>I wholeheartedly believe I could have played top 500 region online matches and gotten away with it
Unless you were already near the top, climbing rapidly up rankings (in a 3rd party ladder) is going to be very suspicious. Draw enough attention and I think it's not unlikely someone would find evidence (not evidence of how your system works, but video proof that shows cheating).
And if the humanization is so good that it can literally never be detected... then better players with more knowledge and game sense will consistently still win. You'd need to be a good player in the first place - which is actually where the danger lies. A pro player with an undetectable cheat they can toggle on momentarily, even just once a series at a crucial moment, could make all the difference.
I've given up relying on technical anti-cheat solutions for online games. If it is apparent someone is cheating by watching them play then that's enough for me (and I've seen some _very_ subtle cheaters get banned from leagues for the most minor of slip-ups.) The only way to be totally sure are if the game is played on a LAN and the equipment is sufficiently controlled.