If I understand things correctly, this only helps _before_ hospitalization.
My understanding as well. By the time people are hospitalized, the disease isn't necessarily still prolific in their body; the post-infection damage kills them.
Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent
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Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent
#22Earlier quoted context omitted.
If it halves hospitalizations, it'll have a pretty drastic effect on overwhelmed ICUs but there's probably still a ways to go before ICU levels return to normal and we can skip mandates.
Norway, Sweden, and the UK no longer have mandates, it's a political question not a medical question.
We, Sweden, lifted the mandate 2 days ago and after a clear trend of the small fourth wave not increasing.
Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent
#23Earlier quoted context omitted.
If it halves hospitalizations, it'll have a pretty drastic effect on overwhelmed ICUs but there's probably still a ways to go before ICU levels return to normal and we can skip mandates.
If we’re worried about hospital capacity why are we firing healthcare workers?
We have vaccine mandates because infected healthcare workers spreading COVID reduce capacity even more. We haven't actually fired many workers, because the vast majority just get the vaccine (mostly before the mandates).
Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent
#24Earlier quoted context omitted.
If it halves hospitalizations, it'll have a pretty drastic effect on overwhelmed ICUs but there's probably still a ways to go before ICU levels return to normal and we can skip mandates.
If we’re worried about hospital capacity why are we firing healthcare workers?
I'm no policy or health care expert, but maybe because front-line and hospital workers are exposed to extremely large viral loads which seem to be related to the severity of the disease, and taking one HCW off the front-lines and adding them to the sick in the ICUs is worse than one less HCW and the same ICU level?
This seems like you are trying to start a flamewar about vaccine mandates, BTW.
Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent
#25This is phenomenal news - I'm also curious how the various tribalist memes evolve. Will the vaccine maximalists who ridiculed "horse paste" when the data was still weak in part because a pill-based regime would undermine the message that vaccines ought to be mandatory embrace this much needed second tier therapeutic? Will the anti-vaxxers who will inevitably see this as the goal of a big pharma conspiracy covering up the efficacy of their drug of choice demonize this treatment despite the fact it conflicts with their fears of a vaccine conspiracy and will undermine the justification of mandates? Get the popcorn.
edit: Maybe this should be marketed as Ivermectin 2? I bet that would get more unvaccinated people to take it.
Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent
#26If I understand things correctly, this only helps _before_ hospitalization.
Right. Other wise "reduces risk of hospitalization" wouldn't make sense...
Well, yeah -- tautologically, it only helps reduce risk of hospitalization before hospitalization. But it could still be a useful therapy post-hospitalization -- I don't know.
Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent
#27A potential bottleneck in the deployment of this is that only Heimdall is able to wield the Molnupiravir.
Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent
#28https://www.nytimes.com/2021/10/01/us/merck-antiviral-pill-c... The NYTimes article sort of came off as suggesting this is a cheaper, easier to administer alternative to monoclonal antibodies. So I wonder what the overall effect will be on the number of deaths going forward. It’s definitely phenomenal science though, and hopefully we can use this to keep people out of the hospital!
The mechanisms of action are different. I expect clinicians would want to use both, at least for high risk cases.
Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent
#29Earlier quoted context omitted.
No, that seems to be false? > At the interim analysis, molnupiravir reduced the risk of hospitalization or death by approximately 50%
Studies indicate ivermectin works given before hospitalization, doesn't work during hospitalization.
No. Studies on ivermectin are mixed, and it seems like the ones that showed positive effects had falsified data[1]. Additionally, this trial does not demonstrate that Molnupiravir is ineffective after hospitalization.
[1]: https://www.theguardian.com/science/2021/jul/16/huge-study-s...
Re: Antiviral Molnupiravir Reduces Risk of Hospitalization/Death by ~50 Percent
#30Earlier quoted context omitted.
Norway, Sweden, and the UK no longer have mandates, it's a political question not a medical question.
We, Sweden, lifted the mandate 2 days ago and after a clear trend of the small fourth wave not increasing.
Precisely. Also congrats on having sane politicians. Sweden has 10x the hospitalization rates of many countries that still have mandates, thus it is a political question, not a medical one.