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Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

merck.com

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Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#121

Post by [deleted] »

crooked-v wrote: post #113
hunterb123 wrote: post #94

Earlier quoted context omitted.

Maybe they couldn't get a doctor to prescribe them the human pill because of all the politicization so they took the "horse paste" version. You seem to have first hand knowledge of all these people's situations, are you following people to the livestock supply stores or talking out of your ass from stories you read on Reddit? Most people that I know have that have took Ivermectin were taking the human pill. Only on t…

It's been well-documented in the news, including people being hospitalized after overdosing on the stuff: https://www.mississippifreepress.org/15002/person-hospitaliz... https://www.usatoday.com/story/news/health/2021/08/25/iverme... https://www.fda.gov/consumers/consumer-updates/why-you-shoul...

[deleted]

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#122

Post by SideburnsOfDoom »

carbocation wrote: post #37

I think it's disappointing that this thread has devolved into a political discussion that is hardly related to the topic. The scientific/medical achievement here seems significant. As an MD, the difference between calling in a script for a pill and arranging for outpatient infusion therapies is vast.

> devolved into a political discussion

Welcome to the "intelligentsia" debating anti-Covid measures. On the topic, you usually see worse than this.

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#123

Post by andybak »

carbocation wrote: post #37

I think it's disappointing that this thread has devolved into a political discussion that is hardly related to the topic. The scientific/medical achievement here seems significant. As an MD, the difference between calling in a script for a pill and arranging for outpatient infusion therapies is vast.

Be wary of commenting on the tone of a thread. Skimming it 39 minutes later and it seems a very reasonable, varied thread. Wait for voting to do it's thing.

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#124

Post by ceejayoz »

dukeofdoom wrote: post #96
whateveracct wrote: post #81

Earlier quoted context omitted.

Pfizer isn't emergency use

Last time I kept up with this, it was some purposeful legal loophole. The drug that got approved, is not yet available. I have a friend who is a nurse that's getting fired because she will not take the vaccine. She has patients that had adverse effects from the vaccine. I totally understand why she would not take it.

> Last time I kept up with this, it was some purposeful legal loophole. The drug that got approved, is not yet available.

No, that was a maliciously stupid misreading of the FDA's statement.

https://www.reuters.com/article/factcheck-fda-pfizer/fact-ch...

> The FDA state that Comirnaty has the same formulation as the EUA-approved (Emergency Use Authorization) Pfizer vaccine and is interchangeable (here). Their website says: “Providers can use doses distributed under EUA to administer the vaccination series as if the doses were the licensed vaccine. For purposes of administration, doses distributed under the EUA are interchangeable with the licensed dose.” (here).

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#125

Post by ceejayoz »

vixen99 wrote: post #118
whateveracct wrote: post #81

Earlier quoted context omitted.

Pfizer isn't emergency use

No, that is incorrect. The FDA Only renewed emergency use authorization for Pfizer; Approval was for BioNTech’s Comirnaty with additional safety studies required (until 2027). It's currently not available in the US.

False.

https://www.reuters.com/article/factcheck-fda-pfizer/fact-ch...

> The FDA state that Comirnaty has the same formulation as the EUA-approved (Emergency Use Authorization) Pfizer vaccine and is interchangeable (here). Their website says: “Providers can use doses distributed under EUA to administer the vaccination series as if the doses were the licensed vaccine. For purposes of administration, doses distributed under the EUA are interchangeable with the licensed dose.” (here).

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#126

Post by vsef »

WaitWaitWha wrote: post #70
WaitWaitWha wrote: post #56

This is not my field. But if there is a pill that can reduce death by 50% from the virus, I would like to know more about it. > Bright's concerns that similar drugs in its class have mutagenic properties As a layperson, this instantly raises a red flag in my mind. Should I be concerned? Why, or why not? More importantly, where can I find research that elucidates this for me?

>That's the effect of NHC and of molnupiravir. What about the bad side? Well, auxh nucleosides can also be taken up by many other enzymes, including those that handle our own nucleic acids, so some of them are mutagenic. Indeed, that's how NHC was first characterized, as a mutagen in bacteria. They also tend to be cytotoxic, via a number of mechanisms, and nucleoside drug candidates are notorious for wiping out in hu…

There are quite a few nucleoside analogues that have been used for HIV treatment: AZT, Zerit, FTC, Videx, Abacavir, 3TC, Hivid. There may be others I'm missing.

Of these, only Abacavir and FTC (as part of Truvada) are still used, the others have fallen out of use or are no longer even manufactured due to their bad side effect profiles and propensity for severe adverse reactions. 'Nuke-sparing' regimen planning specifically would combine other classes of drugs to avoid this class due to side effect issues.

I think it's great to have this new treatment option but this class of medications is well known for its side effects. Avoiding vaccines as 'unproven' and then going for this in particular I would consider eye rollingly wrong headed.

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#127

Post by programmarchy »

rory wrote: post #86
lsternlicht wrote: post #43

Phase 3 trial was stopped on a positive interim analysis by DSMB and in consultation with FDA Interim analysis was performed on approximately half of the total enrolled patients (775 of the 1550). Trial included many delta and other variant patients ————— Efficacy • ~50% reduction in hospitalization (14.1% PBO vs 7.3% drug) • 100% reduction in deaths (8 PBO vs 0 drug) ————— Safety • fewer adverse reactions in the dru…

Is 40% adverse reaction to a placebo typical? Really makes me wonder how many "side effects" are in our heads..

Couldn’t the adverse events in the placebo arm actually be caused by Covid?

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#128

Post by mhb »

dbcooper wrote: post #105
photochemsyn wrote: post #55

Some interesting points on the nature of our pharmaceutical patent system... (and while the cohort in this study does seem a bit small, the conclusions appear to be fairly valid): > "Molnupiravir was invented at Drug Innovations at Emory (DRIVE), LLC, a not-for-profit biotechnology company wholly owned by Emory University, and is being developed by Merck & Co., Inc. in collaboration with Ridgeback Biotherapeutics." >…

Why do people here always want to reduce the equity and income of pharma and biotech scientists?

It must be because they have extensively modeled the optimal societal benefit of reducing the financial incentive to these entities.

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#129

Post by gfodor »

crooked-v wrote: post #113
hunterb123 wrote: post #94

Earlier quoted context omitted.

Maybe they couldn't get a doctor to prescribe them the human pill because of all the politicization so they took the "horse paste" version. You seem to have first hand knowledge of all these people's situations, are you following people to the livestock supply stores or talking out of your ass from stories you read on Reddit? Most people that I know have that have took Ivermectin were taking the human pill. Only on t…

It's been well-documented in the news, including people being hospitalized after overdosing on the stuff: https://www.mississippifreepress.org/15002/person-hospitaliz... https://www.usatoday.com/story/news/health/2021/08/25/iverme... https://www.fda.gov/consumers/consumer-updates/why-you-shoul...

Since you cited the hilarious poison control story, you might enjoy this analysis: https://astralcodexten.substack.com/p/too-good-to-check-a-pl...

Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent

#130

Post by xxpor »

rossdavidh wrote: post #100
kazinator wrote: post #45

Earlier quoted context omitted.

> exerts its antiviral action through introduction of copying errors during viral RNA replication How does this target only viral RNA, not the body's own? Copying errors don't sound like something you want in your own RNA. "However, there are inherent risks in this approach. NHC can be metabolized by the host cell to the 20-deoxyribonucleoside form by the ribonucleotide reductase and then incorporated into the host c…

I believe the reason the trial was in unvaccinated people, was so that it would have a big enough signal to detect quickly. If you did the same trial with vaccinated subjects, it might still be making a 50% reduction in hospitalization, but it would take a lot longer to detect that. I don't think the idea is to only give it to the unvaccinated.

I'd love to talk to someone who refused to get vaccinated but gave their informed consent to participate in this trial.

Kind of boosts my personal theory is that a lot of vaccine hesitancy is driven by the fact that it's an injection and if it were a pill instead people would be more willing to take it.

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