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Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

fiercebiotech.com

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Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#501

Does anyone have a sense as to when US society will completely eliminate COVID measures? Is it just me or is there no clear exit criteria anymore? This will go on forever without exit criteria.

For me, it's when the kids get vaccinated.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#502
post #398

Earlier quoted context omitted.

Yes, the US populace has elected to fund a public health organization which has advised on public health measures since its inception (which is not recent or coincident with Covid-19). You are not forced to take any vaccine, though many (public and private) institutions will require you to do so to participate in their functions (e.g. attending public school, serving in the military, working in hospitals, etc...). In…

> You are not forced to take any vaccine Can we please just stop? “Take this or lose your job and pension” is not a choice.

and forcing people to work with walking bioweapons is not a choice either, so I don't see your point.

losing a job is not nearly as problematic as killing people because someone couldn't be arsed to take a couple jabs.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#503
post #144

I am thinking: if and when this is approved, we have to think about distribution. This drug is fantastically effective at preventing hospitalisation and death, if administered within three days of symptom onset. That gives quite a long time! But we still need to make it easy to take. Do pharmacies give it out? ER rooms? We don't want to wait until people are hospitalised; we are trying to avoid that. So when you test…

Who is the market for this? The assumption is that you give it ASAP and people want to take it. If people aren’t interested in vaccinations they may not want it either, and the vaccines are already very effective at preventing these issues.

And unfortunately the window for this closes before a skeptic will get desperate. Once people go on a vent they appear to become open minded to other treatment options.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#504

Earlier quoted context omitted.

Therefore how can you trust this drug? Follow the money! It’s just big science trying to propagate a pandemic to make more money! If this sounds insane, we’ll ok just reflecting the common anti vax sentiments I hear on this web site (ugh).

> the common anti vax sentiments I hear on this web site (ugh). Seeing this stuff so prevalent on HN really disappointed me.

Try to understand why this viewpoint exists. We are all logical people. The difference is in the trust of public media and government. Both sides of the argument are mostly right in what they believe given the information they are consuming. My suggestion - read sources from both sides before deciding that anyone slightly against Covid hysteria is misinformed and is an anti-vaxxer. Second suggestion, anti-vaxxer is a really misleading and extremely divisive term.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#505
post #476

Earlier quoted context omitted.

Data shows that being vaccinated divides your odds of dying and being hospitalized from covid by about 10. There's no evidence I'm aware of showing that the vaccines create additional risk anywhere close to outweighing that benefit.

Don’t mistake relative risk for absolute risk. Not everyone who is vaccinated gets Covid, but everyone vaccinated is at risk of vaccine side effects. If a 30 year old has a 0.08% chance of hospitalization, the risk drops to 0.008%. But they might stand a 1 in 5 chance of getting infected so now it’s 0.016% to 0.0016%. But if they get injected with a vaccine, the risk of a rare side effect might be 1 in 100,000 or 0.0…

I think 1 in 5 is very optimistic. Unless you intend to remove yourself from society, you are very likely to catch Sars-Cov-2 in the upcoming years. Probably more than once. It's endemic and easily transmittable.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#506
post #169

Earlier quoted context omitted.

I live in Kansas and have basically forgotten COVID is a thing. The people who wanted to get vaccinated like me have and those who haven’t, haven’t. Nobody asks about it and no businesses have any sort of mask requirements. Half of the people at the grocery store wear masks and the other half don’t. Everyone seems to be getting along. Next door in Kansas City Missouri I stopped at a gas station and an employee was sh…

I've always found it strange that some Americans focus on politeness above all. Of all the problems in your story, the employee shouting is the least 'wrong'. You've got a woman who won't wear a mask, yourself who sneaked in without a mask, and that's just in that moment of time, but somehow the employee who has to deal with that behavior all day every day is the bad person because they lost their cool. It's one of t…

I mean, I saw the “masks required in this county” sign, but I really needed to pee. I knew I was going to be driving through that county for about 20 more minutes, so I checked my car for a mask. I couldn’t find one as there’s no mask mandate in my area so I’ve stopped carrying a mask around. I then held my shirt up as best I could as a “mask” and made a bee line for the bathroom. If they’d had masks at the door I’d have been perfectly fine with putting one on.

I wasn’t making any judgment about the woman yelling at people, I’d be mad if I was being threatened with fines by the local government for having maskless people in my establishment too.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#507
post #169

Does anyone have a sense as to when US society will completely eliminate COVID measures? Is it just me or is there no clear exit criteria anymore? This will go on forever without exit criteria.

I live in Kansas and have basically forgotten COVID is a thing. The people who wanted to get vaccinated like me have and those who haven’t, haven’t. Nobody asks about it and no businesses have any sort of mask requirements. Half of the people at the grocery store wear masks and the other half don’t. Everyone seems to be getting along. Next door in Kansas City Missouri I stopped at a gas station and an employee was sh…

Lol it's nice that you can just send all the covid patients to the city to get treated and you guys can pretend covid doesn't exist

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#508
post #479
post #292

Earlier quoted context omitted.

Are you suggesting that every new molecule should be treated as if it were a prion?

Again, as someone who worked with toxicology, yeah. The default is every new molecule might be highly toxic and needs to be proven otherwise. It’s why we don’t look at a molecule and say “oh, that’s not a carcinogen! No need to test”. And the same reason we run hERG tests to make sure drugs don’t give you a fatal arrhythmia (a surprising number of drugs do this and some are still on the market).

So over what time period do you believe we should wait to release a drug to the public? 10 - 25 years after discovery?

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#509
post #292

Earlier quoted context omitted.

Are you suggesting that every new molecule should be treated as if it were a prion?

I'm suggesting that sometimes a very small amount of a substance can cause catastrophic effects a decade later. That's why we do testing before we release drugs. And Pfizer isn't the hero here, they never have been. https://corporatewatch.org/pfizer-six-scandals-to-remember/ This list doesn't even include Celebrex. 1986: Pfizer had to withdraw an artificial heart valve from the market after defects led to it being im…

There is nothing here that suggests that:

>very small amount of a substance can cause catastrophic effects a decade later.

Medication failure modes are either short-term acute and found in test quickly, like Trovan example; or where long-term ingestion causes problems.

All of your examples are one of those two.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#510
post #352

Earlier quoted context omitted.

Your children do not need it - perhaps you should evaluate whether they are in an 'at risk' category like the Nordics https://www.nature.com/articles/d41586-021-01897-w In the US, 340 children under 17 have died from Covid. Total. During the same period, 187 have died from the flu, and over 51,000 children have died from all causes: https://www.cdc.gov/nchs/nvss/vsrr/covid_weekly/index.htm#Se... Sweden halts Moderna:…

I though most of the point of vaxing children and other low-risk groups is to stop the spread, not for their own individual safety. Reducing the chance they'll infect grandma. And reducing the circulating pool of infections to prevent more virulent strains from developing. Have I got this wrong?

Yes you have it wrong. That goes against medical ethics. You can't give someone a treatment that is net detrimental to them in order to benefit others.
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