A friend of mine had this idea but with opioids. He invented an opioid painkiller which was, IIRC, a positive allosteric modulator of the mu opioid receptor - I'm not an expert, but I believe the gist was that it enhanced your endogenous opioid system, and was therefore less prone to addiction.
He ended up finding a handful of papers scattered across the last decades where people had come to the same realisation, but nothing came of it. Now, it's very possible there was something wrong with the idea. He did synthesise the molecule and we both took it, but not for long enough to really assess - even in a Shulgin-like way - whether it was addictive. But he ended up suspecting that the reason nothing came of it is that a non-addictive drug is simply not profitable, and is dominated, in the game-theory sense, by addictive drugs which bring consistent and greater revenue streams.
Also, apropos of:
> reset the brain chemical state in such way that tolerance and addiction could not come up
You may want to look into ibogaine. It doesn't give you both the high and the 'resetting the brain' functions - it only does the latter - but it's a very interesting case in that it has a very successful track record in resetting addiction. Though research is hampered by the fact that its cardiotoxic properties have killed a bunch of people who didn't do proper ECGs etc to check for heart abnormalities before taking it.