Honestly, switching to a more natural layout like Dvorak is probably one of the best things you can do for wrist pain. I don't think there have been any studies on it yet, but anecdotally it's great. Many people report likewise.
It's not easy to switch but imo it's well worth the time to optimize one of the primary interfaces with which you will interact with the world for decades to come.
It's so bizarre to me that we are all stuck on a horribly unoptimized interface and we continue to teach our children how to use it, when much-better performing alternatives are easily available.