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Evidence that overnight fasting could extend healthy lifespan [pdf]

media.nature.com

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Re: Evidence that overnight fasting could extend healthy lifespan [pdf]

#32
post #15

Earlier quoted context omitted.

I am not sure. I have a sister who used to do that and she wasn't overweight neither had any obvious eating disorder. Maybe it was because she was an athlete? I know other people with obvious weight problems that wake up in the middle of the night to eat and maybe for those it might be considered a disorder.

These people that want to live in their 80s or beyond boggle me. Who wants to stick around that long when you have so many contemporaneous failures of the body all crashing down on you? Better to just die catastrophically in your early to mid 70s and save yourself a drab decade or two.

Some people are healthier in their 80s than others in their 60s. The point is to be healthy for as long as possible.

Re: Evidence that overnight fasting could extend healthy lifespan [pdf]

#33
post #20

Even 16h-8h fast-feed periods are great for long-term health. Skipping breakfast with plain coffee for me have worked perfectly. Now I'll transition to a 8am-4pm feed period schedule, I've heard that it may improve sleep quality going with empty stomach to bed.

edit: commenter shared [0] which disproves my understanding. Intermittent fasting, when controlled for calorie (and protein) intake, had a healthy outcome than a 'normal' diet, but the sample size was only 14 women per group (IF and control).

I wish they would have stricter diets in the study. They control for smokers, but I wonder if participants in one group consume alcohol or deep-fried calories more than the other. Or even one group getting better sleep than the other group.

[0] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735806/

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My understanding is that Intermittent Fasting (IF) is built on shaky science b/c research doesn't control for calorie reduction (CR).

There are papers that suggest CR improves longevity. There are papers that say IF improves longevity, but I haven't found any research that says IF without CR improves longevity. IF studies allow subjects to eat unrestricted during food periods, but don't actually record how many calories are consumed. We don't know if the subjects (unintentionally) also CR during IF.

If IF helps people CR, then great, but I think its misleading to say that IF actually has direct health benefits.

Re: Evidence that overnight fasting could extend healthy lifespan [pdf]

#35

It doesn’t mention that autophagy in humans takes several days. Overnight fasting might help us but not for the reasons implied here.

I’ve never found good research on autophagy. Has anyone pinpointed when it starts?

Re: Evidence that overnight fasting could extend healthy lifespan [pdf]

#36
post #33
post #20

Even 16h-8h fast-feed periods are great for long-term health. Skipping breakfast with plain coffee for me have worked perfectly. Now I'll transition to a 8am-4pm feed period schedule, I've heard that it may improve sleep quality going with empty stomach to bed.

edit: commenter shared [0] which disproves my understanding. Intermittent fasting, when controlled for calorie (and protein) intake, had a healthy outcome than a 'normal' diet, but the sample size was only 14 women per group (IF and control). I wish they would have stricter diets in the study. They control for smokers, but I wonder if participants in one group consume alcohol or deep-fried calories more than the othe…

You're understanding is limited.

For a nice review check out this one [1]. Although most of 16:8 effects are minor, they build up over time.

[1]: https://examine.com/supplements/16-8-intermittent-fasting/

Re: Evidence that overnight fasting could extend healthy lifespan [pdf]

#37
post #23
post #20

Even 16h-8h fast-feed periods are great for long-term health. Skipping breakfast with plain coffee for me have worked perfectly. Now I'll transition to a 8am-4pm feed period schedule, I've heard that it may improve sleep quality going with empty stomach to bed.

Not trying to be snarky here but is 16pm supposed to be 6pm? 14 hour fast?

haha yeah. sorry about it. I meant 8:00 - 16:00 hrs.

Re: Evidence that overnight fasting could extend healthy lifespan [pdf]

#38

I've tried a few variations of fasting over the last ~3 years and here's what works best for me. Because I tend to snack, I have time-boxed my eating windows inline with a fasting schedule, so: - No breakfast, just black coffee - First eating window (~11am - 2pm) - Second eating window (~5pm - 8pm) - No eating after 8pm I've played with three eating windows and it also works quite well. I cheat on weekends, Fridays a…

> think about it as product market fit for your body + health

Willpower and default behaviors as a currency is how I think about it.

Re: Evidence that overnight fasting could extend healthy lifespan [pdf]

#39
post #36
post #33

Earlier quoted context omitted.

edit: commenter shared [0] which disproves my understanding. Intermittent fasting, when controlled for calorie (and protein) intake, had a healthy outcome than a 'normal' diet, but the sample size was only 14 women per group (IF and control). I wish they would have stricter diets in the study. They control for smokers, but I wonder if participants in one group consume alcohol or deep-fried calories more than the othe…

You're understanding is limited. For a nice review check out this one [1]. Although most of 16:8 effects are minor, they build up over time. [1]: https://examine.com/supplements/16-8-intermittent-fasting/

For a nice coverage of the effects, here:

https://examine.com/supplements/16-8-intermittent-fasting/re...

Re: Evidence that overnight fasting could extend healthy lifespan [pdf]

#40

Why do they even need fruit flies to do this kind of study? How difficult would it be to find human subjects for this?

Apart from the other points mentioned, I want to add that funding could be a potential issue for studies based on human subjects. More expensive and time consuming compared to studying flies.

The general flow of such research is to test various hypothesis on animals and then move forward to human studies only for the most promising ones.

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