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Elizabeth Holmes urged employees to hide Theranos’ lab equipment from inspectors

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Re: Elizabeth Holmes urged employees to hide Theranos’ lab equipment from inspectors

#101

The crazy thing about Theranos is that so many people with experience in microfluidics (developed mainly for DNA sequencing although there are other uses) knew that their claims were impossible, technologically speaking. Working with such small volumes to obtain quantitive estimates of blood chemistry is so implausible, as you are introducing uncontrollable variability - micro-evaporation, even tissue localization is…

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Re: Elizabeth Holmes urged employees to hide Theranos’ lab equipment from inspectors

#102

Earlier quoted context omitted.

There are companies (at least one anyway) that make rapid testing panels that include COVID, plus a dozen plus other respiratory diseases, in a single test that is profitable at $200 and costs $20 in consumables. I heard that they disabled all the other tests so they could get approved as a COVID test sooner, or something like that. The problem is you can't ask for such a test as a patient, hospital billing departmen…

If the regulators get out of the way it would be great to make these available direct to consumer with an app companion, and the consumer can share the results with their physician.

Millions and millions, millions of tests per day could be available today, except that the FDA is sitting on the applications, many of which I’ve looked at. And the applications are stellar. There’s absolutely no reason for an inexpensive three- or four-dollar test to be being outright rejected by the FDA right now or just sitting in a queue for many months. It’s no longer a normal time at the FDA, they’re being held up there for unknown reasons.

Coronavirus (COVID-19): Press Conference with Michael Mina, 02/24/21

https://www.hsph.harvard.edu/news/features/coronavirus-covid...

Re: Elizabeth Holmes urged employees to hide Theranos’ lab equipment from inspectors

#103
The famous picture of her taking reporters into the machine shop is one example.

“Touring the machine shop” is an old trick when you want to waste time and not show anyone anything. Technically naive people don’t realize that modern machines each have a computer attached to them, and there is little proprietary in most shops.

Re: Elizabeth Holmes urged employees to hide Theranos’ lab equipment from inspectors

#104

The crazy thing about Theranos is that so many people with experience in microfluidics (developed mainly for DNA sequencing although there are other uses) knew that their claims were impossible, technologically speaking. Working with such small volumes to obtain quantitive estimates of blood chemistry is so implausible, as you are introducing uncontrollable variability - micro-evaporation, even tissue localization is…

> What just amazed me is how gullible all the investors were, and how they didn't do due diligence, hire outside experts, or anything. Weird. When you're sat on stage next to Bill Clinton people assume someone somewhere has done some due diligence already. Turns out there are a lot more jobs out there to do with marketing, hype, and event planning than there are doing fact checking.

What is Bill Clinton but a hype man, though? The board of Theranos was filled with names evocative of gravitas to baby boomers, but whose input on anything would be worthless.

Re: Elizabeth Holmes urged employees to hide Theranos’ lab equipment from inspectors

#105

The modern wisdom, "fake it till you make it", requires you to make it, otherwise you'll pay for lying to us.

I'm curious, does this case get so much publicity because it touches upon all the tropes of Silicon Valley? 'Fake it till you make it', 'move fast and break things', 'disrupt the markets', etc. IMHO, this business model is fine when the only things at risk are venture capital and you're trying to sell more widgets, but when it comes to life and safety - bad news.

All of those things, but also I think a factor we all underestimate is Elizabeth herself has this super creepy presence in nearly every photo and video where she makes an appearance -- something just seems "off", in an almost uncanny valley sort of way, and confirmation that something is in fact "off" in the form of an actual scandal, I think, might satisfy some deep emotion that drove views to the original news stories that showed her picture. Those pictures stick with you, even sans-scandal.

Can't wait to see who they cast in the inevitable Netflix series.

Re: Elizabeth Holmes urged employees to hide Theranos’ lab equipment from inspectors

#106

The crazy thing about Theranos is that so many people with experience in microfluidics (developed mainly for DNA sequencing although there are other uses) knew that their claims were impossible, technologically speaking. Working with such small volumes to obtain quantitive estimates of blood chemistry is so implausible, as you are introducing uncontrollable variability - micro-evaporation, even tissue localization is…

You mean like most people currently know that most of the crypto-claims are bs but hype it up anyway?

You don't invest in something that's changing the world, you're investing in something that gains value, changing the world is just the narrative to get the sucker downstream to jump on board

EDIT: to add something less controversial, i can recommend the book "the key man" of a similar bluff in the impact investing space

Re: Elizabeth Holmes urged employees to hide Theranos’ lab equipment from inspectors

#107
post #54

The crazy thing about Theranos is that so many people with experience in microfluidics (developed mainly for DNA sequencing although there are other uses) knew that their claims were impossible, technologically speaking. Working with such small volumes to obtain quantitive estimates of blood chemistry is so implausible, as you are introducing uncontrollable variability - micro-evaporation, even tissue localization is…

> how they didn't do due diligence "due diligence" processes are in practice a lot less stringent or rigorous than an outsider would expect them to be given the amount of money involved. Companies get bought based on glorified sales pitches and nobody looks too hard at what they're buying is the unfortunate truth of the matter. Investors are no better.

We worked with a med-tech company, as a subcontract. That company kept getting funding, investors kept pumping money in. Despite the company now being to old the justify being a startup, they had never been profitable.

We happend to know one of the newer investors and asked who did technical due dilligence, because from what we could tell the primary product was just a bunch of outdated open source software glued together and general build on 15 year old tech. We got a very angry call from the CEO telling us “to mind our own fucking business”. We don’t work for them anymore.

Re: Elizabeth Holmes urged employees to hide Theranos’ lab equipment from inspectors

#108

The crazy thing about Theranos is that so many people with experience in microfluidics (developed mainly for DNA sequencing although there are other uses) knew that their claims were impossible, technologically speaking. Working with such small volumes to obtain quantitive estimates of blood chemistry is so implausible, as you are introducing uncontrollable variability - micro-evaporation, even tissue localization is…

A dead giveaway for throwaway board seats: Nobel Prize winners, generals, politicians. Another: “professional board members” who sit on multiple boards but have never had senior executive roles involving profit and loss.

These people may be accomplished in their own right, but they know little about business. They are there for lunch, the fat fee, and to pose.

And when a big company has a NUMBER of these types, i.e. two or more, they have an authoritarian/secrecy problem.

Re: Elizabeth Holmes urged employees to hide Theranos’ lab equipment from inspectors

#109
post #83

Earlier quoted context omitted.

Can you provide any examples of a high-profile company, ultimately shown to be dishonest, where the early investors were able to “cash out” before this dishonesty became known?

Uber Explanation, since this is being downvoted. Uber might not have lied about their business, but it surely looks like investors never cared about the businesses viability and rather only cared about being able to turn a profit on their investment (which was the point being made by the gp). To this day, it is still not clear if Uber’s business model is viable. Also not to mention the original CEO/founder’s reputati…

Agreed. EBITDA in general is hot garbage, but that is egregious.

Re: Elizabeth Holmes urged employees to hide Theranos’ lab equipment from inspectors

#110
Beyond all the fraud, lying, and deceit, the real shame is the lost opportunity and the associated colossal mismanagement. Theranos was able to marshal about a billion dollars with an overarching goal of democratizing access to health data. They basically accomplished nothing. Generating such a concentration of resources for this goal was a notable accomplishment. The subsequent arrogant (and stupid) inability to discern "hard" from "impossible" and adjust their approach to maintain some chance of success to the overarching goal was a grotesque and massive failure.
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