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Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

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Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#51

Post by nradov »

LinuxBender wrote: post #50
harryleeming wrote: post #7

I'm using 2.4ATA 90min back to back sessions to treat my covid induced brain fog, with great results. It's the first time in a year I can think clearly. Anyone with long covid should seriously look into this as a treatment, it has some solid science behind it and is very safe, albeit expensive. At this point I've tried 14 different drugs, not a single thing has moved the needle except this. More info here on it for l…

I found some instructional videos on how to make the chamber, looks very easy. It's only 5 PSI of pressure and an O2 mask. I already know how to make O2. This might be a fun project. On further reading, these aren't legal to have in the home in some countries due to fire codes.

5 psi chamber pressure won't get you to 2.4 ATA of inspired oxygen. Be really careful with building a chamber yourself. A fire inside a pressure chamber is a horrible way to die. Asphyxiation and explosive decompression are also risks.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#52

Post by smolder »

Cthulhu_ wrote: post #16
35mm wrote: post #10

Anyone interested in this should also take a look at Lions Mane Mushrooms. They have been shown to significantly help with cognitive decline.

Citation needed; I know research into psychedelics is difficult due to restrictions, but anecdotal evidence is not enough to start recommending it without listing the necessary caveats. I mean "Ivermectin has been shown to significantly help with Covid" has the same weight to it, and I'd never recommend anyone take horse dewormer. Maybe if they had worms and it was the only thing available.

Horse dewormer is just one way Ivermectin is used, just like ketamine is a horse tranquilizer, but has other uses. Not advocating people take it or buy horse dewormer to get it, but you shouldn't call it that generally.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#53

Post by LinuxBender »

nradov wrote: post #51
LinuxBender wrote: post #50

Earlier quoted context omitted.

I found some instructional videos on how to make the chamber, looks very easy. It's only 5 PSI of pressure and an O2 mask. I already know how to make O2. This might be a fun project. On further reading, these aren't legal to have in the home in some countries due to fire codes.

5 psi chamber pressure won't get you to 2.4 ATA of inspired oxygen. Be really careful with building a chamber yourself. A fire inside a pressure chamber is a horrible way to die. Asphyxiation and explosive decompression are also risks.

Correct, 2.4 specifically is 35.27 PSI. I was just suggesting I can start with a small amount of pressure to test it myself. Avoiding explosions is rather simple. The air in the chamber can be normal levels of O2, which just means I need a proper mask that does not leak the O2 or the air I exhale. I already have O2 sensors. I can just tell it to alarm at 25% O2. Watching the videos on making the chamber is actually giving me a bit of a chuckle. I see people building these really complex steel chambers with hundreds of bolts as if they were expecting 50k PSI. I bet I could do this with plexiglass or even plastic. I can even add several pressure relief valves that open just above the threshold.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#54

Post by nradov »

easytiger wrote: post #21
robbedpeter wrote: post #17

Earlier quoted context omitted.

60 sessions, 90 minutes, 100% oxygen via mask with breaks every 20 minutes, over 3 months, 5 per week. Seems like this is a great thing, hopefully it pans out over larger populations of patients.

100% oxygen under high pressure is dangerous

There is a fire risk, but competent chamber operators will make sure that patients don't bring in any ignition sources or highly flammable objects.

There will also be some pulmonary oxygen toxicity effects. Based on the protocol described those will be limited and resolve quickly in most patients.

The oxygen exposure is too limited to cause any significant risk of neurological effects, like a seizure.

So I don't know whether this treatment is actually effective but it's not particularly dangerous.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#55

Post by Arbalest »

lambdaba wrote: post #46
Arbalest wrote: post #41

Earlier quoted context omitted.

What is this impaired glucose metabolism you refer to? What are it's causes?

Insulin resistance

Oh so basically somewhere between normal and type 2 diabeties

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#56

Post by nradov »

zzt123 wrote: post #29

Thoughts that popped up: 1. Isn’t hyperbaric therapy used by athletes to reduce inflammation? 2. Isn’t the failure of the amyloid hypothesis leading to researchers considering whether inflammation is the progenitor of Alzheimer’s? So if hyperbaric therapy does work… could that be a sign in favor of the inflammation hypothesis? Although, the authors suggest the results are due to improved oxygenation rather than any a…

There's a huge difference between the acute, localized inflammation from a sports injury versus the chronic, systemic inflammation associated with some metabolic diseases. Acute inflammation is actually a useful part of the healing process so we don't necessarily want to reduce it unless it's causing other problems.

Hyperbaric oxygen therapy appears to be somewhat effective for accelerating healing certain soft tissue injuries. So athletes have used it. But it's not clear whether that therapy is any more effective than other recovery modalities. Research has been limited.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#57

Post by nradov »

Arbalest wrote: post #55
lambdaba wrote: post #46

Earlier quoted context omitted.

Insulin resistance

Oh so basically somewhere between normal and type 2 diabeties

There are a lot of people who appear normal and even have a hemoglobin A1c level in the normal range but are still insulin resistant. Usually the best way to check is with a glucose tolerance test.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#58

Post by nradov »

sgeisler wrote: post #18

If this turns out to be true I wonder if it'd be practical (given the financial resources) to have pressure sealed rooms that you spend a lot of time in at home (e.g. your office). These could be precisely controlled (O2, CO2 levels, pressure, …) and possibly both increase current and future performance. The main problem seems the time needed to exit because an abrupt loss of pressure would be hazardous. But if you h…

Breathing oxygen at a partial pressure over about 0.5 atm causes progressive pulmonary oxygen toxicity (loss of vital capacity). Brief exposures like the treatment protocol described in this paper are fine but it's not something you want to do all day every day. Saturation divers who live under pressure for days are careful to control chamber oxygen pressure below that limit.

Nitrogen is regular air is an anaesthetic. It literally makes you stupid, and the effects increase with pressure. If you want to be smarter you need to replace the nitrogen with helium. The high pitched voices are going to make Zoom meetings hilarious.

So generally working under pressure is totally impractical.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#59

Post by OneEyedRobot »

ezekiel68 wrote: post #26
vncecartersknee wrote: post #20

Earlier quoted context omitted.

Ivermectin is an FDA approved drug and is regularly prescribed to humans. Sure, it probably doesn't do anything for covid but it's not just 'horse dewormer'.

You can remove the "probably". The manufacturer of Ivermectin states there is no scientific evidence [0] supporting the use of the drug for COVID-19. So much for the notion some espouse that "Big Pharma" pushes their drugs on us without fail. [0] https://www.merck.com/news/merck-statement-on-ivermectin-use...

Just to throw this out there. https://c19ivermectin.com/

It's a pity that the whole issue has become politicized, but that's modern times for you. That's why ivermectin is called 'horse dewormer' rather than simply a medicine for parasite infections with a number of human applications. It's a term like 'XXXX denier' which is used to tie a political adversary to concentration camps by playing on our disgust or fears.

Does it do anything for COVID? Dunno. Should it be a discussable matter without internet censorship and crazy people twitterstorms? Maybe. Am I sick of being propagandized by everyone? Yes.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#60

Post by spywaregorilla »

smolder wrote: post #52
Cthulhu_ wrote: post #16

Earlier quoted context omitted.

Citation needed; I know research into psychedelics is difficult due to restrictions, but anecdotal evidence is not enough to start recommending it without listing the necessary caveats. I mean "Ivermectin has been shown to significantly help with Covid" has the same weight to it, and I'd never recommend anyone take horse dewormer. Maybe if they had worms and it was the only thing available.

Horse dewormer is just one way Ivermectin is used, just like ketamine is a horse tranquilizer, but has other uses. Not advocating people take it or buy horse dewormer to get it, but you shouldn't call it that generally.

Calling it horse dewormer is probably somewhat salient if you're taking the horse sized portion, rather than the human sized portion, however.
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