Earlier quoted context omitted.
Why just read the book? Download Squeak - a bit far from the mainstream expectations, but it's free in the best sense. Or you can get VisualWorks Non-Commercial. (There's a very under-appreciated ASP-like web app framework in VisualWorks!)
I actually found Squeak to be a bit non-intuitive and lurid, but I have played with VisualWorks and Dolphin, to try & get a feel for Smalltalk, but I never really got my head round how things worked. Having a book handy means I have something to turn to the next time I give it a go.
Smalltalk is radically different in a fundamental way when it comes to your relationship to source code and the dev environment. All your source code changes are in something like a transaction log. When you're programming, you're just manipulating the meta-level more or less directly. When you do get it, there's a "whoa!" experience. Better yet, persevere and "get it" then go back to something like iPython. You'll get a real perspective shift!