How does this get commercialized? I can't think of anything that's inherently cheap and easy to produce that you use for a few weeks and then never again that is also a financial cash cow the way most pharmaceuticals are. Disclaimer: I work for a pharma.
Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
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Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#5229.1% effective Headline could be more informative by including this number.
So more effective than antidepressants?
Great news!
Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#53How does this get commercialized? I can't think of anything that's inherently cheap and easy to produce that you use for a few weeks and then never again that is also a financial cash cow the way most pharmaceuticals are. Disclaimer: I work for a pharma.
They figured out how to jack up the price of ketamine 100x by making it esketamine - find an analog, shove in an acetyl group somewhere, something something chiral something
Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#54How does this get commercialized? I can't think of anything that's inherently cheap and easy to produce that you use for a few weeks and then never again that is also a financial cash cow the way most pharmaceuticals are. Disclaimer: I work for a pharma.
The money is in the professional therapists who administer this. It's the same model that's currently working for Ketamine.
Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#5529.1% effective Headline could be more informative by including this number.
So more effective than antidepressants? Great news!
Do you have a source? I don't think it is "more effective" in terms of the remission rate. That being said, in this hypothetical world where you can choose between shrooms and SSRIs, you would have to compare the side effects as well.
Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#5629.1% effective Headline could be more informative by including this number.
That number is misleading without context for how effective other drugs are and in comparison to placebo. Given that placebo was ~8% effective this is a highly promising treatment.
I think that was the control group, not placebo. But I didn't read the study in depth.
Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#5729.1% effective Headline could be more informative by including this number.
With the placebo group too "Overall, 29.1% of patients in the highest-dose group were in remission three weeks after treatment, compared to 7.6% of those in the control group, "
In remission after three weeks is pretty impressive, too. There's many antidepressants which take a lot longer to ramp up to being effective, even assuming they work for you.
Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#58This 29.1% effectiveness is awesome considering it is a single dose that was given.
Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#59There was a great interview between Peter Attia and David Nutt on the research and effectiveness of psychedelics on various disorders https://peterattiamd.com/davidnutt/
He touches on the history of governments banning various drugs through junk science and propaganda (mostly from the US which influences the rest of the world). The scheduling system for drugs is a joke.
Also interesting that the inventor of AA credited LSD for his ability to quit drinking.
Edit: David Nutt authored this study in the NEJM https://www.nejm.org/doi/full/10.1056/nejmoa2032994 which pitted psilocybin against lexapro for the treatment of depression and it showed the same effectiveness (more nuanced than that but you'll have to read or listen). Peter talked about how he is very familiar with Lexapro and it's side effects (libido, a blunting effect on life) in his patients and remarked that what was most exciting about that study is that it showed it could be as effective as Lexapro with less side effects.
Re: Compass Pathways' Phase IIb psilocybin trial shows reduced depression symptoms
#60The shrooms community has known about this for a long time, and now it's just about recreating the knowledge in peer-reviewed studies. Although there is a lot of "woo woo" on shrooms usage in the online communities, I do hope that researchers can extract the useful bits.
This isn't like an SSRI. 25mg psilocybin isn't something you can just pop at the beginning of a workday. Your setting and "head space" matter a lot for how your "trip" (which we will now rebrand as "treatment") will go. This needs to be accounted for in future studies.