So as good as a vaccine basically?
Comparable individual outcome, worse societal outcome - you still spread it, so no reduction in overall cases, unlike a vaccine.
I thought the latest research was that the vaccinated can still spread COVID?
Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
31–40 of 1001 posts
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#32Three different headlines, three different efficacy percentages (89%, 90%, and now 85%), all of which originate from Pfizer's own studies. Color me dubious.
I also found the article a little hard to parse, but after a close read it seems that the 85% is the whole trial, and 89% is for people who got the drug within three days.
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#33The data sample is a bit low? 1200 people
The effect size was very large. The calculated p-value was https://www.pfizer.com/news/press-release/press-release-deta...
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#34Earlier quoted context omitted.
Comparable individual outcome, worse societal outcome - you still spread it, so no reduction in overall cases, unlike a vaccine.
I thought the latest research was that the vaccinated can still spread COVID?
Some might, but not all, which is still a reduction
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#35Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#36> There were six hospitalizations and no deaths among the 607 patients who received Paxlovid within five days of symptom onset, compared to 41 hospitalizations and 10 deaths in the placebo cohort. How does this work? You sign up for the program when you're sick and you might get meds that help you? That would really suck if a loved one was in the program and died because they happened to get the placebo.
The alternative is what we have right now, ‘scientists’ blathering about their assumptions with the constant disclaimer that nobody really knows for real. Real science does have a price.
> Real science does have a price.
I'm not following. Are you under the impression that the COVID-19 vaccine trials weren't similarly double blinded?
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#37I think it’s hard to overstate what a big deal this is for science. This is a completely novel molecule that appears effective as an antiviral. This would a huge achievement for the field of drug design, and will hopefully lead to all kinds of great medicine.
And it's here in _two_ years
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#38Did anyone hear NPR's reporting on this? They said the early study was originally halted BECAUSE of it's positive effects at preventing hospitalization and death... very weird, I hope it is a typo or I'm understanding it wrong...
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#39Three different headlines, three different efficacy percentages (89%, 90%, and now 85%), all of which originate from Pfizer's own studies. Color me dubious.
The differences in these percentages are all trivially small and explained in the article. 85% is the overall view; 89% is on the sub population treated within 3 days of symptom onset; and 90% appears to be an editorialized "almost" approximation from news agencies.
Fuck off with this fud.
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#40So as good as a vaccine basically?
Minus the preventative part.
Preventative of what?
Serious disease? - The same/similar (though studies have shown this declines within 6 months). Op is correct.
Catching/Transmission? - The current vaccines are systemic and not mucosal, so they don't stop it infecting the upper respiratory tract. - A recent study shows fully-vaccinated households can spread at similar rates to unvaccinated households [1]
[1] https://www.thelancet.com/journals/laninf/article/PIIS1473-3...