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Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

technology.org

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Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#41

Post by Arbalest »

lambdaba wrote: post #35
zzt123 wrote: post #29

Thoughts that popped up: 1. Isn’t hyperbaric therapy used by athletes to reduce inflammation? 2. Isn’t the failure of the amyloid hypothesis leading to researchers considering whether inflammation is the progenitor of Alzheimer’s? So if hyperbaric therapy does work… could that be a sign in favor of the inflammation hypothesis? Although, the authors suggest the results are due to improved oxygenation rather than any a…

I think the etiology is best summed up as "energy deficiency", basically the mitochondria aren't able to provide enough energy. Nutritional repletion, ketogenic diets, ketone supplementation (specifically ketone esters) and everything else that improves energy supply / circumvents issues (impaired glucose metabolism being #1) will help.

What is this impaired glucose metabolism you refer to? What are it's causes?

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#42

Post by xattt »

harryleeming wrote: post #7

I'm using 2.4ATA 90min back to back sessions to treat my covid induced brain fog, with great results. It's the first time in a year I can think clearly. Anyone with long covid should seriously look into this as a treatment, it has some solid science behind it and is very safe, albeit expensive. At this point I've tried 14 different drugs, not a single thing has moved the needle except this. More info here on it for l…

What’s the long-term plan? Is there a point where you wean off or is this a rest-of-your-life thing?

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#43

Post by nxpnsv »

tinco wrote: post #11
nxpnsv wrote: post #6

Earlier quoted context omitted.

The popular paper completely fails to to state sample size or selection. It seems 10+10 mice also were studied. Maybe a little early to call it a breakthrough...

What do you mean? The sample size was 6, and they were selected on having the same symptoms. There is more information on the statistical analysis in the paper, but the conclusion is that it was significant. If this is a significant treatment of Alzheimer's then that's a breakthrough to me, what bar would you set?

I mean that the article on technology.org doesn't state the sample size, but still claims this has proven the effectiveness of the treatment. You would have a hard time getting a treatment cleared for public use with those numbers. If you treat 6 people and they seem to go in some direction, then you have to put that into context by having some sort of control or else it is not possible to evaluate the degree to which the improvement was in patient selection or pure chance. I think that OPs article overstates the significance at this point and should have highlighted that further studies are necessary.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#44

Post by elithrar »

_Microft wrote: post #9
kragen wrote: post #8

Earlier quoted context omitted.

What's "ATA"? The scammy-looking commercial page you linked doesn't mention it.

I found something. "ata" seems to mean "atmosphere absolute" and describes the total pressure: "The ata unit is used in place of atm to indicate the total pressure of the system, compared to a vacuum. For example, underwater pressure of 3 ata would mean that this pressure includes 1 atm of air pressure and thus 2 atm due to the water." , from https://en.wikipedia.org/wiki/Standard_atmosphere_(unit)#Pre...

Correct. More specifically, you breathe a denser oxygen mix (2 atmospheres of density).

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#46

Post by lambdaba »

Arbalest wrote: post #41
lambdaba wrote: post #35

Earlier quoted context omitted.

I think the etiology is best summed up as "energy deficiency", basically the mitochondria aren't able to provide enough energy. Nutritional repletion, ketogenic diets, ketone supplementation (specifically ketone esters) and everything else that improves energy supply / circumvents issues (impaired glucose metabolism being #1) will help.

What is this impaired glucose metabolism you refer to? What are it's causes?

Insulin resistance

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#48

Post by wkyle »

sgeisler wrote: post #18

If this turns out to be true I wonder if it'd be practical (given the financial resources) to have pressure sealed rooms that you spend a lot of time in at home (e.g. your office). These could be precisely controlled (O2, CO2 levels, pressure, …) and possibly both increase current and future performance. The main problem seems the time needed to exit because an abrupt loss of pressure would be hazardous. But if you h…

On a more feasible scale, a similar idea could be better air filtration/ventilation. Better ventilation in homes or offices to decrease CO2 levels could be an easier way to achieve a similar effect.

https://www.nytimes.com/2019/05/06/health/conference-room-ai...

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#49

Post by parliowl »

ed wrote: post #4

Here’s the paper https://www.aging-us.com/article/203485 > The study population comprised adults (5 males, 1 female) with significant memory decline aged 64 years and older > The protocol consisted of 60 daily sessions at 5 sessions per week within a three-month period. Each session included breathing 100% oxygen by mask at 2ATA for 90 min with 5 min air breaks every 20 min. > At baseline, patients attained a mean gl…

I skimmed the article for the pertinent table. Three observations:

1. There is no control group. Since people get better with cognitive tests with practice, we don’t know whether these improvements were due to the treatment or just the normal practice effect. (Though if I were a betting person, my money is on the latter.)

2. Cognitive tests are not noiseless. The same person may vary by a few points between repeated tests. The modest improvements on most tests found here might not be above this noise floor.

3. The most impressive result (memory) is almost certainly regression to the mean. That is, the group did unusually poorly on this task in the first session by chance, then they performed more typically in the second, which looks falsely like a big improvement.

Basically, I think this paper provides no meaningful evidence of cognitive improvement in humans. I can’t speak about the mice stuff, that might be fine.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#50

Post by LinuxBender »

harryleeming wrote: post #7

I'm using 2.4ATA 90min back to back sessions to treat my covid induced brain fog, with great results. It's the first time in a year I can think clearly. Anyone with long covid should seriously look into this as a treatment, it has some solid science behind it and is very safe, albeit expensive. At this point I've tried 14 different drugs, not a single thing has moved the needle except this. More info here on it for l…

I found some instructional videos on how to make the chamber, looks very easy. It's only 5 PSI of pressure and an O2 mask. I already know how to make O2. This might be a fun project. On further reading, these aren't legal to have in the home in some countries due to fire codes.
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