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Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

fiercebiotech.com

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Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#561

Post by subsubzero »

pie42000 wrote: post #491
thehappypm wrote: post #390

It’s crazy that money is such a huge incentive. Knowing that a cure for Covid is a potentially $100B market means you throw the kitchen sink at it. Imagine being this lab. Do you think they ever had trouble hiring an assistant? Buying new equipment? Getting bonuses? This environment must be fantastically different from the typical meat grinder of bio R&D.

This is what being an engineer during WW2 must have been like. Near infinite money and resources, but very tough deadlines

agree, The manhattan project alone was 1% of the US GDP during its most expensive year, that would equate to $230 Billion in today's dollars.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#562

Post by randcraw »

yosito wrote: post #207
roenxi wrote: post #86

> This is a completely novel molecule... Then do we understand the risk profile of this thing? That sounds like the sort of innovation that people would want to be at the back of the queue for. Side effects don't have to happen in the next 6 months.

> Side effects don't have to happen in the next 6 months. If this is a molecule with a short half-life that is broken down and expelled by the body, it isn't going to have random side effects that show up months in the future.

And you're going to take the drug for only about 7-10 days. It's unlikely that such a short exposure will introduce lasting toxicity.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#563

Post by peeters »

wincy wrote: post #169
colordrops wrote: post #110

Does anyone have a sense as to when US society will completely eliminate COVID measures? Is it just me or is there no clear exit criteria anymore? This will go on forever without exit criteria.

I live in Kansas and have basically forgotten COVID is a thing. The people who wanted to get vaccinated like me have and those who haven’t, haven’t. Nobody asks about it and no businesses have any sort of mask requirements. Half of the people at the grocery store wear masks and the other half don’t. Everyone seems to be getting along. Next door in Kansas City Missouri I stopped at a gas station and an employee was sh…

> I guess 5 miles difference magically makes COVID much more contagious.

Well, based on case and death counts between the two states, this is true. Kansas has significantly higher case and death rates than Missouri.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#564

Post by cinntaile »

xattt wrote: post #551
Robotbeat wrote: post #536

Earlier quoted context omitted.

Well hopefully money serves as a tool for prioritizing resources for important problems. Seems to be working well in this case.

The added incentive is survival of the species.

Lets not overdo it. Covid is not wiping out the human species.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#565

Post by ricardobayes »

pezzana wrote: post #349

> Pfizer’s phase 2/3 trial randomized non-hospitalized adult COVID-19 patients who were at high risk of progressing to severe illness to receive placebo or Paxlovid, a combination of the protease inhibitors PF-07321332 and ritonavir. The efficacy analysis is based on 1,219 patients. One noteworthy feature is the newness of this drug: > PF-07321332 was developed from scratch during the current pandemic. It’s a reversi…

Is anyone familiar how this scaling up process works? To what point can it be scaled up using lab methods, and at which point does it make sense to start making it large-scale?

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#566

Post by ddingus »

aj7 wrote: post #285
matsemann wrote: post #178

Earlier quoted context omitted.

It seems to me that you're one of those not understanding COVID death rates, though. Firstly, even though I doubt your number a bit, even a 1/200 chance of death is mighty high enough for most people to seek treatment for something. Secondly, if you're already infected, the pill is probably less risky than those 1/200. Thirdly, the chance of death isn't equal for everyone. A healthy young person might have a 10x redu…

A 1/200 chance of death is gigantic.

Right!

It floors me to see so many not internalizing what that means.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#567

Post by therealdrag0 »

xattt wrote: post #551
Robotbeat wrote: post #536

Earlier quoted context omitted.

Well hopefully money serves as a tool for prioritizing resources for important problems. Seems to be working well in this case.

The added incentive is survival of the species.

How is species survival at risk?

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#568

Post by vibrato2 »

thedorkknight wrote: post #355
kibwen wrote: post #79

Earlier quoted context omitted.

'There is no relationship at all between the two drugs, said Dr. William A Petri, professor of infectious diseases at the University of Virginia. “The only way they are alike is that they are both pills,” Petri said. Dr. Kevin J. Downes, assistant professor of pediatrics at the Perelman School of Medicine of the University of Pennsylvania, agreed, “They are dramatically different molecules. The drugs are different in…

To the user who keeps getting comments deleted for bringing up this guy's funding: please look up "ad hominem fallacy". Attacking someone making a statement says nothing about the truth of their statement

What attack? He stated a fact about this mans funding relationship to Pfizer. He didn’t say anything about his trustworthiness, you assumed such.

It’s not an ad hominem if it’s something the reader assumes. It is a relevant detail to consider whether to trust the person’s statement. He didn’t say the guy was a shill or to never trust a funded scientist.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#569

Post by rpmisms »

jlongr wrote: post #515
salemh wrote: post #352

Earlier quoted context omitted.

Your children do not need it - perhaps you should evaluate whether they are in an 'at risk' category like the Nordics https://www.nature.com/articles/d41586-021-01897-w In the US, 340 children under 17 have died from Covid. Total. During the same period, 187 have died from the flu, and over 51,000 children have died from all causes: https://www.cdc.gov/nchs/nvss/vsrr/covid_weekly/index.htm#Se... Sweden halts Moderna:…

From the nature.com link that you posted: “The low rate of severe acute disease is important news, but this does not have to mean that COVID does not matter to children,” says paediatrician Danilo Buonsenso at the Gemelli University Hospital in Rome. “Please, let’s keep attention — as much as is feasible — on immunization.”

How about 1 out of 52 children in the 5-11 test group experiencing heart inflammation as a result of the vaccine? That sounds a hell of a lot more dangerous than covid for kids.

> "according to data reviewed by the CDC's advisory panel on vaccines, as of Oct. 10, almost 2 million 5- to 11-year-olds have gotten ill from COVID-19, and 94 have died."

That's a laughably low death rate. Driving your child to school is more dangerous for them than Covid.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#570

Post by ddingus »

sgtnoodle wrote: post #493
rndgermandude wrote: post #252

Earlier quoted context omitted.

If you die of Covid, your loved ones will not care if the chance of that happening was low. You won't care either, you'll be dead. All it really takes is that one previously-undiagnosed comorbidity to put you in the front of a the line for a casket-fitting even if you're young(-ish). If you survive but get permanent damage e.g. due to the blood clots that a lot of COVID patients develop, or due to the side effects of…

My teenage athlete nephew mysteriously developed heart problems right around after he got vaccinated, and now he can barely walk up a flight of stairs. No one is going to say the vaccine caused it, but the timing seems pretty damning. Meanwhile, if you look at the CDC stats, the risk of injury from covid for his demographic is at least an order of magnitude lower than his risk from riding in a car. Personally I don't…

Perhaps he got the vaccine in the bloodstream as opposed to muscle tissue as intended.

There are reports now of injections done without pulling back to see whether the injection site is a blood vessel. How the drug performs is seriously different in blood stream vs muscle tissue.

The primary impact of blood stream doses appears to be heart related problems.

https://pubmed.ncbi.nlm.nih.gov/34406358/

TL;DR: The vaccine probably did not cause it. How it was administered could be the cause.

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