Schopenhauer used an equation with the answer of 42 to make a metaphysical point in “The World as Will and Idea.” I suspect this is the meaning Adams had in mind:
As time has only one dimension, counting is the only arithmetical operation, to which all others may be reduced; and yet counting is just intuition or perception a priori, to which there is no hesitation in appealing here, and through which alone everything else, every sum and every equation, is ultimately proved. We prove, for example, not that (7 + 9 × 8 - 2)/3 = 42; but we refer to the pure perception in time, counting thus makes each individual problem an axiom. Instead of the demonstrations that fill geometry, the whole content of arithmetic and algebra is thus simply a method of abbreviating counting. We mentioned above that our immediate perception of numbers in time extends only to about ten. Beyond this an abstract concept of the numbers, fixed by a word, must take the place of the perception; which does not therefore actually occur any longer, but is only indicated in a thoroughly definite manner. Yet even so, by the important assistance of the system of figures which enables us to represent all larger numbers by the same small ones, intuitive or perceptive evidence of every sum is made possible, even where we make such use of abstraction that not only the numbers, but indefinite quantities and whole operations are thought only in the abstract and indicated as so thought, as [sqrt](r^b) so that we do not perform them, but merely symbolise them.
I tried to add this on Wikipedia a while ago, but was overruled by an editor.
Source: https://gutenberg.org/cache/epub/38427/pg38427-images.html
More on Schopenhauer: https://www.locserendipity.com/TitleSearch.html?q=Schopen