Exome sequencing and analysis of 450k UK Biobank participants
1–10 of 65 posts
Re: Exome sequencing and analysis of 450k UK Biobank participants
#2From abstract: “… We discover several risk-increasing associations with traits related to liver disease, eye disease and cancer, among others, as well as novel risk-lowering associations for hypertension (SLC9A3R2), diabetes (MAP3K15, FAM234A) and asthma (SLC27A3)…“
Re: Exome sequencing and analysis of 450k UK Biobank participants
#3Does anyone remember the days when some geneticists were saying that 98% of DNA is "junk" DNA? When I heard it I knew it couldn't be true but it's probably going to take another 50 years to figure out how much really does get used.
I can't help but suspect that a lot of the genome is a part of the boot sequence that helps you go from one cell up to all the differentiated organs and tissues and systems.
Re: Exome sequencing and analysis of 450k UK Biobank participants
#4I think I missed the novel technique they applied.
Surely others try to match particular genes to diseases. Surely that’s one of the pillars of the entire field.
Re: Exome sequencing and analysis of 450k UK Biobank participants
#5Does anyone remember the days when some geneticists were saying that 98% of DNA is "junk" DNA? When I heard it I knew it couldn't be true but it's probably going to take another 50 years to figure out how much really does get used. I can't help but suspect that a lot of the genome is a part of the boot sequence that helps you go from one cell up to all the differentiated organs and tissues and systems.
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Re: Exome sequencing and analysis of 450k UK Biobank participants
#6Does anyone remember the days when some geneticists were saying that 98% of DNA is "junk" DNA? When I heard it I knew it couldn't be true but it's probably going to take another 50 years to figure out how much really does get used. I can't help but suspect that a lot of the genome is a part of the boot sequence that helps you go from one cell up to all the differentiated organs and tissues and systems.
Had the exact thought when I read the headline.
What arrogance. "I don't understand what these genes do. Must be junk"
Re: Exome sequencing and analysis of 450k UK Biobank participants
#7Does anyone remember the days when some geneticists were saying that 98% of DNA is "junk" DNA? When I heard it I knew it couldn't be true but it's probably going to take another 50 years to figure out how much really does get used. I can't help but suspect that a lot of the genome is a part of the boot sequence that helps you go from one cell up to all the differentiated organs and tissues and systems.
> I can't help but suspect that a lot of the genome is a part of the boot sequence that helps you go from one cell up to all the differentiated organs and tissues and systems.
Boot sequence. Amazing. I've always been interested in how the DNA transcription looks like a Turing machine with the RNAP being the head and the one DNA strand being the tape. Is there any research in that kind of computational analogy or is it just a coincidence?
Re: Exome sequencing and analysis of 450k UK Biobank participants
#8A reminder that these sorts of genome-wide studies are not particularly reliable due to the problem of multiple comparisons: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270946/
Re: Exome sequencing and analysis of 450k UK Biobank participants
#9awful lot of resources were spent to find very little of deep value. Genomics is just marginal gains for each huge new amount of capital invested.
Re: Exome sequencing and analysis of 450k UK Biobank participants
#10I think I missed the novel technique they applied. Surely others try to match particular genes to diseases. Surely that’s one of the pillars of the entire field.
The novelty lies in the size of the data set. ~450,000 exomes is a lot.