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Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

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Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#71

Post by martincmartin »

ed wrote: post #4

Here’s the paper https://www.aging-us.com/article/203485 > The study population comprised adults (5 males, 1 female) with significant memory decline aged 64 years and older > The protocol consisted of 60 daily sessions at 5 sessions per week within a three-month period. Each session included breathing 100% oxygen by mask at 2ATA for 90 min with 5 min air breaks every 20 min. > At baseline, patients attained a mean gl…

(102.4 ± 7.3 to 109.5 ± 5.8, p=0.004)

106 is well within a standard deviation of both of those. In fact, 109.5 is only one standard deviation away from the first, and the reverse is almost true. How do they get p = 0.004?

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#72

Post by gfodor »

lthornberry wrote: post #70

HBOT is a widely used 'alternative' treatment for other neurological conditions. It's controversial, in part because there are very good reasons that it can cause neurological damage. This study is NOT a reason for anyone to run out and get HBOT. Even if the effect is real (and I don't think the study has enough info to draw than conclusion), you would need much larger trials to balance benefits and side effects.

If HBOT is potentially beneficial, the proper response to a study is to tell people to raise it to their doctor to see if it makes sense for them.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#73

Post by markenqualitaet »

wheaties wrote: post #62
ed wrote: post #4

Here’s the paper https://www.aging-us.com/article/203485 > The study population comprised adults (5 males, 1 female) with significant memory decline aged 64 years and older > The protocol consisted of 60 daily sessions at 5 sessions per week within a three-month period. Each session included breathing 100% oxygen by mask at 2ATA for 90 min with 5 min air breaks every 20 min. > At baseline, patients attained a mean gl…

6!? They used an N=6 to make such a bold claim? If I had ever thought about that as a sample size for any scientific research my professor would have run me off campus.

With 6 subjects, it feels a bit silly to even turn on the math. 5% is about two legs of a participant. I think humans can process those low numbers instantly, intuitively; we can do it by pattern recognition, without the need for abstraction. The statistics of a dinner party. I think even some animals could do some "math" on 6 food.

Should be called "collected case studies" or something.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#74

Post by hh3k0 »

LinuxBender wrote: post #53
nradov wrote: post #51

Earlier quoted context omitted.

5 psi chamber pressure won't get you to 2.4 ATA of inspired oxygen. Be really careful with building a chamber yourself. A fire inside a pressure chamber is a horrible way to die. Asphyxiation and explosive decompression are also risks.

Correct, 2.4 specifically is 35.27 PSI. I was just suggesting I can start with a small amount of pressure to test it myself. Avoiding explosions is rather simple. The air in the chamber can be normal levels of O2, which just means I need a proper mask that does not leak the O2 or the air I exhale. I already have O2 sensors. I can just tell it to alarm at 25% O2. Watching the videos on making the chamber is actually g…

"Avoiding explosions is rather simple." – now, why does that read like famous last words?

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#75

Post by anjel »

GordonS wrote: post #24
Cthulhu_ wrote: post #16

Earlier quoted context omitted.

Citation needed; I know research into psychedelics is difficult due to restrictions, but anecdotal evidence is not enough to start recommending it without listing the necessary caveats. I mean "Ivermectin has been shown to significantly help with Covid" has the same weight to it, and I'd never recommend anyone take horse dewormer. Maybe if they had worms and it was the only thing available.

> research into psychedelics is difficult due to restrictions, but anecdotal evidence is not enough to start recommending it Eh? Lions Mane doesn't have any psychedelic or psychoactive effects.

Lions mane isn't psychedelic, but it's noticably psychoactive. Similar to caffeine in effect, intensity and duration without the jitters or sleep disturbance.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#76

Post by tcoff91 »

robbiep wrote: post #40
zzt123 wrote: post #29

Thoughts that popped up: 1. Isn’t hyperbaric therapy used by athletes to reduce inflammation? 2. Isn’t the failure of the amyloid hypothesis leading to researchers considering whether inflammation is the progenitor of Alzheimer’s? So if hyperbaric therapy does work… could that be a sign in favor of the inflammation hypothesis? Although, the authors suggest the results are due to improved oxygenation rather than any a…

The amyloid hypothesis is not dead - just like the tau hypothesis is not dead. The $1m question is what role do the proteins play and at what stage and to what degree

There are so many plausible Alzheimer’s theories that it makes me wonder: are multiple of them right? Is Alzheimer’s really many different diseases that present the same way?

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#77

Post by orangepurple »

gfodor wrote: post #72
lthornberry wrote: post #70

HBOT is a widely used 'alternative' treatment for other neurological conditions. It's controversial, in part because there are very good reasons that it can cause neurological damage. This study is NOT a reason for anyone to run out and get HBOT. Even if the effect is real (and I don't think the study has enough info to draw than conclusion), you would need much larger trials to balance benefits and side effects.

If HBOT is potentially beneficial, the proper response to a study is to tell people to raise it to their doctor to see if it makes sense for them.

Doctors are stressed, overworked, and only keep up on cutting edge research at yearly conferences and sometimes through the grapevine. Your typical doctor won't know anything about HBOT.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#78

Post by LinuxBender »

hh3k0 wrote: post #74
LinuxBender wrote: post #53

Earlier quoted context omitted.

Correct, 2.4 specifically is 35.27 PSI. I was just suggesting I can start with a small amount of pressure to test it myself. Avoiding explosions is rather simple. The air in the chamber can be normal levels of O2, which just means I need a proper mask that does not leak the O2 or the air I exhale. I already have O2 sensors. I can just tell it to alarm at 25% O2. Watching the videos on making the chamber is actually g…

"Avoiding explosions is rather simple." – now, why does that read like famous last words?

I promise I will capture it on video so you can laugh at me.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#79

Post by GordonS »

anjel wrote: post #75
GordonS wrote: post #24

Earlier quoted context omitted.

> research into psychedelics is difficult due to restrictions, but anecdotal evidence is not enough to start recommending it Eh? Lions Mane doesn't have any psychedelic or psychoactive effects.

Lions mane isn't psychedelic, but it's noticably psychoactive. Similar to caffeine in effect, intensity and duration without the jitters or sleep disturbance.

I've never heard of it having any stimulating effects; indeed, I've heard it can be helpful with sleep. Are you able to point to supporting information?

In my last comment I was speaking from experience too - I tried taking it for 3 months, and never noticed any effects whatsoever.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#80

Post by [deleted] »

orangepurple wrote: post #77
gfodor wrote: post #72

Earlier quoted context omitted.

If HBOT is potentially beneficial, the proper response to a study is to tell people to raise it to their doctor to see if it makes sense for them.

Doctors are stressed, overworked, and only keep up on cutting edge research at yearly conferences and sometimes through the grapevine. Your typical doctor won't know anything about HBOT.

[deleted]
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