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Antiviral compound blocks SARS-CoV-2 from entering cells

medicine.wustl.edu

11–20 of 193 posts

Re: Antiviral compound blocks SARS-CoV-2 from entering cells

#12

I'm starting to get pretty optimistic. There seem to be a bunch of antivirals with very different mechanisms of action - this one blocks entry of the virus to cells, Molnupiravir fucks up accurate replication of the virus (nucleoside analog), others are protease inhibitors, which are very effective against HIV. There's a caveat, most treatments that look promising don't pan out, but there are a lot in the pipeline an…

A limiting factor for the effectiveness of anti-virals for Covid is time. Maximum viral load happens often happens before any symptoms are present, and the most severe diseases occurs weeks after infection as a result of the bodies inflammatory response instead of the virus itself. This means that by the time you know that a patient will have severe Covid-19, it is likely too late for any treatment that is based on interfering with the virus itself.

Having said that, we have a good demographic understanding of who tends to get severe Covid-19, and a large testing capacity, so a cheap anti-viral treatment with few side effects could still be effectively deployed.

Re: Antiviral compound blocks SARS-CoV-2 from entering cells

#13

We already have a treatment that works fine. Get some ivermectin and chill.

> We already have a treatment that works fine. Get some ivermectin and chill. This isn’t a helpful comment. Please read the hacker news guidelines

It deserves consideration. Saved my but.

Re: Antiviral compound blocks SARS-CoV-2 from entering cells

#14

I'm starting to get pretty optimistic. There seem to be a bunch of antivirals with very different mechanisms of action - this one blocks entry of the virus to cells, Molnupiravir fucks up accurate replication of the virus (nucleoside analog), others are protease inhibitors, which are very effective against HIV. There's a caveat, most treatments that look promising don't pan out, but there are a lot in the pipeline an…

A limiting factor for the effectiveness of anti-virals for Covid is time. Maximum viral load happens often happens before any symptoms are present, and the most severe diseases occurs weeks after infection as a result of the bodies inflammatory response instead of the virus itself. This means that by the time you know that a patient will have severe Covid-19, it is likely too late for any treatment that is based on i…

There are some interesting nasal sprays that wipe out early viral load in the nose and throat that are available right now. ImmuneMist and XClear for example.

Re: Antiviral compound blocks SARS-CoV-2 from entering cells

#15
Interesting. So this drug, in addition to the novel compound being developed as a covid treatment by Pfizer, is a protease inhibitor, targeting TMPRSS specifically...just like a certain "horse dewormer" from recent memory[0]. Yeah, I know, "in vitro". Did you also know that the emergency vaccine authorization is explicitly contingent on there being "no adequate, approved, and available alternative to the product" for covid19[1]? Very interesting indeed.

0. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203399/#!po=12...

1. https://www.google.com/amp/s/theconversation.com/amp/what-ar... NOTE: it's getting hard to search for sources that mention this fact, and now that what little faith I've had in our institutions has effectively been destroyed, I suspect this is an emergent, collective, deliberate exclusion. Wouldn't want to give the proles any strange ideas about "conspiracy theories" and such.

Re: Antiviral compound blocks SARS-CoV-2 from entering cells

#16

Earlier quoted context omitted.

It is helpful. Ivermectin works so well Pfizer is copying it.

https://apnews.com/article/fact-checking-067310377629

Sorry, I don't care to read your government propaganda.

Re: Antiviral compound blocks SARS-CoV-2 from entering cells

#17

Earlier quoted context omitted.

A limiting factor for the effectiveness of anti-virals for Covid is time. Maximum viral load happens often happens before any symptoms are present, and the most severe diseases occurs weeks after infection as a result of the bodies inflammatory response instead of the virus itself. This means that by the time you know that a patient will have severe Covid-19, it is likely too late for any treatment that is based on i…

There are some interesting nasal sprays that wipe out early viral load in the nose and throat that are available right now. ImmuneMist and XClear for example.

ImmuneMist is already facing warnings of regulatory action for their false claims re: covid

https://www.ftc.gov/enforcement/warning-letters/warning-lett...

Re: Antiviral compound blocks SARS-CoV-2 from entering cells

#20

Earlier quoted context omitted.

It is helpful. Ivermectin works so well Pfizer is copying it.

https://apnews.com/article/fact-checking-067310377629

I find fact checkers quite interesting in the way they've been deployed over the last few years. As if one source is the "truth" and that settles things. Usually when you get to the end of "false" claims, you find some tidbits that make you wonder... such as:

"Several posts circulating online wrongly suggest that the pills are the same because ivermectin also acts like a protease inhibitor and keeps the virus from replicating. Ivermectin continues to be studied in relation to COVID-19, however, it has yet to be proven that it can treat COVID-19."

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