's like a physicist believing in perpetual motion.

Re: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern

#170

Post by Kye »

koheripbal wrote: post #159
malepoon wrote: post #93

Twitter thread from a vaccine developer: https://threadreaderapp.com/thread/1464222680731820043.html A lot of speculation still, but it's not all bad so far.

His argument is fallacious. He's saying that since there all other variants we're susceptible to the vaccine, it's unlikely that this one is. ...and goes on to list the high number of different markers the vaccines target. Unfortunately, vaccines largely target the spike proteins, and sequencing of omicron is demonstrating that every single protein marker on the spike is changed. Vaccines will likely have a very smal…

Chise is a she/her-shaped creature as far as I know.
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