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Little Exercise, Big Effects: Reversing Aging

jneurosci.org

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Re: Little Exercise, Big Effects: Reversing Aging

#21

Post by Cushman »

Alex3917 wrote: post #14
danielharan wrote: post #11

Earlier quoted context omitted.

Cannabis as a treatment for Alzheimer's would be rather ironic, given its current reputation.

Actually the cool thing about it is that not only does it prevent neuroinflammation, but it also promotes neurogenesis. There was a recent study that tracked IQs before and after using cannabis, and what they found was that those who took up smoking cannabis actually gained almost six IQ points. (For less than 3.5 grams per week.) http://en.wikipedia.org/wiki/Long-term_effects_of_cannabis#M...

Huh— it's more than I would have guessed, but thinking about it, I buy it. Anecdotally, an eighth a week is about the point where you can see it starts to slow people down.

I can't help but feel like it's got as much to do with the fact of smoking every day as with the raw amount... I guess there aren't that many people out there who'll smoke an eighth in a day and then take a week off, though, so maybe it'd be hard to pin down.

Re: Little Exercise, Big Effects: Reversing Aging

#22

Post by Mz »

Alex3917 wrote: post #15
Cushman wrote: post #12

Earlier quoted context omitted.

If it's a receptor thing, it wouldn't only apply to phytocannibanoids, right? I'm given to understand there are a number of synthetic cannabinoid receptor agonists with much higher affinity and/or selectivity than the phytocannabinoids. Are you aware of any research into the potential differences? I suppose it wouldn't make much difference, since as you say it only takes a tiny amount of cannabis despite THC being on…

"Are you aware of any research into the potential differences?" Not off the top of my head, but here are some links to 'databases' of hundreds or thousands of research articles on cannabinoids: http://www.letfreedomgrow.com/cmu/GrannysList-Jan2011.pdf http://www.cannabis-med.org/studies/study.php http://www.cannabis-med.org/index.php?lng=en In general though I think cannabis is a good example of why plant-based medic…

Totally off topic, but do you happen to know anything about capsaicin?

I began eating hot peppers a few months ago and it had a dramatic impact on my condition. CF is rooted in a defect in a cell channel, the CFTR, which handles trafficking of certain molecules into and out of the cell. Capsaicin, the active ingredient in hot peppers, forces a different channel open at lower than normal temps. I asked around and got a snippet or two suggesting some indirect relationship between the types of things the two channels process but nothing conclusive. Capsaicin has worked effectively as a biohack for me, especially when combined with walking (and a zillion other things I was already doing for my condition). Yet I have turned up little in the way of solid information as to why/how.

Re: Little Exercise, Big Effects: Reversing Aging

#23

Post by m0nastic »

My girlfriend just told me about a study that also seemed to show that exercise can be useful in treatment of schizophrenia (by promoting hippocampal development).

This appears to be the study (she read it in Psychology Today, which didn't reference it by name):

http://www.ncbi.nlm.nih.gov/pubmed/20124113

Re: Little Exercise, Big Effects: Reversing Aging

#24

Post by cpeterso »

asifjamil wrote: post #17

Interesting article. I remember reading somewhere the opposite hypothesis. The argument went like this: more exercise --> faster metabolism --> faster consumption of your body utilities --> lower life expectancy

Well, the study is called "[A] Little Exercise, Big Effects", not "More Exercise, More Results."

Re: Little Exercise, Big Effects: Reversing Aging

#26

Post by Alex3917 »

Mz wrote: post #22
Alex3917 wrote: post #15

Earlier quoted context omitted.

"Are you aware of any research into the potential differences?" Not off the top of my head, but here are some links to 'databases' of hundreds or thousands of research articles on cannabinoids: http://www.letfreedomgrow.com/cmu/GrannysList-Jan2011.pdf http://www.cannabis-med.org/studies/study.php http://www.cannabis-med.org/index.php?lng=en In general though I think cannabis is a good example of why plant-based medic…

Totally off topic, but do you happen to know anything about capsaicin? I began eating hot peppers a few months ago and it had a dramatic impact on my condition. CF is rooted in a defect in a cell channel, the CFTR, which handles trafficking of certain molecules into and out of the cell. Capsaicin, the active ingredient in hot peppers, forces a different channel open at lower than normal temps. I asked around and got…

I don't know a ton about it, but I know there is a food company that just launched a line of capsaicin beverages:

http://www.prometheussprings.com

If you like spicy things they are actually really good. It's kind of like a combination between drinking a Snapple and getting maced in the face by the cops.

Re: Little Exercise, Big Effects: Reversing Aging

#27

Post by jamesbritt »

ristretto wrote: post #4

The HN title gives the impression that they reversed aging. They only reversed changes in memory performance in old mice that are infected with E.coli. It would be interesting to know how they assessed memory performance - are they using spatial memory tests?

The HN title gives the impression that they reversed aging.

The initial title was too long for HN, so I truncated it. I apologize if it ended up misleading.

Re: Little Exercise, Big Effects: Reversing Aging

#28

Post by Mz »

Alex3917 wrote: post #26
Mz wrote: post #22

Earlier quoted context omitted.

Totally off topic, but do you happen to know anything about capsaicin? I began eating hot peppers a few months ago and it had a dramatic impact on my condition. CF is rooted in a defect in a cell channel, the CFTR, which handles trafficking of certain molecules into and out of the cell. Capsaicin, the active ingredient in hot peppers, forces a different channel open at lower than normal temps. I asked around and got…

I don't know a ton about it, but I know there is a food company that just launched a line of capsaicin beverages: http://www.prometheussprings.com If you like spicy things they are actually really good. It's kind of like a combination between drinking a Snapple and getting maced in the face by the cops.

Sort of funny in a way. I do drink a fair variety of fruit juices these days as well. And their website might be a source of interesting info.

Thanks.

Re: Little Exercise, Big Effects: Reversing Aging

#30

Post by kragen »

Alex3917 wrote: post #5

For what it's worth, cannabis also prevents neuroinflammation, even in extremely low doses: http://www.youtube.com/watch?v=2uVXs6CY2ps http://www.freedomtoexhale.com/clinical.pdf The endocannabinoid system seems to be the main mechanism our bodies use to naturally regulate inflammation. My understanding is that there is a growing belief among cannabinoid researchers that our cannabinoid receptors can get blocked as w…

> cannabinoids ... are anti-angiogenic, meaning they cut off the blood flow to the tumors.

Hmm, like thalidomide? They must not be very anti-angiogenic, or heavy pot smokers would give birth to babies missing limbs.

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