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Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

fiercebiotech.com

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Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#951

Post by swader999 »

ceejayoz wrote: post #895
swader999 wrote: post #881

Earlier quoted context omitted.

Well it felt like I never really got over it. Aside from a brief period of fever, everything else stayed until ivermectin. Headache, fatigue, sob, cough, sense of smell issues, brain fog, all kinds of erratic heart problems. There's a lot of speculation that long covid results from the virus migrating into the body and organs where it persists. This makes sense with what I experienced. Symptoms I've never had before…

How would you determine if it was the ivermectin, coincidence, or the placebo effect? (That's what the studies are for, and thus far, they've shown little sign of the effect you describe on statistically significant populations.)

It was three months of hoping it would get better with no movement. Then five hours later I could breathe again. So physical stuff happened. I get that placebo effect can do this but still. Coincidence would be rare and I don't think long covid resolves that way, been told it is more gradual. I've heard a lot of similar reports on a covid telegram channel I'm on, same with reddit before it got overrun with trolls. You can tell genuine discourse, especially when its the same people over several days going through the same experience.

None of this is scientific. What was is the safety on it so that made it low risk to try.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#952

Post by swader999 »

okaram wrote: post #944
swader999 wrote: post #823

Earlier quoted context omitted.

I had one vaccine dose with severe issues. So maybe I'm skeptical, I won't get a second or third dose. Most people in this camp will just use ivermectin. Including myself, it works and is safe.

There is no evidence ivermectin works against COVID. There is still one large study running, I think, that might show a small effect, but definitely not a big effect. Sorry you had a severe issue with your vaccine.

That larger study is only doing three days of doses which unfortunately isn't enough in most cases.

I had a hardened blood clot surgically removed off my scalp the other day. Was in a vein right by my temple. When the report comes back confirming I'm hoping it'll get me a proper scan.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#953

Post by Auracle »

adrr wrote: post #914
refurb wrote: post #886

Earlier quoted context omitted.

Terrible take. Your first source vaguely tries to estimate promotional spending (not advertising as you deceitfully claim). Promotional spend has a positive ROI (or you wouldn’t do it). So spending $1B in promotion gets your $1B+ in sales (it’s self funding). Plus stock buybacks and dividends are being criticized? Returning money to investors is “bad”? Who do you think provides capital for drug development? The Grena…

But does it really increase sales? We’re talking drugs that are prescribed by a doctor. Or do people not buy and take their statins unless they see a tv ad?

I mean, cancer drugs are regularly advertised.

That should scare everyone and I’m not sure why it doesn’t. They wouldn’t be advertising them if it didn’t increase sales, which probably means oncologists aren’t always prescribing what’s best.

As far as other medications, most people don’t go to the doctor regularly. Even if they did, they would probably need to inquire about their condition to have the doctor think of updating anything.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#954

Post by otabdeveloper4 »

adventured wrote: post #114
widjit wrote: post #59

Earlier quoted context omitted.

as someone who definitely had and suffered through long COVID, I would like to know what you think you are accomplishing by making false claims like this. do you think you're being edgy? what possible work is your ignorant comment doing?

It took me about six months to recover from Covid post infection. I got it in the early weeks of the pandemic; it took from around mid April to October of 2020 to get back to normal. I've felt fine since. I don't know what exactly they're calling long Covid these days, but the parent comment is pretty obviously ignorant.

Like the other guy said, "long everything" exists, and so-called "long Covid" isn't any different than long complications from garden-variety colds and flus.

Attributing special powers specifically to Covid is just attention-seeking behavior.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#955

Post by topoftheforts »

whateveracct wrote: post #929
TacticalCoder wrote: post #583

So no we have the Pfizer vaccine (which I got) who cuts the risk of both catching the virus and the risk of severe complication by a lot (forgot the number but it's big) and in addition to that we now have Pfizer oral medication that can be given to positive cases and which reduces both hospitalization and death risk by 85%. When can life go back to normal?

What's so different now exactly? I can go to restaurants, the store, the movies, fly. I gotta wear a mask indoors to some degree, so I guess we're at like 99% normal.

Have you tried travelling abroad? It’s still much more complicated than it was, you have to check both countries requirements, spend money on tests, fill additional forms

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#957

Post by orra »

jiggawatts wrote: post #913
orra wrote: post #144

I am thinking: if and when this is approved, we have to think about distribution. This drug is fantastically effective at preventing hospitalisation and death, if administered within three days of symptom onset. That gives quite a long time! But we still need to make it easy to take. Do pharmacies give it out? ER rooms? We don't want to wait until people are hospitalised; we are trying to avoid that. So when you test…

COVID-19 is not the only coronavirus! If this drug is safe and can be made sufficiently cheap, it could be a great treatment for most kinds of common cold. Why suffer for weeks with cold symptoms if you can simply spray this up your nose and feel better? It could (potentially) be used similarly to Tamiflu.

Alas you are a tad optimistic.

The majority of the common cold cases is caused by rhinoviruses. But yes, like 20% (ballpark) are caused by coronaviruses.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#958

Post by orra »

tsol wrote: post #844
rajup wrote: post #839

Earlier quoted context omitted.

> My fear is that a lot of people won't bother with a vax if they think there's a 'cure'. Interesting. Indeed, should people bother with a vax if there's a highly effective cure? Is it worth all the teeth-gnashing and hair pulling on the part of the medical establishment, political establishment and media about people who would rather get COVID than get the vaccine? IMO this cure (once it starts rolling out ofc) is a…

Then you have the issue of people continuing to spread it to those who can't take a vaccine, including the immunocompromised. There is also the worry of the effects of long covid. Just yesterday I was reading a thread on here of people complaining about experiences of their loved ones with long term covid after effects not being able to find relief from doctors because, well, we still don't even know what causes it.…

> spread it to those who can't take a vaccine, including the immunocompromised.

I agree we should get vaccinated to reduce spread but, good news, this is wrong. UK clinical guidelines[1] state the immunocompromised and the immunosuppressed should get vaccinated.

In fact, they basically recommend everybody be vaccinated. Pregnant? Yes. Mild allergies? Yes. History of anaphylaxis caused by a specific ingredient in the vaccine? Speak to a a specialist who should offer (where possible) an alternative vaccine.

Moreover we know two doses of the vaccines produce an antibody response in the immunosuppressed.

That said, three doses is a good idea[2] to boost that response to a more typical level.

[1] https://www.gov.uk/government/publications/covid-19-the-gree...

[2] https://twitter.com/sailorrooscout/status/138026987700974387... and preceding thread

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#959

Post by ralmeida »

nradov wrote: post #848
ralmeida wrote: post #117

Earlier quoted context omitted.

> it does little to prevent spread How much, exactly? > Over the long run we'll all be exposed no matter what we do Plausible, but your sources don't appear to support that, other than the claim from Mr. Pollard. Is there anything I'm missing?

“The most statistically significant data point is that vaccinated people certainly have a faster rate of viral decline,” said Ferguson, “so they may potentially be infectious for less time, but they don’t necessarily have any reduced peak of viral load. Most transmission probably happens around that peak of viral load, which is why we think we’re still seeing substantial transmission rates from vaccinated people, bot…

And yet your own linked study says, right in the first paragraph, that vaccinated contacts got it 38% less often.

Is it possible that this is not enough, and “virtually everyone will eventually be exposed”? Yes. Is it possible that COVID will become endemic and many (but not all or even most) people will be exposed? Yes. Have I seen any source that makes a strong case for this? Not yet.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#960

Post by ralmeida »

FjolsvithAase wrote: post #916
ralmeida wrote: post #98

Earlier quoted context omitted.

Do you have a source for R0 being _absolutely equal_ in vaccinated vs unvaccinated?

Give them time.

Time can also yield better vaccines, a policy of recurring vaccine doses (like the yearly flu shots), and milder variants that can emerge and become dominant, like some believe is what happened with the Spanish Flu.
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