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Reversal of cognitive decline: A novel therapeutic program

ncbi.nlm.nih.gov

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Re: Reversal of cognitive decline: A novel therapeutic program

#42
post #35

Earlier quoted context omitted.

Given that Americans work more than most other countries it’s a wonder how they get enough sleep or time to cook healthy.

México, Costa Rica, Korea, and Greece would like a word, on both working harder and eating better: https://www.weforum.org/agenda/2018/01/the-countries-where-p...

Mexico is more overweight than the US and tops your list of reported working hours.

Re: Reversal of cognitive decline: A novel therapeutic program

#43
post #41

I've done a bit of research here. It's not snake oil. They did a trial, https://www.medrxiv.org/content/10.1101/2021.05.10.21256982v... , and it worked very well. It's being commercialized here: https://www.apollohealthco.com/ , and the guy has patents on everything.

"They did a trial, https://www.medrxiv.org/content/10.1101/2021.05.10.21256982v..., and it worked very well."

Only 25 patients, not double-blind, no controls.

Re: Reversal of cognitive decline: A novel therapeutic program

#44
post #10

Maybe I'm a cynic but it strains credulity that the miracle cure is also a laundry list of fad health trends from the the last decade. Gluten free, intermittent fasting, yoga, melatonin, probiotics, etc etc

If what you're telling me is that eating healthy, getting enough sleep and exercising can halt or reverse Alzheimer's it's not going to exactly shock me. The real fad is how amazingly stupid Americans are about their own health.

I come from a family with Alzheimer's running through it like clockwork. I have some uncles who tried to live the right lifestyle.

It didn't help. If anything in my observations it made things worse. Though it's a meaningless sample size.

Re: Reversal of cognitive decline: A novel therapeutic program

#45

Earlier quoted context omitted.

American culture is staggeringly unhealthy. Denying this is impossible.

Not sure we're alone. Take the UK, for example. 2/3 are either overweight or obese. Better than the US? Sure. But what a weak victory that is.

I'm definitely biased by living in the southern hemisphere for almost half a decade. The places I've lived are visibly healthier than the US. People have less chronic health problems, take fewer sick days, etc.

Re: Reversal of cognitive decline: A novel therapeutic program

#46

tldr personalized techniques: - Optimize diet: minimize simple CHO, minimize inflammation. - Patients given choice of several low glycemic, low inflammatory, low grain diets. - Enhance autophagy, ketogenesis - Fast 12 hr each night, including 3 hr prior to bedtime. - Reduce stress - Personalized—yoga or meditation or music, etc. - Optimize sleep - 8 hr sleep per night; melatonin 0.5mg po qhs; Trp 500mg po 3x/wk if aw…

Can we get one supplement pill that merges all of those that need to be consumed? Kthx.

Eating real food is better than supplements. That can help a ton.

Re: Reversal of cognitive decline: A novel therapeutic program

#47

Maybe I'm a cynic but it strains credulity that the miracle cure is also a laundry list of fad health trends from the the last decade. Gluten free, intermittent fasting, yoga, melatonin, probiotics, etc etc

Gluten free is not snake oil.... if you have a Immune Celiac disease.

Melatonin helps with sleep disorders... for people with sleep disorders. There is a synthetic analog called Ramelteon.

Intermitent fasting has curious effects on insulin resistance, but not clinically relevant.

Probiotics reduce incidence and severity of traveler's diarrhea... for travelers. It has been comercially available for a while.

Like Ivermectin, which is not snake oil, but is also being sold for the same purposes as snake oil.

Re: Reversal of cognitive decline: A novel therapeutic program

#48

tldr personalized techniques: - Optimize diet: minimize simple CHO, minimize inflammation. - Patients given choice of several low glycemic, low inflammatory, low grain diets. - Enhance autophagy, ketogenesis - Fast 12 hr each night, including 3 hr prior to bedtime. - Reduce stress - Personalized—yoga or meditation or music, etc. - Optimize sleep - 8 hr sleep per night; melatonin 0.5mg po qhs; Trp 500mg po 3x/wk if aw…

Man, that sounds exactly like something you'd see one of the guests on the Tim Ferriss podcast talking about. What ever happened to ballroom dancing and bridge?

Speaking of which, I think if you want to be smart, don't do brain games. Do what the smartest people do: play an instrument and read challenging books.

I'm learning piano and it's a never ending brain game. You sit there for an hour trying to coax new neurons in various areas to grow.

Re: Reversal of cognitive decline: A novel therapeutic program

#49

Earlier quoted context omitted.

Ah yes, every single one of them. And none of the people in any other country.

American culture is staggeringly unhealthy. Denying this is impossible.

I think it is pretty easy to deny. The CDC breaks out obesity by demographics[1]. White adults have an obesity rate of ~29%. This is the same as other predominantly white/Anglo countries like Canada, Australia, and the United Kingdom[2].

Maybe 29% is staggeringly unhealthy, but it isn't American culture to be that overweight. Being overweight is fairly widespread and not unique to America.

Probably it has more to do with lifestyle changes (e.g. cars and working at computers) and diet changes (rise of processed and fast food). These things have disparate impact on racial groups, e.g. hispanics and blacks are considerably more overweight than whites. America having more hispanics and blacks than places like the UK, the US seems like it is more obese.

1 - https://ftp.cdc.gov/pub/Health_Statistics/NCHS/NHIS/SHS/2015...

2 - https://en.wikipedia.org/wiki/List_of_countries_by_obesity_r...

Re: Reversal of cognitive decline: A novel therapeutic program

#50

Earlier quoted context omitted.

Not sure we're alone. Take the UK, for example. 2/3 are either overweight or obese. Better than the US? Sure. But what a weak victory that is.

I'm definitely biased by living in the southern hemisphere for almost half a decade. The places I've lived are visibly healthier than the US. People have less chronic health problems, take fewer sick days, etc.

I imagine a lot of that depends on where in the US you go. I live in an area that is statistically similar to Europe. If your idea of the US is south and east, it will be considerably different.
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