Bredesen has a book called The End of Alzheimer's, or something.
Unfortunately, the end of alzheimer is death :/
Reversal of cognitive decline: A novel therapeutic program
51–60 of 109 posts
Re: Reversal of cognitive decline: A novel therapeutic program
#52Earlier quoted context omitted.
If what you're telling me is that eating healthy, getting enough sleep and exercising can halt or reverse Alzheimer's it's not going to exactly shock me. The real fad is how amazingly stupid Americans are about their own health.
Was that zing really necessary? I'm trying to start a new diet plan over here, c'mon. There's just way too much good food in California.
I mentioned sleep, exercise, and a healthy diet and IMO they're all connected. Nowhere did I mention anything about weight. But since we're on the topic now, I disagree with BMI alone as the single indicator of health. Canada seems to be moving in that direction as well. I try to eat healthy myself, but restaurants borderline conspire against that because healthy dishes just don't sell as well as those California Cream Sauce Specials with limitless bread.
https://www.verywellhealth.com/canada-guidelines-redefine-ob...
Re: Reversal of cognitive decline: A novel therapeutic program
#53A thorough debunking of this protocol from The Lancet: https://sci-hub.se/downloads/2020-04-23/63/10.1016@S1474-442...
A few quotes:
> Despite the certainty inferred by the book’s subtitle, there is no published study that tests or proves the hypothesis that the Bredesen protocol can prevent and reverse cognitive decline.
> Readers are informed that participants with subjective cognitive impairment or mild cognitive impairment are included in the studies; however, both conditions can have causes unrelated to neurodegenerative processes. These studies are therefore not targeting a common underlying neuropathological process of Alzheimer’s disease, as the papers suggest.
> Readers might not be aware that the three case series evaluating the Bredesen protocol appear in journals considered by some to be predatory open access journals. [...] The journal Aging, where the first two articles were published, appears on the Beall’s list of potential, possible, or probable predatory open access journals [...]
> it is notable that the Bredesen protocol has been made commercially available; however, the authors do not disclose any conflicts of interest in their scientific reports.
Re: Reversal of cognitive decline: A novel therapeutic program
#54Earlier quoted context omitted.
American culture is staggeringly unhealthy. Denying this is impossible.
I think it is pretty easy to deny. The CDC breaks out obesity by demographics[1]. White adults have an obesity rate of ~29%. This is the same as other predominantly white/Anglo countries like Canada, Australia, and the United Kingdom[2]. Maybe 29% is staggeringly unhealthy, but it isn't American culture to be that overweight. Being overweight is fairly widespread and not unique to America. Probably it has more to do…
12th most obese nation in the world, I'd call that staggeringly unhealthy given our GDP:
https://obesity.procon.org/global-obesity-levels/
Also, 46th in life expectancy:
https://www.worldometers.info/demographics/life-expectancy/
Happy with those numbers? I'm not.
Re: Reversal of cognitive decline: A novel therapeutic program
#55Earlier quoted context omitted.
American culture is staggeringly unhealthy. Denying this is impossible.
I think it is pretty easy to deny. The CDC breaks out obesity by demographics[1]. White adults have an obesity rate of ~29%. This is the same as other predominantly white/Anglo countries like Canada, Australia, and the United Kingdom[2]. Maybe 29% is staggeringly unhealthy, but it isn't American culture to be that overweight. Being overweight is fairly widespread and not unique to America. Probably it has more to do…
> it isn't American culture to be that overweight
> hispanics and blacks are considerably more overweight than whites
Are these people not American?
Re: Reversal of cognitive decline: A novel therapeutic program
#56A thorough debunking of this protocol from The Lancet: https://sci-hub.se/downloads/2020-04-23/63/10.1016@S1474-442... A few quotes: > Despite the certainty inferred by the book’s subtitle, there is no published study that tests or proves the hypothesis that the Bredesen protocol can prevent and reverse cognitive decline. > Readers are informed that participants with subjective cognitive impairment or mild cognitive…
It feels like, in general, 10 data points are not enough to justify efficacy of a protocol.
One would also assume that simply exercising and eating properly on their own would have some measurable improvements. As the paper suggests, a larger case study would be in order, specifically with some combinations of the various measures in the protocol to determine individual and compound efficacy on a statistically relevant scale.
Re: Reversal of cognitive decline: A novel therapeutic program
#57Maybe I'm a cynic but it strains credulity that the miracle cure is also a laundry list of fad health trends from the the last decade. Gluten free, intermittent fasting, yoga, melatonin, probiotics, etc etc
Just wait for another paper claiming that the ketogenic diet is what really works.
Re: Reversal of cognitive decline: A novel therapeutic program
#58tldr personalized techniques: - Optimize diet: minimize simple CHO, minimize inflammation. - Patients given choice of several low glycemic, low inflammatory, low grain diets. - Enhance autophagy, ketogenesis - Fast 12 hr each night, including 3 hr prior to bedtime. - Reduce stress - Personalized—yoga or meditation or music, etc. - Optimize sleep - 8 hr sleep per night; melatonin 0.5mg po qhs; Trp 500mg po 3x/wk if aw…
Surprised not to see anything about sociality here. I imagine this is a large determinant of health and life span.
That's actually part of the "full" Bredesen protocol, I read it in his book, and you're right it is a big part of slowing and reversing the Alzheimer's decline.
Re: Reversal of cognitive decline: A novel therapeutic program
#59I've done a bit of research here. It's not snake oil. They did a trial, https://www.medrxiv.org/content/10.1101/2021.05.10.21256982v... , and it worked very well. It's being commercialized here: https://www.apollohealthco.com/ , and the guy has patents on everything.
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Re: Reversal of cognitive decline: A novel therapeutic program
#60in patient one they list fasting for extended periods of time and also "MCT effects" which refers to the administration of MCT oil. so in other words, this is a very convoluted way of doing what the ketogenic diet does. the fact that the ketogenic diet can reverse alzheimers in part or in full has been well established by Dr. Mary Newport. as well as it can be without support from the mainstream medical establishment -- they refuse to conduct proper studies on it out of sheer stupidity and stubbornness. i add "stupidity" because of how long theyve let the oversight go for.
ketosis does something to the immune system. in many people who have schizophrenia, touching the immune system sometimes has a direct impact on symptoms. there is a famous case of a young man whos symptoms went away after having his bone marrow removed as reported in the NYT. the articles goes on to connect many interesting cases and facts that orbit this idea. its official everyone, the NYT knows more about medicine than your doctor. another article, published by a practicing harvard psychiatrist in psychology today, presents three case studies of schizophrenics who go into remission upon entering ketosis. other people find fleeting relief after donating blood and thus diluting their blood. and blood dilution has been shown to directly impact tons of things at UCB especially things having to do with aging. its an indication of whats to come. our own bodies are producing inflammatory molecules that cause disease.
i have schizophrenia and i can say that these things are true and i have tested them.
whether AZ disease improvement upon entering ketosis is due to inflammation reduction or metabolic improvements due to using BHB rather than glucose in some cells, im not sure anyone knows.
i wonder if any doctor will stop to reflect on his own behaviour for a single second after he hears that the titan of AZ medications, which reduces plaques, does not fucking work? people like me have been saying for ages that AZ is caused by metabolic dysfunction and the plaques are a downstream artifact. well now the evidence against them and for me is so massive that they will have to write it in the sky. pure vindication.