801–810 of 1001 posts
> compared to 41 hospitalizations and 10 deaths in the placebo cohort This makes me weirdly sad. Can you imagine entering the trial for a long sought drug against a deadly disease that turn out to be working, and end up in the control group? I know that there's more to it (it's necessary, they knew, it could have not worked, plainly be nocive, etc.) but it's like being unlucky twice in a row and die out of that while…
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Operation Warp Speed is, to me, an indication of the power of government "intertia". Trump changed a lot of things, and while an uncomfortable amount of the U.S. government seems to run on "tradition" that isn't actually law, after 4 years of unchecked assault it was only at the very end that it really got crazy. Warp speed is the work of career guys. Not even Fauchi -- he was important, but these ideas are put toget…
> Operation Warp Speed is, to me, an indication of the power of government "intertia". We call this the Deep State
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> The mRNA vaccines do not, and never have, reduce the spread of the virus from one infected person to someone else That's simply not correct.
Do you have a source for that? "fully vaccinated individuals with breakthrough infections have peak viral load similar to unvaccinated cases and can efficiently transmit infection in household settings, including to fully vaccinated contacts." [1] [1] https://www.thelancet.com/journals/laninf/article/PIIS1473-3...
Vaccinated people are less likely to be infected, hence "breakthrough case." Your quote is like saying that "people thrown out of windows in car crashes have the same rate of injury, despite whether the person was wearing a seatbelt or not." That may be true, but wearing a seatbelt definitely reduces the chance of getting thrown out of a window.
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It's funny that people read the same data with such different interpretations. This is why I feel like the insistence of "just look at the data" rarely leads to a clear decision, and anyone working at a company that has dealt with giving data to people to make decisions will know this intimately. People use data to make their point, and if the data doesn't agree, then they slice it or adjust it or reason their way ou…
There are several problems, but a big one is just the way the news works. ICUs are designed to run at near capacity and are overwhelmed all the time if, for example, there's a big car accident. Right now, all eyes are on the pandemic and I'm sure it's true that there's places in the country where ICUs are full up with pandemic patients. But the way the news cycle works, "ICUs at capacity with COVID patients" gets a l…
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I think skepticism of vaccines largely doesn't transfer to the broader medical field. The ineffective fad treatments (ivermectin and hydroxychloroquine) are still medicine, but are still "popular" with vaccine skeptics. It's not rational, but I think vaccine skepticism is largely not rational to begin with.
Anecdotally, hearing from doctors working in COVID wards, they consist almost entirely of anti-vaxxers who are now seeking (and receiving) treatments only recently approved. So while not everyone will take this, I think probably many would once they have symptoms. That said, this does work better it seems if taken early, before the anti-vax sentiment may have worn off. Hard to say. What it does signal is really the "…
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This already went through Phase III trials. It's closer in analogy to having the entire QA team on standby at their desks to do a full test as soon as you submit a PR at 1:38am for a feature that has to go live ASAP.
Lol did you not see the revelations about what was going on inside of Ventavia, the contractor that did the trial research for pfizer? They broke all sorts of protocols, covered it up, had it reported to the FDA, who in turn just sat on it.
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Operation Warp Speed is, to me, an indication of the power of government "intertia". Trump changed a lot of things, and while an uncomfortable amount of the U.S. government seems to run on "tradition" that isn't actually law, after 4 years of unchecked assault it was only at the very end that it really got crazy. Warp speed is the work of career guys. Not even Fauchi -- he was important, but these ideas are put toget…
> Operation Warp Speed is, to me, an indication of the power of government "intertia". We call this the Deep State
The truth is that any government needs a ton of people to operate properly and you can't change all of them upon election.
Actually, scratch that, you can sort of do that every election/change of government.
Do you know where they do that? Failed states. Failed states change most if not all the government employees upon regime change, to put people from the new regime in their place.
It's an unmitigated disaster, because you also need people other than politicians to do the heavy lifting. And those skills can't always be built up over just 4 years, you need more than that. It's dumb to throw them away. Let alone the fact that changing them with the regime means that it's super unlikely you keep the competent people, you just get new loyal folks.
> Pfizer’s phase 2/3 trial randomized non-hospitalized adult COVID-19 patients who were at high risk of progressing to severe illness to receive placebo or Paxlovid, a combination of the protease inhibitors PF-07321332 and ritonavir. The efficacy analysis is based on 1,219 patients. One noteworthy feature is the newness of this drug: > PF-07321332 was developed from scratch during the current pandemic. It’s a reversi…
Wars and pandemics seem to be the testbeds for medicine, where people are desperate enough to try anything, and legislation is relaxed accordingly. The biotech companies know this all too well, and take advantage when the opportunity arises.