Live data from Hacker News

Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

endpts.com

81–90 of 127 posts

Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

#81
Have a lot of experience with microdosing psilocybin, as well as with psychedelics like Ayahuasca. My experience with both as a means to remedy depression have been significant.

It is analagous to having a lamp in a dark forest. It won't get you through it itself, you need courage, and other tools like meditation (your machete), exercise (your provisions) and intention (your compass) to succeed. But with it, everything is easier.

Err -- AMA?

Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

#82
post #51

How does this get commercialized? I can't think of anything that's inherently cheap and easy to produce that you use for a few weeks and then never again that is also a financial cash cow the way most pharmaceuticals are. Disclaimer: I work for a pharma.

that's why i don't get all the psychedelic stocks and stuff i keep hearing about. seems like itll be less profitable than marijuana

Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

#83

The shrooms community has known about this for a long time, and now it's just about recreating the knowledge in peer-reviewed studies. Although there is a lot of "woo woo" on shrooms usage in the online communities, I do hope that researchers can extract the useful bits. This isn't like an SSRI. 25mg psilocybin isn't something you can just pop at the beginning of a workday. Your setting and "head space" matter a lot…

> This isn't like an SSRI. 25mg psilocybin isn't something you can just pop at the beginning of a workday. Your setting and "head space" matter a lot for how your "trip" (which we will now rebrand as "treatment") will go. This needs to be accounted for in future studies. This is what I worry about. It's likely great, when done in the care of a licensed and trained therapist . It's not the mystical panacea many will m…

From personal experience treating mental issues with psilocybin, this isn't a dose you need to do frequently. Think 1/year.

Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

#84

Have a lot of experience with microdosing psilocybin, as well as with psychedelics like Ayahuasca. My experience with both as a means to remedy depression have been significant. It is analagous to having a lamp in a dark forest. It won't get you through it itself, you need courage, and other tools like meditation (your machete), exercise (your provisions) and intention (your compass) to succeed. But with it, everythi…

With micro-dosing, doesn't your body get acclimated to the low doses taken over extended periods of time and thus rendering the micro-dose ineffective? I assume you have to cycle with it?

Are there any negative effects on your off-cycle days? i.e less creativity or feeling down

Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

#85

Have a lot of experience with microdosing psilocybin, as well as with psychedelics like Ayahuasca. My experience with both as a means to remedy depression have been significant. It is analagous to having a lamp in a dark forest. It won't get you through it itself, you need courage, and other tools like meditation (your machete), exercise (your provisions) and intention (your compass) to succeed. But with it, everythi…

Interesting analogy of a dark forest. I'd say the Zen realization is of value here. You can always, at any moment, realize that your sensations and consciousness is all there is. We don't need anything more than to observe what we sense at any moment. I say this because changing our mind doesn't have to be hard arduous work, Zen Buddhists realized that enlightenment is here now, if we have the will to simply see it and accept it.

Regarding machetes, wow. I'd say meditation is more like the calm and the observation of the dark forest, not a machete. A machete is a constant necessity to hack through tough issues. Meditation is the art of doing nothing, of simply noticing what is occurring. In that way, it's more like standing still and observing the jungle, not hacking it.

I like Sam Harris's analogy best. Meditation is taking a calm sail boat ride to wisdom, whereas psychedelics are like being strapped to a rocket. Both will get you places, but one is more likely to crash.

Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

#86

The shrooms community has known about this for a long time, and now it's just about recreating the knowledge in peer-reviewed studies. Although there is a lot of "woo woo" on shrooms usage in the online communities, I do hope that researchers can extract the useful bits. This isn't like an SSRI. 25mg psilocybin isn't something you can just pop at the beginning of a workday. Your setting and "head space" matter a lot…

> 25mg psilocybin isn't something you can just pop at the beginning of a workday. I would disagree. For many, 25mg is sub-perceptual. Source: have done this over several year.

3-5 grams of mushrooms?

I want to work where you work. I hope it doesn't involve heavy machinery.

Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

#87

Have a lot of experience with microdosing psilocybin, as well as with psychedelics like Ayahuasca. My experience with both as a means to remedy depression have been significant. It is analagous to having a lamp in a dark forest. It won't get you through it itself, you need courage, and other tools like meditation (your machete), exercise (your provisions) and intention (your compass) to succeed. But with it, everythi…

This is something I've been interested in for a good while now, and tried a similar LSD microdosing regimen without any exciting results. However, I also didn't pair the practice with meditation or regular exercise (some, not a lot).

My main question is, how does one get anything like a regular, precise (micro)dose of the psilocybin? Volumetric dilution with LSD seems simple, because I know how much each tab contains and can plan accordingly. Are mushrooms really that regular in compound content?

Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

#88

Have a lot of experience with microdosing psilocybin, as well as with psychedelics like Ayahuasca. My experience with both as a means to remedy depression have been significant. It is analagous to having a lamp in a dark forest. It won't get you through it itself, you need courage, and other tools like meditation (your machete), exercise (your provisions) and intention (your compass) to succeed. But with it, everythi…

[deleted]

Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

#89
post #67

As somebody who sometimes "treats" severe multi-decades-long depression with psychedelics, I'm not surprised that they'd have a positive impact but the news seems too unclear to my simple mind to make sense of a few things: 1- why is a private group on the stock market doing this, instead of public research & universities? vested interests in seizing a market of illegal drugs in a legal way worry me, because it's eas…

I too have treated MDD with psychedelics along side CBT therapy (not in official conjunction) and found that my suicidal ideation and anhedonia subsided for about a year after my first big trip. Since then, I've done heroic doses and microdoses and found that the most beneficial to me was infrequent large doses combined with integration in therapy afterwards. I agree with your take that it's more akin to a "shock therapy" than a regular medication.

I'm curious, do you work with a talk therapist? If so, do you feel like the therapy + psychedelics is better than either alone?

Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms

#90

The shrooms community has known about this for a long time, and now it's just about recreating the knowledge in peer-reviewed studies. Although there is a lot of "woo woo" on shrooms usage in the online communities, I do hope that researchers can extract the useful bits. This isn't like an SSRI. 25mg psilocybin isn't something you can just pop at the beginning of a workday. Your setting and "head space" matter a lot…

> 25mg psilocybin isn't something you can just pop at the beginning of a workday. I would disagree. For many, 25mg is sub-perceptual. Source: have done this over several year.

20-something mg of 4aco dmt was pretty wild, psilocybin must be somewhat similar
Post reply on HN