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The Fugate family of Kentucky has had blue skin for centuries (2017)

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Re: The Fugate family of Kentucky has had blue skin for centuries (2017)

#71

Earlier quoted context omitted.

> inbreeding can serve a useful function Are there any examples of species doing this 'deliberately'?

Royal consanguinity marriages in old Europe. And many other places as well. Sibling marriages in Egypt and the Diadochi!

Ancient Ireland, too: https://www.newscientist.com/article/2246227-stone-age-rulin...

Re: The Fugate family of Kentucky has had blue skin for centuries (2017)

#72
post #68

Some oxiditation (1%) of Hb (Fe 2+) to metHb (Fe 3+) is normal, it gets reduced back by the enzyme Cytochrome b5 reductase. So far so good. But since metHb is dysfunctional and cannot bind oxygen and you need levels of at least 10% metHb to be visible as cyanosis: Why didn't they exhibit oxygen-deficit related symptoms? Or can your body compensate with other mechanism if it's congenital? At least when it is visibly i…

https://en.m.wikipedia.org/wiki/Methemoglobinemia

It would seem you are correct but these effects weren't touched on by the article.

Re: The Fugate family of Kentucky has had blue skin for centuries (2017)

#73

Earlier quoted context omitted.

> inbreeding can serve a useful function Are there any examples of species doing this 'deliberately'?

When they do it deliberately with cattle they call it line breeding.

Many show breed dog pedigrees have lots of ancestors, many of them the same dog.

Re: The Fugate family of Kentucky has had blue skin for centuries (2017)

#74
post #23

Maybe the old term for European aristocrat, blue blood, along with its inbreeding connotations, is more literal than history gives it credence. It's usually attributed to pale skin but perhaps methemoglobinemia was on display. https://www.historyextra.com/period/georgian/why-people-nobl...

If people had been quite literally blue, it would have been widely written about. You're talking about an era giving people nicknames based on their countenance and using any slight deformity for propaganda was quite common.

Re: The Fugate family of Kentucky has had blue skin for centuries (2017)

#75

This article touches on something that remains very true today: if you want to study genetic disorders you look at closely-related populations. If the condition you want to study is linked to a recessive gene, you want to find (or create) an isolated population with that gene. In animals/plants this is why inbreeding can serve a useful function. If you want to detect a recessive gene, but either don't have access to…

> inbreeding can serve a useful function Are there any examples of species doing this 'deliberately'?

Many, many species of plants are inbreeders. In the plant world, inbreeding and outbreeding seem to both be successful techniques with their own benefits and drawbacks.

Re: The Fugate family of Kentucky has had blue skin for centuries (2017)

#76

Earlier quoted context omitted.

Did you know stretching before a car trip prevents all but the worst car sickness? Both my chiropractor and my acupuncturist recommended it and I haven't suffered from car sickness since. There, I saved you the cost of the water pills. You don't need costly, potentially dangerous additive laced medicine if you're just looking for the placebo effect.

Yeah, but she feels sick in the car. Then we give her a pill. There is nothing dangerous in homeopathy, that’s the dilution effect. Another thread trending on the value of placebo: https://news.ycombinator.com/item?id=28887705

>There is nothing dangerous in homeopathy

Some of the pills are made using toxic fillers. It's not enough I'd panic over, you can get the placebo effect without ingesting anything shady/expensive.

Re: The Fugate family of Kentucky has had blue skin for centuries (2017)

#77
post #18

>Though today Benjy and most of the Fugate family descendants have lost their blue coloring, the tint still comes out in their skin when they are cold or flush with anger. I wish they had included at least one photograph of this.

If you Google the last name you’ll find some pictures

I think those are black and white with false colour

Re: The Fugate family of Kentucky has had blue skin for centuries (2017)

#78

This article touches on something that remains very true today: if you want to study genetic disorders you look at closely-related populations. If the condition you want to study is linked to a recessive gene, you want to find (or create) an isolated population with that gene. In animals/plants this is why inbreeding can serve a useful function. If you want to detect a recessive gene, but either don't have access to…

Look no further than European Royalty, for example Charles II of Spain's family tree ... er, family square, rather.

Re: The Fugate family of Kentucky has had blue skin for centuries (2017)

#79
post #74
post #23

Maybe the old term for European aristocrat, blue blood, along with its inbreeding connotations, is more literal than history gives it credence. It's usually attributed to pale skin but perhaps methemoglobinemia was on display. https://www.historyextra.com/period/georgian/why-people-nobl...

If people had been quite literally blue, it would have been widely written about. You're talking about an era giving people nicknames based on their countenance and using any slight deformity for propaganda was quite common.

True. Or maybe they covered it up with cosmetics, another stereotype of aristocrats?
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