41–50 of 1001 posts
I think it’s hard to overstate what a big deal this is for science. This is a completely novel molecule that appears effective as an antiviral. This would a huge achievement for the field of drug design, and will hopefully lead to all kinds of great medicine.
> Pfizer’s phase 2/3 trial randomized non-hospitalized adult COVID-19 patients who were at high risk of progressing to severe illness to receive placebo or Paxlovid, a combination of the protease inhibitors Oh, a protease inhibitor you say? I was told those were horse dewormers by the media. This whole thing is bullshit. With this much money at stake we were never going to learn the truth.
Glad I waited instead of taking part in an experiment trial. There was an "easy" solution after all... I wonder what is the gotcha though, since it's a Pfizer study. Maybe something like selling a known molecule 10 times more expensive than before after rebranding it for the new usage?
Why is this drug less experimental than the vaccines?
Did anyone hear NPR's reporting on this? They said the early study was originally halted BECAUSE of it's positive effects at preventing hospitalization and death... very weird, I hope it is a typo or I'm understanding it wrong...
So as good as a vaccine basically?
Comparable individual outcome, worse societal outcome - you still spread it, so no reduction in overall cases, unlike a vaccine.
https://www.nature.com/articles/d41586-021-02689-y
https://www.businessinsider.com/delta-variant-made-herd-immu...
> Pfizer’s phase 2/3 trial randomized non-hospitalized adult COVID-19 patients who were at high risk of progressing to severe illness to receive placebo or Paxlovid, a combination of the protease inhibitors Oh, a protease inhibitor you say? I was told those were horse dewormers by the media. This whole thing is bullshit. With this much money at stake we were never going to learn the truth.
> There were six hospitalizations and no deaths among the 607 patients who received Paxlovid within five days of symptom onset, compared to 41 hospitalizations and 10 deaths in the placebo cohort. How does this work? You sign up for the program when you're sick and you might get meds that help you? That would really suck if a loved one was in the program and died because they happened to get the placebo.
If it does conclusively show effectiveness quite quickly, often they will cut the phase of the trial short and put everybody on the actual drug I think.
Good that we have something that actually works, bad that some assholes will use it as an excuse not to get vaxxed, completely missing the point (among others, trying to prevent something worse than Delta).