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Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

fiercebiotech.com

621–630 of 1001 posts

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#621
> As a protease inhibitor, Paxlovid is free from the theoretical DNA-alteration risk tied to the mechanism of action of Merck’s molnupiravir.

This is the line I was looking for. Not that I know how protease inhibitor works, but looks more like a traditional anti-viral approach v.s. the potentially DNA altering molnupiravir.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#622
post #455

Earlier quoted context omitted.

This is a good article. I'm firmly on team do-what-it-takes-to-stop-the-spread, but no one has an exit strategy. I got a booster and we have appointments for two of our three kids to get there first shot. By mid-December I'm hoping to not have to think much about it anymore. https://www.theatlantic.com/health/archive/2021/11/what-amer...

I encourage everyone eligible to get vaccinated, but at this point there is zero possibility to stop the spread. Your "team" never had a chance. We can all expect to get infected eventually. https://www.nature.com/articles/d41586-021-02689-y https://www.businessinsider.com/delta-variant-made-herd-immu...

By "stop", I guess I really mean slow/reduce/flatten-the-curve, etc. It's all a game of probabilities, and I guess I'm on team lets-work-together-as-a-society-to-reduce-the-chances-of-getting-and-spreading-sars-cov2. But that's slightly less catchy.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#623

Earlier quoted context omitted.

Soo, kinda like for a vaccine? (And to clarify what I am saying, even though the vaccine does prevent death, there is still considerable push back. Not sure why it will be different for this drug)

Away from the debate about who will or won't take the vaccines and why, isn't this is a huge positive for the small (but not tiny) number of people for whom vaccines don't provoke immune response (severely immunocompromised, etc)? That group are also more vulnerable to bad outcomes from Covid.

That's one of my hopes. I don't know if this would have an adverse reaction for immunocompromised patients, but if not that would be fantastic.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#624
post #385

Earlier quoted context omitted.

It’s pretty amazing how stupid and shortsighted people are. We’re so good at overlooking the horrible situation we’re in and focusing on other things that are completely irrelevant I used to think that one of the worst things in the USA was that 100 people per day die in preventable car accidents, but now we’re getting 10x that from a virus and people pretend that it isn’t happening

The last two years have convinced me: When the Zombie Apocalypse comes, zombies are biting and killing people in the streets, and neighborhoods are burning down, 50% of the country (world?) will whistle and just continue to go about their day, shopping, going out to eat, sending their kids to school, and looking down at all those hysterical alarmists bunkering up trying to defend themselves from the hoard. "Governmen…

That's the beautiful part of humans, though, we push through and live our lives no matter what. If everyone panicked every time there was something that seemed apocalypse, then we probably wouldn't be where we are today. Maybe it's just the resilient ones that survive and keep reproducing.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#625
post #296

Earlier quoted context omitted.

I've always found it strange that some Americans focus on politeness above all. Of all the problems in your story, the employee shouting is the least 'wrong'. You've got a woman who won't wear a mask, yourself who sneaked in without a mask, and that's just in that moment of time, but somehow the employee who has to deal with that behavior all day every day is the bad person because they lost their cool. It's one of t…

He’s vaccinated, so it seems a little dramatic to be calling OP a bad person and that they suck.

Vaccinated people still spread the covid and vaccinated people still get covid. Most of my friend group was infected when two vaccinated friends came up to visit. They said they were feeling sick but because they were vaccinated it was fine. I think everyone in the group but 1 person was vaccinated.

The idea that once you are vaccinated you don't need to social distance or wear a mask is wrong and is getting people sick. In fact a vaccinated infection appears to have the same viral load as an unvaccinated. https://www.ucdavis.edu/health/covid-19/news/viral-loads-sim...

If I'm out in public, I wear socks everyday (well most), I wear a shirt, I wear pants. Its not much of a stretch to wear a mask out in public too.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#626

Does anyone have a sense as to when US society will completely eliminate COVID measures? Is it just me or is there no clear exit criteria anymore? This will go on forever without exit criteria.

I don't know but I haven't had a cold or any other infection in 18 months so I hope that wearing masks on trains, planes and buses stays forever. Also, shaking hands was always barbaric and I don't miss that, either.

People are really confusing the effects of "wearing a mask on the bus" with the effects of "closing offices and schools down."

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#627
post #296

Earlier quoted context omitted.

He’s vaccinated, so it seems a little dramatic to be calling OP a bad person and that they suck.

The vaccine protects you but still allows you to carry and spread a viral load. The mask protects people around you but not yourself but limiting the viral load that you can spread. By being a vaccinated unmasked person in a crowd of non-vaccinated people, you possibly become a super spreader.

The vaccine drastically reduces your chance to spread the virus.

https://www.medrxiv.org/content/10.1101/2021.07.13.21260393v...

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#628

Earlier quoted context omitted.

Incorrect, mRNA COVID vaccination is about reducing symptoms in infected patients. It does absolutely nothing to slow down or stop the spread of COVID.

This is one of the most persistent pieces of misinformation I've seen, especially in the face of clear data. The reduction in transmission rate for the vaccinated is 89%. Even for someone with a breakthrough infection of the more contagious Delta variant being vaccinated means a 63% reduction. https://www.newscientist.com/article/2294250-how-much-less-l...

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Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#629

Earlier quoted context omitted.

Prions are "just" proteins that should get broken down by the body. But they don't, and they cause ‎Creutzfeldt-Jakob in over 10 years after ingesting.

It's a good thing we're all here on HN to question the safety of novel pharmaceuticals. If we weren't, maybe nobody would, and we'd all just be putting prions into ourselves. If you have something specific about this particular molecule to talk about vis a vis safety, that's an interesting comment to make. But "aspirin is a molecule but so is Mad Cow Disease so we had better be careful about new drugs" is just about…

Derek Lowe is the biggest pharma shill in media.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#630
post #406

Earlier quoted context omitted.

VAERS is a great thing, but it's deeply unfortunate that antivax conspiracy theorists have used it to spread lies like yours. https://www.science.org/content/article/antivaccine-activist...

There is no conspiracy theory here. Stop using that term to minimize the importance of things. VAERS is a data point. Check out similar data points from other countries. Numbers DO match.

What other data points? Can you provide peer reviewed high quality data to support your claims? Just because you want a conspiracy theory to be true does not make it so.
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