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Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

merck.com

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Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#151

Post by roflc0ptic »

AndrewBissell wrote: post #92
DominikPeters wrote: post #58

I enjoyed this article explaining in more detail how the drug works, though much of it goes over my head: https://www.nature.com/articles/s41594-021-00657-8 Briefly, it causes the copying process of viral RNA to go wrong by increasing the number of G-to-A and C-to-U mutations. A potential worry is that such mutations will also increase in places where we don't want them, such as in host DNA, but apparently at least f…

Seems like a lot of added potential risk for anyone at low odds of being hospitalized for Covid. https://pesquisa.bvsalud.org/global-literature-on-novel-coro...

Curious why this is downvoted. Is this person wrong? It seems like an important detail if the drug is actually mutagenic in mammalian cells.

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#152

Post by dukeofdoom »

spear wrote: post #134
vixen99 wrote: post #118

Earlier quoted context omitted.

No, that is incorrect. The FDA Only renewed emergency use authorization for Pfizer; Approval was for BioNTech’s Comirnaty with additional safety studies required (until 2027). It's currently not available in the US.

It's the same thing -- Comirnaty is the brand name of the Pfizer/BioNTech COVID vaccine.

I'm not sure if that's the case legally. Is windows 11 same as windows 10, since both are a type of windows released by the same company. Let's say there's a security feature that works the same in both versions. But in windows 11 it was certified to work. I don't think you could sue effectively it failed in your installation of windows 10. MS could just say you should had no expectation for it to work because it wasn't certified to work at that time when you purchased your product. In fact the lack of certification necessarily implies that you used the feature at your own risk, and take full liability

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#153

Post by logicalmonster »

crooked-v wrote: post #53
logicalmonster wrote: post #40

Earlier quoted context omitted.

What are normal ICU levels and is this a goalpost that can ever be achieved? Long before Covid, it was well-known that hospital ICUs were designed to run fairly close to 100% capacity because it wasn't profitable to pay for staff that weren't truly needed at any given time. Is there any hospital that is going to pay for far more staff than they need and somehow manufacture many ICU beds out of nowhere? I feel like th…

> and is this a goalpost that can ever be achieved? It could absolutely be achieved. Literally the only thing keeping things from going back to more-or-less normal conditions right now is that there are many unvaccinated people getting extremely ill from COVID and filling up ICUs.

Again, what are normal ICU levels?

As far as I'm aware, ICU staffing is modified to achieve close to 100% capacity at all times with minimal spare beds, whether pre-Covid or post-Covid. If this is the case, then there's no scenario possible, regardless of what happens with Covid, where hospitals report anything but "few ICU beds are available".

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#154

Post by jeltz »

_3u10 wrote: post #30
jeltz wrote: post #22

Earlier quoted context omitted.

We, Sweden, lifted the mandate 2 days ago and after a clear trend of the small fourth wave not increasing.

Precisely. Also congrats on having sane politicians. Sweden has 10x the hospitalization rates of many countries that still have mandates, thus it is a political question, not a medical one.

What countries? Show me the data.

Edit: Deleting most of my post since Sweden does not track hospitalizations, only ICU admissions so I compared incorrectly. Here is the graph for ICU, judge for yoruselves if there are any with a 1/10 of Sweden's numbers.

https://ourworldindata.org/grapher/weekly-icu-admissions-cov...

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#156

Post by TechBro8615 »

felistoria wrote: post #20
mmastrac wrote: post #5

If I understand things correctly, this only helps _before_ hospitalization.

People need to be proactive and get tested if they feel a sickness coming on. It seems like there are a few good treatments if you catch it early. When you are hooked up to a ventilator it is too little too late.

Now we need a way to get these pills safely to someone’s door in less than 24 hours. If you call your doctor just when you’re developing Covid symptoms, he should be able to get a regimen of these pills delivered to you on the same day. Without that, they’re not only pointless but will seem ineffective.

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#157

Post by MisterBastahrd »

rflec028 wrote: post #140

Ivermectin is inexpensive to manufacture, is extremely safe, and is currently being used by many countries to both treat and prevent the spread of covid. Molnupiravir had concerns during its development of the drug having mutagagenic properties. Why not just use the inexpensive, safe, proven effective medication?

There aren't any first-world countries using ivermectin to treat or prevent the spread of COVID.

Because ivermectin is roundworm poison, not an antiviral. The countries were desperate to try ANYTHING, and it was the best they could get their hands on at the time. They were prompted to action because ivermectin affected COVID in lab experiments, not in actual cases, and the result of the use in those countries were that ICUs were inundated by people who were taking said poison.

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#158

Post by decebalus1 »

rflec028 wrote: post #140

Ivermectin is inexpensive to manufacture, is extremely safe, and is currently being used by many countries to both treat and prevent the spread of covid. Molnupiravir had concerns during its development of the drug having mutagagenic properties. Why not just use the inexpensive, safe, proven effective medication?

Disinformation kills. Please don't spread that here.

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#160

Post by admeyer »

Paragraph near the bottom of Reuters article on Molnupiravir states:

"Merck has said data shows molnupiravir is not capable of inducing genetic changes in human cells, but men enrolled in its trials had to abstain from heterosexual intercourse or agree to use contraception. Women of child-bearing age in the study could be pregnant and also had to use birth control."

Link to said Reuters article: https://www.reuters.com/business/healthcare-pharmaceuticals/...

What do you suppose would happen?

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