CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro
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Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro
#2I didn't read the article, but my very basic understanding of mRNA vaccines is that they cause your own cells to produce the spike protein so that your immune system can learn to attack it without actually having the virus present. Does this finding imply that the vaccine would also inhibit DNA damage repair? Or is it more like, in combination with the virus, the spike protein inhibits DNA repair?
Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro
#3I didn't read the article, but my very basic understanding of mRNA vaccines is that they cause your own cells to produce the spike protein so that your immune system can learn to attack it without actually having the virus present. Does this finding imply that the vaccine would also inhibit DNA damage repair? Or is it more like, in combination with the virus, the spike protein inhibits DNA repair?
It does imply that the vaccine would also inhibit DNA damage repair.
I think the key question is timescale. I suspect this would be a short-term side effect, with no real impact. If not -- if it's longitudinal -- it could be scary. I can't imagine how that would happen, though.
Virus would have the same effect, so this isn't an anti-vax argument.
Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro
#4I didn't read the article, but my very basic understanding of mRNA vaccines is that they cause your own cells to produce the spike protein so that your immune system can learn to attack it without actually having the virus present. Does this finding imply that the vaccine would also inhibit DNA damage repair? Or is it more like, in combination with the virus, the spike protein inhibits DNA repair?
It does imply that the vaccine would also inhibit DNA damage repair. I think the key question is timescale. I suspect this would be a short-term side effect, with no real impact. If not -- if it's longitudinal -- it could be scary. I can't imagine how that would happen, though. Virus would have the same effect, so this isn't an anti-vax argument.
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Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro
#5I didn't read the article, but my very basic understanding of mRNA vaccines is that they cause your own cells to produce the spike protein so that your immune system can learn to attack it without actually having the virus present. Does this finding imply that the vaccine would also inhibit DNA damage repair? Or is it more like, in combination with the virus, the spike protein inhibits DNA repair?
It does imply that the vaccine would also inhibit DNA damage repair. I think the key question is timescale. I suspect this would be a short-term side effect, with no real impact. If not -- if it's longitudinal -- it could be scary. I can't imagine how that would happen, though. Virus would have the same effect, so this isn't an anti-vax argument.
Half-life of mRNA is fairly small, as there is no shortage of enzymes that basically just break it down for recycling. The real problem would have to stem from DNA damage that occurred in the presence of the vaccine that did not either lead to cell death, or get repaired later.
Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro
#6I didn't read the article, but my very basic understanding of mRNA vaccines is that they cause your own cells to produce the spike protein so that your immune system can learn to attack it without actually having the virus present. Does this finding imply that the vaccine would also inhibit DNA damage repair? Or is it more like, in combination with the virus, the spike protein inhibits DNA repair?
It does imply that the vaccine would also inhibit DNA damage repair. I think the key question is timescale. I suspect this would be a short-term side effect, with no real impact. If not -- if it's longitudinal -- it could be scary. I can't imagine how that would happen, though. Virus would have the same effect, so this isn't an anti-vax argument.
Yeah, for context I'm fully vaccinated and not trying to create distrust of the mRNA vaccines. Just curious because that seems like a pretty bad thing. It makes sense that this would only happen while the spike proteins are actually present in your body. Thanks for the response!
Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro
#7I didn't read the article, but my very basic understanding of mRNA vaccines is that they cause your own cells to produce the spike protein so that your immune system can learn to attack it without actually having the virus present. Does this finding imply that the vaccine would also inhibit DNA damage repair? Or is it more like, in combination with the virus, the spike protein inhibits DNA repair?
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Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro
#8Earlier quoted context omitted.
It does imply that the vaccine would also inhibit DNA damage repair. I think the key question is timescale. I suspect this would be a short-term side effect, with no real impact. If not -- if it's longitudinal -- it could be scary. I can't imagine how that would happen, though. Virus would have the same effect, so this isn't an anti-vax argument.
Half-life of mRNA is fairly small, as there is no shortage of enzymes that basically just break it down for recycling. The real problem would have to stem from DNA damage that occurred in the presence of the vaccine that did not either lead to cell death, or get repaired later.
>The real problem would have to stem from DNA damage that occurred in the presence of the vaccine that did not either lead to cell death, or get repaired later.
Which is what it sounds like from the title and abstract.
Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro
#9"Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA..."
Can anyone translate?
Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro
#10"Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA..." Can anyone translate?
It hangs around the DNA and makes it hard for the DNA to do its own jobs. Like a really annoying and clueless co-worker.